Results 21 to 30 of about 204,163 (265)
mSystems, 2022 Iron and iron-containing compounds are essential for bacterial virulence and host infection. Hemin is an important supplement compound for bacterial survival in an iron-deficient environment.
Kun Cao +6 more
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Flexible iron: disorder in the ironome brings order to protein structure and function
Frontiers in Molecular BiosciencesIron is one of the most abundant elements on earth. The most recognized role of iron in living organisms is its incorporation in the heme-containing protein hemoglobin, which is abundantly found in the red blood cells that facilitate the oxygen ...
Vladimir N. Uversky +4 more
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Ferric reductase-related proteins mediate fungal heme acquisition
eLife, 2022 Heme can serve as iron source in many environments, including the iron-poor animal host environment. The fungal pathobiont Candida albicans expresses a family of extracellular CFEM hemophores that capture heme from host proteins and transfer it across ...
Udita Roy +6 more
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Haematologica, 2019 Loss-of-function mutations in the ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, ABCB7, cause X-linked sideroblastic anemia with ataxia, a phenotype that remains largely unexplained by the proposed role of ABCB7 in exporting ...
Nunziata Maio +4 more
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Host iron binding proteins acting as niche indicators for Neisseria meningitidis. [PDF]
PLoS ONE, 2009 Neisseria meningitidis requires iron, and in the absence of iron alters its gene expression to increase iron acquisition and to make the best use of the iron it has.
Philip W Jordan, Nigel J Saunders
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Structural Perspectives on Metal Dependent Roles of Ferric Uptake Regulator (Fur)
BiomoleculesIron is crucial for the metabolism and growth of most prokaryotic cells. The ferric uptake regulator (Fur) protein plays a central role in regulating iron homeostasis and metabolic processes in bacteria.
Sung-Min Kang +4 more
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FIT-Binding Proteins and Their Functions in the Regulation of Fe Homeostasis
Frontiers in Plant Science, 2019 Iron, as an essential micronutrient, is required by all living organisms. In plants, the deficiency and excess of iron will impair their growth and development.
Huilan Wu +2 more
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Exploiting iron-binding proteins for drug delivery.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2019 Currently, many therapies fail due to an insufficient drug dose reaching the target site and high systemic toxicity. Protein-based drug delivery systems that allow an increase in drug concentration at a specific location in the body or predominantly target malignant cells are promising technologies.
Maciej Białasek +6 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source