Results 101 to 110 of about 48,493 (287)

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Ultrahigh Strength and Exceptional Work Hardening in a Hierarchical‐Structured Alloy via Hetero‐Interface‐Mediated Twinning

Advanced Science, EarlyView.
This study presents a novel strategy for achieving exceptional work hardening in ultrahigh‐strength alloys by designing hierarchically heterogeneous dual‐phase (HHDP) structures, where hetero‐deformation‐induced strain gradients activate deformation twinning.
Yitong Yang, Jingyu Pang, Hongwei Zhang, Jiajia Shen, Zhenqiang Xing, Yuan Sun, Aimin Wang, J. P. Oliveira, Wei Wang, Zengbao Jiao   +9 more
wiley   +1 more source

A Mesoporous Calcium Peroxide Nanocuboid with High Tumor Accumulation Across Biological Barriers for High Efficacy Tumor Therapy

Advanced Science, EarlyView.
The ferroheme (FH) and exceedingly small magnetic iron oxide nanoparticles (IO) loaded mesoporous calcium peroxide nanocuboid (MCPNC) with conjugation of hyaluronic acid (HA) possesses exceptional capability of tumor accumulation, and enhances therapeutic efficacy of tumors based on the mechanism of promoting a positive feedback loop of Fenton reaction
Qingdeng Fan, Min Wang, Jie Lin, Ya Huang, Jing Yang, Jiaoyang Zhu, Bin Ren, Li Sun, Zongheng Li, Aochi Liu, Wei Xiong, Zhenni Wei, Lin Huang, Chenggong Yan, Ge Wen, Zhao Chen, Xiaoyuan Chen, Zheyu Shen   +17 more
wiley   +1 more source

2D Multivariate‐Metal‐Organic Frameworks (2D‐M2OF) for High Yield Ammonia Synthesis from Nitrate

Advanced Energy Materials, EarlyView.
2D multivariate‐metal‐organic frameworks (2D‐M2OFs) enable efficient ammonia electrosynthesis from nitrates under ambient conditions. Incorporating Co, Ni, Mn, and Ag into BHT‐based 2D‐MOF creates a synergistic catalytic architecture that enhances nitrate reduction via surface hydrogen co‐adsorption.
Shahriar Namvar, Arash Namaeighasemi, Syed Ibrahim Gnani Peer Mohamed, Ugochukwu Nwosu, Mohammad Arham Khan, Nikita Gupta, Abdul Motakkaber Sarkar, Taha Raja, Ahmad Jaradat, Ilias Papailias, Ksenija Glusac, Samira Siahrostami, Siamak Nejati, Amin Salehi‐Khojin   +13 more
wiley   +1 more source

Iron body stores in patients treated with red-cell transfusions

Zdravniški Vestnik, 2007
Background: Consequence of chronic transfusion therapy is a secondary iron overload, which adversely affects the heart, liver and endocrine glands. This can be minimized by iron chelating therapy.
Uroš Mlakar
doaj  

Inhibition of Slc39a14/Slc39a8 reduce vascular calcification via alleviating iron overload induced ferroptosis in vascular smooth muscle cells

Cardiovascular Diabetology
Background Vascular calcification (VC) is an independent risk factor for cardiovascular diseases. Recently, ferroptosis has been recognised as a novel therapeutic target for cardiovascular diseases.
Yierpani Aierken, Huqiang He, Runwen Li, Zipeng Lin, Tongjie Xu, Li Zhang, Ya Wu, Yong Liu   +7 more
doaj   +1 more source

Advanced Synthesis and Fabrication Strategies for 2D Mesoporous Carbon Materials in Energy Storage and Conversion

Advanced Energy and Sustainability Research, EarlyView.
The rising demand for efficient energy systems has spotlighted 2D mesoporous carbon materials due to their high surface area, tunable porosity, and electrical conductivity. This article explores synthesis methods (template‐assisted, chemical vapor deposition), fabrication techniques (electrospinning, freeze‐drying), and applications in batteries ...
Pariksha Bishnoi, Samarjeet Singh Siwal, Nirankar Singh, Manju Kumari Thakur, Phil Hart, Vijay Kumar Thakur   +5 more
wiley   +1 more source

Enhanced iron removal from liver parenchymal cells in experimental iron overload: liposome encapsulation of HBED and phenobarbital administration [PDF]

, 1983
YE Rahman, EA Cerny, EH Lau, Carnes Ba
openalex   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Supramolecular Probe for Monitoring Lysosomal Ferritinophagy to Facilitate the Early Diagnosis of Parkinson's Disease

Aggregate, EarlyView.
A supramolecular fluorescent probe, TPE‐4B/4Q[7], was designed to target lysosomes. The restriction of intramolecular rotation effect mediated by Q[7] enhances the fluorescence of TPE‐4B/4Q[7], enabling selective detection of Fe3+ with a detection limit of 1.23 × 10⁻⁶ M.
Shiqin Zhou, Bo Xiao, Jiamin Chen, Jinming Zhu, Xia Ran, Zuoji Liu, Chaozhong Li, Li Wang, Xinai Cui, Rong Li, Guangwei Feng, Jian Feng   +11 more
wiley   +1 more source