Results 21 to 30 of about 162,073 (298)

Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species

Frontiers in Immunology, 2019
The surface transferrin receptor proteins from Neisseria gonorrhoeae have been recognized as ideal vaccine targets due to their critical role in survival in the human male genitourinary tract. Recombinant forms of the surface lipoprotein component of the
Jamie E. Fegan, Jamie E. Fegan, Charles Calmettes, Epshita A. Islam, Sang Kyun Ahn, Somshukla Chaudhuri, Rong-hua Yu, Scott D. Gray-Owen, Trevor F. Moraes, Anthony B. Schryvers   +9 more
doaj   +1 more source

Meningococcal Transferrin-Binding Proteins A and B Show Cooperation in Their Binding Kinetics for Human Transferrin [PDF]

Infection and Immunity, 2005
ABSTRACT Neisseria meningitidis , a causative agent of bacterial meningitis and septicemia, obtains transferrin-bound iron by expressing two outer membrane-located transferrin-binding proteins, TbpA and TbpB. A novel system was developed to investigate the interaction between Tbps and human transferrin.
Stokes, R H, Oakhill, J S, Joannou, C L, Gorringe, A R, Evans, R W   +4 more
openaire   +3 more sources

Analysis of the human Ig isotype response to individual transferrin binding proteins A and B from Neisseria meningitidis [PDF]

FEMS Immunology & Medical Microbiology, 2006
Subcapsular antigens, including transferrin binding proteins, are being considered as potential vaccines against serogroup B meningococci. This study examined the human isotype antibody responses in cases of meningococcal disease to meningococcal TbpA (transferrin binding protein A) and TbpB (transferrin binding protein B) from two strains (SD and ...
A S, Johnson, A R, Gorringe, A J, Fox, R, Borrow, A, Robinson   +4 more
openaire   +3 more sources

Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis [PDF]

, 1994
Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and
Matt Cotten, David Curiel, Curiel, David T., Wagner, Ernst, Ernst Wagner, Cotten, Matt   +5 more
core   +1 more source

Insights into the Bacterial Transferrin Receptor: The Structure of Transferrin-Binding Protein B from Actinobacillus pleuropneumoniae [PDF]

Molecular Cell, 2009
Pathogenic bacteria from the Neisseriaceae and Pasteurellacea families acquire iron directly from the host iron-binding glycoprotein, transferrin (Tf), in a process mediated by surface receptor proteins that directly bind host Tf, extract the iron, and transport it across the outer membrane.
Moraes, Trevor F., Yu, Rong-hua, Strynadka, Natalie C.J., Schryvers, Anthony B.   +3 more
openaire   +2 more sources

Fibrillation of transferrin [PDF]

, 2012
The nature of fibrillar deposits from aqueous solutions of human serum and recombinant human transferrin on mica and carbon-coated formvar surfaces has been ...
Moreton, Ben, Costantini, Giovanni, Scrivens, James H., Sadler, P. J., Scarff, Charlotte A., Giovanni Costantini, Scrivens, James, Charlotte A. Scarff, Peter J. Sadler, Sadler, Peter J., Booyjzsen, Claire, Ben Moreton, Portman, Ian, James H. Scrivens, Claire Booyjz̈sen, Portman, Ian J., Ian Portman   +16 more
core   +1 more source

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology

Haematologica, 2015
Clathrin-dependent endocytosis is an essential cellular process shared by all cell types. Despite this, precisely how endocytosis is regulated in a cell-type-specific manner and how this key pathway functions physiologically or pathophysiologically ...
Yuichi Ishikawa, Manami Maeda, Mithun Pasham, Francois Aguet, Silvia K. Tacheva-Grigorova, Takeshi Masuda, Hai Yi, Sung-Uk Lee, Jian Xu, Julie Teruya-Feldstein, Maria Ericsson, Ann Mullally, John Heuser, Tom Kirchhausen, Takahiro Maeda   +14 more
doaj   +1 more source

Binding Kinetics of Ruthenium Pyrithione Chemotherapeutic Candidates to Human Serum Proteins Studied by HPLC-ICP-MS

Molecules, 2020
The development of ruthenium-based complexes for cancer treatment requires a variety of pharmacological studies, one of them being a drug’s binding kinetics to serum proteins.
Katarina Marković, Radmila Milačič, Stefan Marković, Jerneja Kladnik, Iztok Turel, Janez Ščančar   +5 more
doaj   +1 more source

Production ofNeisseria meningitidisTransferrin-Binding Protein B by RecombinantBordetella pertussis [PDF]

Infection and Immunity, 2001
ABSTRACTNeisseria meningitidisserogroup B infections are among the major causes of fulminant septicemia and meningitis, especially severe in young children, and no broad vaccine is available yet. Because of poor immunogenicity of the serogroup B capsule, many efforts are now devoted to the identification of protective protein antigens.
I, Coppens, S, Alonso, R, Antoine, F, Jacob-Dubuisson, G, Renauld-Mongénie, E, Jacobs, C, Locht   +6 more
openaire   +2 more sources

Niobium uptake and release by bacterial ferric ion binding protein [PDF]

, 2010
Ferric ion binding proteins (Fbps) transport FeIII across the periplasm and are vital for the virulence of many Gram negative bacteria. Iron(III) is tightly bound in a hinged binding cleft with octahedral coordination geometry involving binding to ...
Dominic Campopiano, Sadler, P. J., Harvey, Ian, Ian Harvey, Shi Y, Campopiano D, Peter J. Sadler, Shi, Yanbo, Harvey I, Campopiano, Dominic, Sadler PJ, Yanbo Shi, Sadler, Peter J   +12 more
core   +1 more source