Immunogenicity of Gonococcal Transferrin Binding Proteins during Natural Infections [PDF]
Infection and Immunity, 2004 ABSTRACTIn this study, we examined the immune response during gonococcal infection to the individual transferrin binding proteins by using a quantitative enzyme-linked immunosorbent assay (ELISA). Recombinant transferrin binding protein A (rTbpA) and rTbpB were purified under nondenaturing conditions for use as ELISA antigens.
Gregory A, Price +2 more
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Transferrin Binding Protein B and Transferrin Binding Protein A2 Expand the Transferrin Recognition Range of Histophilus somni [PDF]
Journal of Bacteriology, 2019 Host-restricted pathogens infect a single host species or a narrow range of host species. Histophilus somni , a pathogen that incurs severe economic losses for the cattle industry, infects cattle, sheep, and goats but not other mammals.
Pogoutse, Anastassia K. +1 more
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Conserved Interaction between Transferrin and Transferrin-binding Proteins from Porcine Pathogens
Journal of Biological Chemistry, 2011 Gram-negative porcine pathogens from the Pasteurellaceae family possess a surface receptor complex capable of acquiring iron from porcine transferrin (pTf). This receptor consists of transferrin-binding protein A (TbpA), a transmembrane iron transporter,
Leslie P Silva +2 more
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The structural basis of transferrin sequestration by transferrin-binding protein B [PDF]
Nature Structural & Molecular Biology, 2012 Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB. Here we present the crystal structures of TbpB from N.
Calmettes, Charles +4 more
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First crystal structure of an adduct formed upon reaction of a vanadium compound with human serum transferrin [PDF]
Communications ChemistryThe interaction of vanadium compounds of pharmaceutical interest with metal-transport proteins like human serum transferrin (hTF) is poorly understood. Direct structural evidence identifying vanadium binding sites on hTF is still lacking. Here, the X-ray
Anne-Sophie Banneville +10 more
doaj +2 more sources
Frontiers in Immunology, 2019 The surface transferrin receptor proteins from Neisseria gonorrhoeae have been recognized as ideal vaccine targets due to their critical role in survival in the human male genitourinary tract. Recombinant forms of the surface lipoprotein component of the
Jamie E. Fegan +9 more
doaj +2 more sources
Effects of Receptor Binding on Plasma Half-Life of Bifunctional Transferrin Fusion Proteins
Molecular Pharmaceutics, 2011 In contrast to the wide applications of recombinant bifunctional fusion proteins in clinical usage, the systematic study for the pharmacokinetics (PK) of bifunctional fusion proteins is left blank.
Jennica L Zaro, Wei-Chiang Shen
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Characterization of the diversity and the transferrin-binding domain of gonococcal transferrin-binding protein 2 [PDF]
Infection and Immunity, 1997 The molecular weight heterogeneities of Tbp1 and Tbp2 among a panel of 45 gonococcal isolates were assessed. The tbpB genes from four of these strains were sequenced to characterize the Tbp2 sequence diversity among gonococci. By expressing truncated versions of gonococcal Tbp2, we delimited the extent of Tbp2 necessary for transferrin binding in a ...
C N, Cornelissen +2 more
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