Results 101 to 110 of about 129,076 (346)

PATHOHISTOLOGICAL PECULIARITIES OF THE FORMATION OF IRON OVERLOAD SYNDROME IN PATIENTS WITH STEATOHEPATITIS DEPENDING ON ITS ETIOLOGY

, 2021
T. Antofiichuk, И. С. Давыденко, О. С. Хухліна, N.P. Antofiichuk, V. S. Haidychuk   +4 more
openalex   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia

Frontiers in Immunology
BackgroundThe hematopoietic ecosystem comprises both cellular components such as hematopoietic stem cells (HSCs) and immune cells as well as non-cellular components including iron.
Feifei Yang, Shulin Luo, Dan Yang, Xiaoxi Cui, Dongyue Zhang, Hao Wang, Yifei Li, Wanzhen Xie, Lina Wang, Lina Wang, Xiuqun Zhang, Guoguang Zheng, Guoguang Zheng, Xuezhong Zhang   +13 more
doaj   +1 more source

New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia

Haematologica, 2019
Genetic iron-overload disorders, mainly hereditary hemochromatosis and untransfused β-thalassemia, affect a large population worldwide. The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading ...
Jing Liu, Wei Liu, Yin Liu, Yang Miao, Yifan Guo, Haoyang Song, Fudi Wang, Hongyu Zhou, Tomas Ganz, Bing Yan, Sijin Liu   +10 more
doaj   +1 more source

T1 at 1.5T and 3T compared with conventional T2* at 1.5T for cardiac siderosis [PDF]

, 2015
Background: Myocardial black blood (BB) T2* relaxometry at 1.5T provides robust, reproducible and calibrated non-invasive assessment of cardiac iron burden.
A Meloni, A Meloni, A Pepe, A. John Baksi, AJ Baksi, AJ Fleming, B Modell, D Dabir, David N. Firmin, DJ Pennell, DJ Pennell, DJ Pennell, DM Sado, DM Sado, Dominique Auger, DR Messroghli, DR Messroghli, Dudley J. Pennell, G Abbruzzese, Gillian C. Smith, H Guo, JB Porter, JC Moon, JC Wood, JM Bland, JP Carpenter, JP Carpenter, JP Carpenter, JW Eaton, LJ Anderson, M Fontana, MA Tanner, MA Tanner, MA Westwood, Mohammed H. Alam, P Kellman, P Kellman, P Kirk, P Kirk, P Kirk, P Kirk, P Storey, Peter Drivas, Rick Wage, S Bull, S Roujol, SK Piechnik, T He, T He, Taigang He, TC Wong, TC Wong, TD Karamitsos, Vassilis Vassiliou, W Collins, X Gao, Y Feng, Yanqiu Feng   +57 more
core   +3 more sources

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Distribution and quantitation of skin iron in primary haemochromatosis: correlation with total body iron stores in patients undergoing phlebotomy [PDF]

, 2014
Measurement of the concentration of iron in the skin, if correlated with total body iron stores, may enable better informed decisions on when to initiate, change or stop therapy in hereditary heamochromatosis.
Barreiros, M. Alexandra, Filipe, Paulo, Fleming, Rita, Gonçalves, Afonso, Morlière, Patrice, Pinheiro, Teresa, Santus, René, Silva, João N., Silva, Raquel   +8 more
core   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study. [PDF]

, 2020
BackgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada.Materials and methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross ...
Acton, Ronald T, Adams, Paul C, Barton, James C, Eckfeldt, John H, Gordeuk, Victor R, Harris, Emily L, Harrison, Helen, McLaren, Christine E, McLaren, Gordon D, Reboussin, David M, Wiener, Howard H   +10 more
core  

Iron overload in transfusion-dependent survivors of hemoglobin Bart’s hydrops fetalis [PDF]

, 2018
Ali Amid, Shiyi Chen, Uma H. Athale, Karen Charpentier, Manuela Merelles‐Pulcini, Isaac Odame, Melanie Kirby‐Allen   +6 more
openalex   +1 more source