Results 31 to 40 of about 446,236 (313)

Ferric reductase-related proteins mediate fungal heme acquisition

eLife, 2022
Heme can serve as iron source in many environments, including the iron-poor animal host environment. The fungal pathobiont Candida albicans expresses a family of extracellular CFEM hemophores that capture heme from host proteins and transfer it across ...
Udita Roy, Shir Yaish, Ziva Weissman, Mariel Pinsky, Sunanda Dey, Guy Horev, Daniel Kornitzer   +6 more
doaj   +1 more source

Exploiting iron-binding proteins for drug delivery.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2019
Currently, many therapies fail due to an insufficient drug dose reaching the target site and high systemic toxicity. Protein-based drug delivery systems that allow an increase in drug concentration at a specific location in the body or predominantly target malignant cells are promising technologies.
M, Bialasek, M, Kubiak, M, Gorczak, A, Braniewska, P, Kucharzewska-Siembieda, M, Krol, B, Taciak   +6 more
openaire   +2 more sources

Identification of an iron–hepcidin complex

, 2008
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the 'iron hormone' which, by interacting with the iron transporter ferroportin,
Bui, T.T.T., Bui, Tam T.T., Rapisarda, C., Evans, R.W., Bui, T, Cammack, R, Drake, AF, Cammack, Richard, Rapisarda, C, Cammack, R., Drake, A, Evans, R W, Farnaud, SJ, Bui, TT, Evans, Robert W, Farnaud, Sebastien, Farnaud, S., Drake, Alex F., Evans, RW, Rapisarda, Chiara, Bui, Tam, Farnaud, Sébastien Jean-Claude, Drake, A.F., Farnaud, S   +23 more
core   +1 more source

FIT-Binding Proteins and Their Functions in the Regulation of Fe Homeostasis

Frontiers in Plant Science, 2019
Iron, as an essential micronutrient, is required by all living organisms. In plants, the deficiency and excess of iron will impair their growth and development.
Huilan Wu, Hong-Qing Ling, Hong-Qing Ling   +2 more
doaj   +1 more source

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
core   +1 more source

Structural Perspectives on Metal Dependent Roles of Ferric Uptake Regulator (Fur)

Biomolecules
Iron is crucial for the metabolism and growth of most prokaryotic cells. The ferric uptake regulator (Fur) protein plays a central role in regulating iron homeostasis and metabolic processes in bacteria.
Sung-Min Kang, Hoon-Seok Kang, Woo-Hyun Chung, Kyu-Tae Kang, Do-Hee Kim   +4 more
doaj   +1 more source

Protein expressions and their immunogenicity from Riemerella anatipestifer cultured in iron restriction medium. [PDF]

PLoS ONE, 2013
Riemerella anatipestifer was cultured in both iron restriction media and normal media. Two-dimensional gel electrophoresis identified 23 proteins that significantly increased in the iron restriction media.
Yifei Yang, Changqin Gu, Yonghong Liao, Qingping Luo, Xueying Hu, Wanpo Zhang, Huabin Shao, Guofu Cheng   +7 more
doaj   +1 more source

Inhibition of lipid peroxidation by the iron-binding protein lactoferrin [PDF]

Biochemical Journal, 1981
Lactoferrin containing physiological amounts of iron is an inhibitor of lipid peroxidation induced by iron(III) salts and ascorbic acid. It might therefore help to protect neutrophils, inflammatory foci and secretions from metal-ion-dependent oxidative damage.
J M, Gutteridge, S K, Paterson, A W, Segal, B, Halliwell   +3 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Abundances of Iron-Binding Photosynthetic and Nitrogen-Fixing Proteins of Trichodesmium Both in Culture and In Situ from the North Atlantic

, 2012
Marine cyanobacteria of the genus Trichodesmium occur throughout the oligotrophic tropical and subtropical oceans, where they can dominate the diazotrophic community in regions with high inputs of the trace metal iron (Fe).
Pratt, Nicola J., Macey, Anna I., Anna I Macey, David J Honey, Moore, C. Mark, Nicola J Pratt, Sophie Richier, Pratt Nicola J., C Mark Moore, Macey Anna I., Bibby Thomas S., Richier Sophie, Honey David J., Moore C. Mark, Honey, David J., Richier, Sophie, Bibby, Thomas S., Thomas S Bibby   +17 more
core   +1 more source