Results 301 to 310 of about 51,265 (314)
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Iron-chelating agents and the reductive removal of iron from transferrin
Biochemical Pharmacology, 1980Abstract 2-Formylpyridine thiosemicarbazone, a strong iron (II) and iron(III)-chelating agent, removed iron from transferrin only under reductive conditions. The reaction required a bicarbonate-labilizing anion such as nitrilotriacetate in order for reduction and release of iron to the thiosemicarbazone to occur.
David H. Petering, Else Ankel
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Determination of Iron Chelating Agents by Analytical Methods: A Review
Critical Reviews in Analytical Chemistry, 2019Acute iron poisoning and chronic iron overload consequences in significant morbidity and mortality worldwide. Treatment of acute iron poisoning and chronic iron overload can be challenging and care providers are often tackled with management dilemmas. Iron chelating agents are commonly prescribed for patients with iron deficiency anemia. In this review
Sandip D. Firke +4 more
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Chelating agent differences in ferrous iron determinations
Journal of Plant Nutrition, 1984Abstract Experiments were conducted to test the ability of ferrous iron (Fe2+) chelating agents to discriminate between Fe2+ and ferric iron (Fe3+), to determine ranges of Fe2+ detection in reactions, to determine interactions of chelating agents with phosphorus (P) which is common in plant tissue, and to evaluate some of the complexities of ...
E. E. Pierson, R. B. Clark
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Iron chelators as therapeutic agents for the treatment of cancer
Critical Reviews in Oncology/Hematology, 2002A wide variety of studies in vitro, in vivo, and in clinical trials have demonstrated that the chelator currently used to treat iron overload disease, desferrioxamine, has anti-proliferative effects against both leukemia and neuroblastoma. However, the efficacy of desferrioxamine is severely limited due to its poor ability to permeate cell membranes ...
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Effect of iron-chelating agents on inhibitors of ribonucleotide reductase
Biochemical Pharmacology, 1981Abstract Ribonucleotide reductase from Ehrlich tumor cells is inhibited by hydroxyurea (HU), guanazole (GZ), pyrazolo-imidazole (IMPY), 1-formylisoquinoline thiosemicarbazone (IQ), 4-methyl-5-aminoisoquinoline thiosemicarbazone (MAIQ). and the dialdehydes of inosine and 5′-deoxyinosine.
Linda S. Lasater +2 more
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Inhibition of bacteria by lactoferrin and other iron-chelating agents
Biochimica et Biophysica Acta (BBA) - General Subjects, 1968When not fully saturated with iron, bovine, human and goat lactoferrins were bacteriostatic for Bacillus stearothermophilus and Bacillus subtilis in both the presence and absence of trace amounts of metals. Bovine lactoferrin inhibited the germination of spores and the growth of vegetative cells of B. stearothermophilus.
J.D. Oram, B. Reiter
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British Journal of Haematology, 1982
Fifteen compounds with a high affinity to ferric iron have been screened for in vivo iron-chelating efficiency in a rat model. One of the most potent of these drugs was ethylenediamine-N,N'-bis(o-hydroxyphenylglycine) (EHPG). EHPG-induced iron excretion was up to 8 times higher than iron excretion induced by identical doses of desferrioxamine (DF ...
Gabriela Link +2 more
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Fifteen compounds with a high affinity to ferric iron have been screened for in vivo iron-chelating efficiency in a rat model. One of the most potent of these drugs was ethylenediamine-N,N'-bis(o-hydroxyphenylglycine) (EHPG). EHPG-induced iron excretion was up to 8 times higher than iron excretion induced by identical doses of desferrioxamine (DF ...
Gabriela Link +2 more
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New Chelating Agents for Trivalent Iron
Science, 1953F. C. Bersworth, Stanley Chaberek
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Therapeutic Use of Chelating Agents in Iron Overload
1995Elemental iron, like molecular oxygen, is a highly toxic substance that is nevertheless essential for life. Therefore, like oxygen, complex biochemical systems have evolved for its safe delivery, transport, and utilization. Iron absorption in the human gut is a highly regulated process that depends in part on total body iron stores (FLanagan 1990 ...
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Mobilization of iron from ferritin by chelating agents
Biochemistry, 1968Leon. Pape +3 more
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