Results 71 to 80 of about 306,202 (319)
Heme-responsive DNA Binding by the Global Iron Regulator Irr from Rhizobium leguminosarum*
Journal of Biological Chemistry, 2010 Heme, a physiologically crucial form of iron, is a cofactor for a very wide range of proteins and enzymes. These include DNA regulatory proteins in which heme is a sensor to which an analyte molecule binds, effecting a change in the DNA binding affinity ...
C. Singleton +6 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló +5 more
wiley +1 more source
Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.
Tutorials in Quantitative Methods for Psychology, 2012 Many research designs require the assessment of inter-rater reliability (IRR) to demonstrate consistency among observational ratings provided by multiple coders.
Kevin A. Hallgren
semanticscholar +1 more source
Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
British Journal of Clinical Pharmacology, EarlyView.Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
CRITICAL ANALYSIS OF THE CONCEPT OF INTERNAL RATE OF RETURN OF INVESTMENTS PROJECTS
Вестник университета, 2018 The article deals with to the critical analysis of the internal rate of return, which represents one of the traditional most frequently used indicators of financial effectiveness of investment projects, allowing investors to sense relative yield from ...
A. Kuznetsov
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer +4 more
wiley +1 more source
Jurnal TeknikaAir merupakan sumber daya alam yang sangat vital dan diperlukan untuk menentukan keberlanjutan kehidupan seluruh makhluk hidup di muka bumi ini. Masalah yang dihadapi adalah sistem air bersih ke daerah tempat tinggal penduduk tidak lancer.
Edelbertus Lusius Hardi +2 more
doaj +1 more source
International Journal of Urban Sustainable Development, 2018 The Government of DKI Jakarta plans to free the city from slum dwellings by 2020. In the quest to mitigate floods from Jakarta, the government relocated about 25,533 people; 5,725 households and 5,379 business units from 12 slum areas between 2014 and ...
Puput Ichwatus Sholihah, Chen Shaojun
doaj +1 more source
Decoding Emotional Signatures of Ethical Ads: An Analysis of Actor‐Viewer Synchrony
Journal of Consumer Behaviour, EarlyView.ABSTRACT We examine whether ethical advertisements differ from conventional ads in their on‐screen emotional signatures and whether those signatures transfer to actor‐viewer synchrony. Study 1 analyses 138 professionally produced YouTube ads using Automated Facial Expression Recognition (AFER) and Convolutional Neural Networks (CNN) to quantify actor ...
Vik Naidoo, Nicolas Hamelin
wiley +1 more source
Jurnal TeknikaKetersediaan air minum merupakan salah satu kebutuhan dasar dan hak sosial ekonomi masyarakat yang harus dipenuhi oleh Pemerintah. Perlu dilakukan Analisis kelayakan Investasi Pengembangan Sistem Penyediaan Air Minum (SPAM) Dari Mata Air Cibulakan ...
Hari Sundana +2 more
doaj +1 more source