Results 121 to 130 of about 61,613 (221)

Upfront Comprehensive Genomic Profiling in Advanced Biliary Tract Cancer: Real‐World Implementation and Clinical Outcomes

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Biliary Tract Cancers (BTCs) are difficult‐to‐treat malignancies with limited therapeutic options and dismal prognosis. Upfront comprehensive genomic profiling (CGP) is recommended for advanced BTC to identify actionable alterations, but its real‐world implementation remains underexplored. Methods In 2019, we implemented upfront CGP
Saskia Hussung, Mia Roth, Dilara Akhoundova, Clelia Pistoni, Judith Konrat, Franca Lisy, Tabea Ibach, Tomas Brezina, Markus Rechsteiner, Daniela Lenggenhager, Martin Zoche, Holger Moch, Achim Weber, Ralph Fritsch   +13 more
wiley   +1 more source

Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.: Sorafenib inhibits ABCG2 and overcome irinotecan resistance.

, 2013
International audienceDespite recent advances in the treatment of colorectal cancer (CRC), tumor resistance is a frequent cause of chemotherapy failure.
Leconet, Wilhem, Jarlier, Marta, Evrard, Alexandre, Martineau, Pierre, Mazard, Thibault, Vezzio-Vie, Nadia, Torro, Adeline, del Rio, Maguy, Gongora, Celine, Causse, Annick, Ychou, Marc, Assenat, Eric, Simony, Joelle, Robert, Bruno   +13 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology
Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge. We previously showed that camptothecin induces ubiquitin–proteasome pathway (UPP)‐mediated topoI degradation.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
doaj   +1 more source

Simultaneous Robot‐Assisted Distal Gastrectomy and Radical Cystectomy With a Shared Port Configuration in Situs Inversus Totalis

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Situs inversus totalis complicates minimally invasive surgery, and simultaneous robotic surgery for tumors of different organs is particularly challenging. Case Presentation A 72‐year‐old man with situs inversus totalis receiving androgen blockade for prostate cancer developed a 40‐mm muscle‐invasive bladder tumor undetected on ...
Takaharu Hamada, Shugo Yajima, Shota Umezawa, Gaku Okumura, Tomoki Kimura, Shu Gozu, Madoka Kataoka, Yasukazu Nakanishi, Takahiro Kinoshita, Hitoshi Masuda   +9 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Protective effects of N-acetylcysteine against irinotecan – induced pulmonary toxicity in female albino rats

Zanco Journal of Medical Sciences
Background and objective: Idiopathic pulmonary fibrosis (IPF) is a deadly lung illness characterized by progressive lung fibrosis and deteriorating lung function, with the uncertain origin and few therapeutic options. Chemotherapy such as Irinotecan (IRI)
Hawrin Burhan Khudhur, Ansam Al-Hassani
doaj   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review

, 2021
Treatment with pharmacological drugs for colorectal cancer (CRC) remains unsatisfactory. A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs, creating an urgent issue.
Habano, Wataru, Ozawa, Shogo, Miura, Toshitaka, Terashima, Jun   +3 more
core  

Fruquintinib Plus FOLFIRI/FOLFOX as Second‐Line Therapy in Patients With RAS‐Mutant Metastatic Colorectal Cancer: A Multicenter, Open‐Label, Single‐Arm Phase II Study

MedComm, Volume 7, Issue 11, November 2026.
This phase II trial demonstrates that fruquintinib combined with chemotherapy achieves a median progression‐free survival of 8.08 months and a 52.5% objective response rate as second‐line therapy for RAS‐mutant metastatic colorectal cancer, with a notable 7.14% conversion surgery rate.
Yun Xu, Cong Li, Yiwei Zeng, Yuchen Wu, Yuedi Dai, Xiaopin Ji, Zhe Cui, Xiaodong Zhu, Ming Tang, Ye Xu   +9 more
wiley   +1 more source