Results 121 to 130 of about 45,032 (221)

A Tale of Two Cell Lines: Characterization of Differential Efficacy of Small Molecule Drugs Cediranib and NU‐7441 on Primary Versus Metastatic Colorectal Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Colorectal cancer is recognized as one of the leading causes of cancer death amongst both sexes in the U.S. Despite rigorous screening, those diagnosed with colon cancer often face poor prognosis, and approximately 70% of affected patients will develop metastatic relapse. The investigation of colon carcinoma cell lines' genetic variability and
Josephine D. Tsang, Cai M. Roberts
wiley   +1 more source

FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response. [PDF]

Cancer Res
Banerjee M, Zaytseva YY, Reusch EM, Napier DL, Hasani S, Rychahou P, Izumi T, Cheek DA, Li J, Flight RM, Moseley HNB, Weiss HL, McCulloch W, Evers BM, Gao T.   +14 more
europepmc   +1 more source

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić, Marko Skelin, Yun Wah Lam, Almir Fajkić, Bruna Perkov‐Stipičin, Rossana Roncato, Ivan Krečak, Marko Lucijanić   +7 more
wiley   +1 more source

Distinct safety profiles of liposomal and conventional irinotecan: insights from clinical experience and real-world data. [PDF]

Front Pharmacol
Shan H, Huang S, Du Q, Wang M.
europepmc   +1 more source

Quantum‐Capacitance Biosensing Enables Real‐Time Monitoring of Naxitamab for Therapeutic Response Stratification in Neuroblastoma

Small Science, Volume 6, Issue 8, August 2026.
Quantum‐capacitance biosensing enables real‐time monitoring of naxitamab in patient samples via laser‐fabricated electrodes and single‐point calibration. The proposed platform provides rapid and sensitive quantification, with the potential to enable therapeutic drug monitoring and patient stratification according to circulating naxitamab levels, while ...
Andy Bruno, Ruslán Alvarez‐Diduk, Paula Lara, Gabriel Maroli, Cristina Larrosa, Sandra López‐Miralles, Jaume Mora, Carlos J. Rodríguez‐Hernández, Arben Merkoçi   +8 more
wiley   +1 more source

Elucidating the Solvent-Dependent Solvation and Structural Stability of Irinotecan: A Molecular Simulation Study. [PDF]

Chemphyschem
Bitabo MM, Mlowe S, Shadrack DM, Paluch AS, Paul L.   +4 more
europepmc   +1 more source

First‐Time Demonstration of a Two‐Step Mechanism for Azo Dye Removal by Bacillus proteolyticus Using Molecular Docking and FT‐IR

Water Environment Research, Volume 98, Issue 8, August 2026.
Bacillus proteolyticus OA7, isolated from textile wastewater, efficiently removed Acid Red 88 (69.74%) and Acid Blue 193 (41.01%) through substrate‐dependent mechanisms. Acid Red 88 removal involved both biosorption and biodegradation, whereas Acid Blue 193 was mainly biosorbed. FT‐IR revealed functional group changes associated with EPS, proteins, and
Safiye Elif Korcan, Nevin Çankaya, Serap Yalçın Azarkan, Kübra Çitekçi, Şah İsmail Çivi, Gülderen Uysal Akkuş   +5 more
wiley   +1 more source

Efficacy of an XPO1 inhibitor in combination with irinotecan in a preclinical colorectal cancer model. [PDF]

Front Oncol
Lentz RW, Dominguez ATA, Balmaceda NB, Arcaroli JJ, Bagby SM, Binns CA, Smoots SG, Jackson MM, Macbeth M, Holmstoen T, Banerjee T, Whitty PA, Yi SS, Lieu CH, Messersmith WA, Pitts TM.   +15 more
europepmc   +1 more source

Safety and Efficacy of FOLFIRI-3 (Split-Dose Irinotecan) for Unresectable Colorectal Cancer: A Stratified Analysis Based on <i>UGT1A1</i> Gene Polymorphisms. [PDF]

Cancers (Basel)
Ohira G, Miyauchi H, Tochigi T, Maruyama T, Okada K, Hirata A, Ikeda Y, Hayano K, Maruyama M, Ishige T, Matsushita K, Shuto K.   +11 more
europepmc   +1 more source

Redefining the Role of Chemotherapy and Targeted Cytotoxic Delivery in Lung Neuroendocrine Tumors

Thoracic Cancer, Volume 17, Issue 16, August 2026.
Perioperative chemotherapy utility remains uncertain and lacks universal standardization. Platinum/etoposide shows suboptimal efficacy in lung NET (neuroendocrine tumors); oral alkylators (temozolomide) alone or in combination (e.g., with capecitabine), and cabozantinib offer promising disease control.
Alice Laffi, Giuseppe Lamberti, Anna La Salvia   +2 more
wiley   +1 more source