Results 21 to 30 of about 446,236 (313)

Phase variation in Myxococcus xanthus yields cells specialized for iron sequestration. [PDF]

PLoS ONE, 2014
Myxococcus xanthus undergoes phase variation during growth to produce predominantly two colony phenotypes. The majority are yellow colonies containing swarm-proficient cells and a minority are tan colonies containing swarm-deficient cells.
Katarzyna Dziewanowska, Matthew Settles, Samuel Hunter, Ingrid Linquist, Faye Schilkey, Patricia L Hartzell   +5 more
doaj   +1 more source

The Non-Canonical Iron-Responsive Element of IRE-tvcp12 Hairpin Structure at the 3′-UTR of Trichomonas vaginalis TvCP12 mRNA That Binds TvHSP70 and TvACTN-3 Can Regulate mRNA Stability and Amount of Protein

Pathogens, 2023
Trichomonas vaginalis is one of the most common sexually transmitted parasites in humans. This protozoan has high iron requirements for growth, metabolism, and virulence. However, iron concentrations also differentially modulate T.
Claudia R. León-Sicairos, Elisa E. Figueroa-Angulo, Jaeson S. Calla-Choque, Rossana Arroyo   +3 more
doaj   +1 more source

Niobium uptake and release by bacterial ferric ion binding protein [PDF]

, 2010
Ferric ion binding proteins (Fbps) transport FeIII across the periplasm and are vital for the virulence of many Gram negative bacteria. Iron(III) is tightly bound in a hinged binding cleft with octahedral coordination geometry involving binding to ...
Dominic Campopiano, Sadler, P. J., Harvey, Ian, Ian Harvey, Shi Y, Campopiano D, Peter J. Sadler, Shi, Yanbo, Harvey I, Campopiano, Dominic, Sadler PJ, Yanbo Shi, Sadler, Peter J   +12 more
core   +1 more source

Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.

PLoS ONE, 2012
BackgroundMembers of the WhiB-like (Wbl) protein family possess iron-sulfur clusters and are implicated in the regulation of developmental processes in Actinomycetes. Mycobacterium tuberculosis possesses seven Wbl proteins.
Laura J Smith, Melanie R Stapleton, Roger S Buxton, Jeffrey Green   +3 more
doaj   +1 more source

Identification and Tetramer Structure of Hemin-Binding Protein SPD_0310 Linked to Iron Homeostasis and Virulence of Streptococcus pneumoniae

mSystems, 2022
Iron and iron-containing compounds are essential for bacterial virulence and host infection. Hemin is an important supplement compound for bacterial survival in an iron-deficient environment.
Kun Cao, Tianlong Zhang, Nan Li, Xiao-Yan Yang, Jianping Ding, Qing-Yu He, Xuesong Sun   +6 more
doaj   +1 more source

Rustless translation [PDF]

, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Hopfner, Karl-Peter
core   +1 more source

Biochemical, Biophysical, and Cellular Investigations of the Interactions of Transferrin Receptor with Transferrin and the Hereditary Hemochromatosis Protein, HFE [PDF]

, 2004
Hereditary hemochromatosis (HH) is a prevalent genetic disorder that results in the daily excess absorption of dietary iron. If untreated this disease leads to systemic organ failure and death. HH is caused by mutations to the gene coding for a protein
Giannetti, Anthony Michael
core   +1 more source

Iron metabolism in trypanosomatids, and its crucial role in infection. [PDF]

, 2010
Iron is almost ubiquitous in living organisms due to the utility of its redox chemistry. It is also dangerous as it can catalyse the formation of reactive free radicals - a classical double-edged sword.
Taylor, MC, Kelly, JM
core   +1 more source

Flexible iron: disorder in the ironome brings order to protein structure and function

Frontiers in Molecular Biosciences
Iron is one of the most abundant elements on earth. The most recognized role of iron in living organisms is its incorporation in the heme-containing protein hemoglobin, which is abundantly found in the red blood cells that facilitate the oxygen ...
Vladimir N. Uversky, Vladimir N. Uversky, Gloria C. Ferreira, Gloria C. Ferreira, Gloria C. Ferreira   +4 more
doaj   +1 more source

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis

Haematologica, 2019
Loss-of-function mutations in the ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, ABCB7, cause X-linked sideroblastic anemia with ataxia, a phenotype that remains largely unexplained by the proposed role of ABCB7 in exporting ...
Nunziata Maio, Ki Soon Kim, Gregory Holmes-Hampton, Anamika Singh, Tracey A. Rouault   +4 more
doaj   +1 more source