Results 251 to 260 of about 121,405 (297)
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Clinica Chimica Acta, 2005
Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the complex mechanisms of normal and disordered iron homeostasis.
Siah, C., Trinder, D., Olynyk, John
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Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the complex mechanisms of normal and disordered iron homeostasis.
Siah, C., Trinder, D., Olynyk, John
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Iron Deficiency, Iron Overload
Annals of Internal Medicine, 1972Excerpt To the editor: In his recent editorial (1) Dr. V. F. Fairbanks reviewed the tests available for iron deficiency.
J, Sorbie, L S, Valberg
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Acta Clinica Belgica, 2000
African iron overload has been recognised in sub-Saharan Africa for seventy years. The condition is distinct from the well-characterised HLA-linked haemochromatosis described in Caucasians. Increased dietary iron intake predisposes to the condition. Recent evidence suggest that African iron overload may be caused by an interaction between increased ...
I, Kasvosve +3 more
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African iron overload has been recognised in sub-Saharan Africa for seventy years. The condition is distinct from the well-characterised HLA-linked haemochromatosis described in Caucasians. Increased dietary iron intake predisposes to the condition. Recent evidence suggest that African iron overload may be caused by an interaction between increased ...
I, Kasvosve +3 more
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Hematology, 2001
Abstract Transfusion therapy for inherited anemias and acquired refractory anemias both improves the quality of life and prolongs survival. A consequence of chronic transfusion therapy is secondary iron overload, which adversely affects the function of the heart, the liver and other organs.
J P, Kushner, J P, Porter, N F, Olivieri
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Abstract Transfusion therapy for inherited anemias and acquired refractory anemias both improves the quality of life and prolongs survival. A consequence of chronic transfusion therapy is secondary iron overload, which adversely affects the function of the heart, the liver and other organs.
J P, Kushner, J P, Porter, N F, Olivieri
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Clinics in Liver Disease, 2002
Because hepatic siderosis is a frequent finding, there is a risk of making it trite when elaborating the pathology report. Iron is increasingly considered an important cofactor of morbidity. Its finding in hepatic cells must be recognized, indicated, qualified, quantified, and interpreted.
Bruno, Turlin, Yves, Deugnier
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Because hepatic siderosis is a frequent finding, there is a risk of making it trite when elaborating the pathology report. Iron is increasingly considered an important cofactor of morbidity. Its finding in hepatic cells must be recognized, indicated, qualified, quantified, and interpreted.
Bruno, Turlin, Yves, Deugnier
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New England Journal of Medicine, 2013
Both hemochromatosis and β-thalassemia are caused by a deficiency of hepcidin, which represses expression of ferroportin at the surface of cells that export iron into the blood. Studies suggest that repressing expression of a hepcidin inhibitor ameliorates disease in mouse models.
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Both hemochromatosis and β-thalassemia are caused by a deficiency of hepcidin, which represses expression of ferroportin at the surface of cells that export iron into the blood. Studies suggest that repressing expression of a hepcidin inhibitor ameliorates disease in mouse models.
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Iron deficiency and iron overload
Critical Reviews in Oncology/Hematology, 1985An up to date review of our knowledge of human iron metabolism is given including problems of iron balance, internal transport, and intracellular mechanisms. Current knowledge of the iron proteins is summarized and this background is used in discussing the pathophysiology of iron deficiency and overload, together with the internal derangements such as ...
Allan Jacobs, A.V. Hoffbrand
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Seminars in Hematology, 2002
Iron overload is common in rural sub-Saharan African populations that have the custom of drinking a traditional fermented beverage with high iron content. As with both excessive alcohol exposure and HFE hemochromatosis, hepatic portal fibrosis and micronodular cirrhosis are prominent sequelae of African iron overload.
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Iron overload is common in rural sub-Saharan African populations that have the custom of drinking a traditional fermented beverage with high iron content. As with both excessive alcohol exposure and HFE hemochromatosis, hepatic portal fibrosis and micronodular cirrhosis are prominent sequelae of African iron overload.
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Acta Paediatrica, 1989
Halliday, J. W. (The Liver Group, Department of Medicine, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia). Inherited iron overload.Several inherited forms of iron overload have been described. It is now accepted that HC, usually regarded as a disease of adult life, is an inherited disorder, hence all first degree relatives must ...
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Halliday, J. W. (The Liver Group, Department of Medicine, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia). Inherited iron overload.Several inherited forms of iron overload have been described. It is now accepted that HC, usually regarded as a disease of adult life, is an inherited disorder, hence all first degree relatives must ...
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Postgraduate Medicine, 1973
The variable criteria used in diagnosing hemochromatosis have resulted in considerable confusion in the literature. How does one separate the alcoholic with cirrhosis and secondary iron overload from the patient with “familial hemochromatosis” who happens to drink too much? And if phlebotomy is the way to treat hemochromatosis, why not use this therapy
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The variable criteria used in diagnosing hemochromatosis have resulted in considerable confusion in the literature. How does one separate the alcoholic with cirrhosis and secondary iron overload from the patient with “familial hemochromatosis” who happens to drink too much? And if phlebotomy is the way to treat hemochromatosis, why not use this therapy
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