Results 1 to 10 of about 162,073 (298)

Transferrin Binding Protein B and Transferrin Binding Protein A2 Expand the Transferrin Recognition Range of Histophilus somni. [PDF]

J Bacteriol, 2020
Host-restricted pathogens infect a single host species or a narrow range of host species. Histophilus somni , a pathogen that incurs severe economic losses for the cattle industry, infects cattle, sheep, and goats but not other mammals.
Pogoutse AK, Moraes TF.
europepmc   +5 more sources

Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species [PDF]

BMC Microbiology, 2008
Background Transferrin binding protein B (tbpB), an outer membrane lipoprotein, is required for the acquisition of iron from human transferrin. Two tbpB families have been documented in Neisseria meningitidis: an isotype I tbpB gene of 1.8 kb and an ...
Maiden Martin CJ, Harrison Odile B, Rokbi Bachra   +2 more
doaj   +3 more sources

Development of a Human IgG1 Monoclonal Antibody Targeting Transferrin Receptor 1 for Antitumor Drug Delivery [PDF]

Antibodies
Background: Transferrin receptor protein 1 (TfR1) plays a central role in cellular iron uptake and is frequently overexpressed in malignant tumor cells, rendering it an attractive target for tumor-directed therapy and drug delivery.
Tingting Ji, Zhaoyun Zong, Ningyuan Gong, Minghui Yan, Shiyu Chen   +4 more
doaj   +2 more sources

Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. [PDF]

Infect Immun, 2015
ABSTRACT Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae , Neisseriaceae , and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf)
Frandoloso R, Martínez-Martínez S, Calmettes C, Fegan J, Costa E, Curran D, Yu RH, Gutiérrez-Martín CB, Rodríguez-Ferri EF, Moraes TF, Schryvers AB.   +10 more
europepmc   +4 more sources

The structural basis of transferrin sequestration by transferrin-binding protein B. [PDF]

Nat Struct Mol Biol, 2012
Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB. Here we present the crystal structures of TbpB from N.
Calmettes C, Alcantara J, Yu RH, Schryvers AB, Moraes TF.   +4 more
europepmc   +4 more sources

Genome-Wide Association Studies Identify an Association of Transferrin Binding Protein B Variation and Invasive Serogroup Y Meningococcal Disease in Older Adults. [PDF]

J Infect Dis, 2022
Abstract Background Neisseria meningitidis serogroup Y, especially ST-23 clonal complex (Y:cc23), represents a larger proportion of invasive meningococcal disease (IMD) in older adults compared to younger individuals. This study explored the meningococcal genetic variation underlying this association.
Maynard-Smith L, Derrick JP, Borrow R, Lucidarme J, Maiden MCJ, Heyderman RS, Harrison OB.   +6 more
europepmc   +4 more sources

Structural Variations within the Transferrin Binding Site on Transferrin-binding Protein B, TbpB [PDF]

Journal of Biological Chemistry, 2011
Pathogenic bacteria acquire the essential element iron through specialized uptake pathways that are necessary in the iron-limiting environments of the host. Members of the Gram-negative Neisseriaceae and Pasteurellaceae families have adapted to acquire iron from the host iron binding glycoprotein, transferrin (Tf), through a receptor complex comprised ...
Charles Calmettes, Rong-Hua Yu, Leslie P Silva   +2 more
exaly   +4 more sources

Anchor peptide of transferrin-binding protein B is required for interaction with transferrin-binding protein A. [PDF]

J Biol Chem, 2011
Gram-negative bacterial pathogens belonging to the Pasteurellaceae, Moraxellaceae, and Neisseriaceae families rely on an iron acquisition system that acquires iron directly from host transferrin (Tf). The process is mediated by a surface receptor composed of transferrin-binding proteins A and B (TbpA and TbpB).
Yang X, Yu RH, Calmettes C, Moraes TF, Schryvers AB.   +4 more
europepmc   +4 more sources

Both the full-length and the N-terminal domain of the meningococcal transferrin-binding protein B discriminate between human iron-loaded and apo-transferrin [PDF]

FEMS Microbiology Letters, 1998
We have readdressed the ability of the transferrin-binding protein B (TbpB) from Neisseria meningitidis to discriminate between the iron-loaded and the iron-free human transferrin (hTf) by using the BIAcore technology, a powerful experimental technique for the observation of direct interactions between a receptor and its ligands, without the use of ...
Genevieve Renauld-Mongénie, M J Quentin-Millet, David Poncet   +2 more
exaly   +3 more sources

Isolation and expression of the genes coding for the membrane bound transglycosylase B (MltB) and the transferrin binding protein B (TbpB) of the salmon pathogen Piscirickettsia salmonis

Biological Research, 2004
We have isolated and sequenced the genes encoding the membrane bound transglycosylase B (MltB) and the transferring binding protein B (TbpB) of the salmon pathogen Piscirickettsia salmonis.
VIVIAN WILHELM, CARMEN MORALES, RODRIGO MARTÍNEZ, MARIO ROSEMBLATT, LUIS O BURZIO, PABLO D. T VALENZUELA   +5 more
doaj   +4 more sources