Results 291 to 300 of about 51,265 (314)
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Iron chelating agents with clinical potential
Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences, 1992Synopsis:Iron is a critically important metal for a wide variety of cellular events. The element holds this central position by virtue of its facile redox chemistry and the high affinity of both redox states (iron II and iron III) for oxygen. These same properties also render iron toxic when levels exceed the normal binding capacity of the cell.
Robert C. Hider +2 more
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Iron mobilization from ferritin by chelating agents
Journal of Inorganic Biochemistry, 1980The release of iron from horse spleen ferritin by the chelating agents desferrioxamine B, rhodotorulic acid, 2,3-dihydroxybenzoate, 2,2'-bipyridyl and pyridine-2-aldehyde-2-pyridyl hydrazone (Paphy) has been studied in vitro. Ferritin prepared by classical procedures involving thermal denaturation releases its iron less effectively than ferritin ...
Robert R. Crichton +2 more
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The Behaviour of Iron Chelating Agents with Plants
Journal of Experimental Botany, 1965The absorption by normal and iron-deficient bean plants of Fe and of ethylene diamine-bis-(orthohydroxyphenylacetic acid) (EDHPA) is described; and the metabolism in plants of this chelating agent and of ethylenediaminetetra-acetic acid (EDTA) is examined using 14C-labelled compounds.
C. P. Lloyd-Jones, D. G. Hill-Cottingham
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Mobilization of ferritin iron in erythroblasts by chelating agents
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985Intracellular ferritin in newt (Triturus cristatus) erythroblasts was accessible to the chelating effects of EDTA and pyridoxal phosphate. EDTA (0.5-1 mM) promoted release of radioactive iron from ferritin of pulse-labelled erythroblasts during chase incubation, but its continuous presence was not necessary for ferritin iron mobilization.
Janice A. Mooney-Frank +2 more
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Chelating Agents for the Treatment of Systemic Iron Overload
Current Medicinal Chemistry, 2012The first successful therapeutic iron chelator was desferrioxamine which was introduced in the late 1960's by Ciba (now Novartis). Desferrioxamine has been an extremely successful compound having received the MMW "Pharmaceutical of the year" award for 1991. It is a life saving and a life - prolonging drug which improves the quality of life.
Ma, Yongmin +3 more
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EFFECT OF AN IRON‐CHELATING AGENT ON LYMPHOCYTE PROLIFERATION
Australian Journal of Experimental Biology and Medical Science, 1984SummaryThe effect of the iron‐chelating: agent desferrioxamine on lymphocyte proliferation has been studied. Desferrioxamine at concentrations of 15 μM totally inhibited the proliferation of Concanavalin A‐stimulated lymphocytes, whereas iron‐saturated desferrioxamine was ineffective.
P Badenoch-Jones +3 more
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Therapeutic iron-chelating agents
1994The ability of iron to exist in two redox states and to bind oxygen has rendered the metal a critical status in living systems. Iron is the essential cofactor of numerous enzymes and oxygen-binding proteins. These two properties are utilized widely by iron-containing proteins.
R.C. Hider, S. Singh
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Interaction of Iron Chelating Agents with Clay Minerals
Soil Science Society of America Journal, 2004Organic ligands play an important role in metal transport and availability in soils. However, their interaction with the solid phase of soils has not been sufficiently investigated. Two efficient Fe chelators were investigated in this study, as free ligands as well as Fe complexes: (i) the microbial siderophore ferrioxamine B (desferrioxamine B [DFOB ...
Yona Chen +2 more
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Iron mobilization from transferrin by therapeutic iron chelating agents
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012The bacteriostatic activity of the transferrin family has been known since the early 1960's. The possession of high affinity iron(III)-binding sites and the existence of a specific membrane-bound receptor, have led to the present understanding of serum transferrin acting as the major iron transporter between cells in vertebrate systems.
Evans, Robert W. +2 more
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Potential of iron chelators as effective antiproliferative agents
Canadian Journal of Physiology and Pharmacology, 1997Initially the impetus to develop iron (Fe) chelators for clinical use was based upon the need for a drug to treat Fe-overload diseases such as beta-thalassemia. However, it has become clear that Fe chelators may be useful for the treatment of a wide variety of disease states, including cancer, malaria, and free radical mediated injury.
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