Results 71 to 80 of about 5,894 (297)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
Proton and Au-ion irradiation induced damage and hardening in ferritic/martensitic steel
Nuclear Materials and Energy, 2021 Ferritic/martensitic (F/M) steel was irradiated by proton and Au-ion at 400 °C to investigate the irradiation damage and hardening behavior. For the samples irradiated by proton, dislocation loops and dislocation lines were found in F/M steels and the ...
Ke Shi +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Machine learning predictions of irradiation embrittlement in reactor pressure vessel steels
npj Computational Materials, 2022 Irradiation increases the yield stress and embrittles light water reactor (LWR) pressure vessel steels. In this study, we demonstrate some of the potential benefits and risks of using machine learning models to predict irradiation hardening extrapolated ...
Yu-chen Liu +20 more
doaj +1 more source
Properties of Potassium Doped and Tantalum Containing Tungsten after Heavy Ion Irradiation
Crystals, 2023 Tungsten potassium (WK) alloy has been reported as one of the ideal plasma-facing materials (PFMs). Tantalum alloying is a good method to improve the mechanical properties of tungsten.
Juan Du +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Xe Ion Irradiation-Induced Microstructural Evolution and Hardening Effect of Nickel-Base Superalloy [PDF]
, 2021 The nickel-base superalloy Hastelloy N was irradiated using 1 MeV Xe20+ and 7 MeV Xe26+ ions with displacement damage ranging from 0.5 dPa to 10 dPa at room temperature (RT). The irradiated Ni-based superalloy was characterized with transmission electron
DeHui Li +5 more
core +1 more source
Hardening of KCl by Electron and Gamma Irradiation
Journal of Applied Physics, 1963 Measurements of the flow stress and F-band coloration have been made at room temperature on a number of different samples of KCl as a function of gamma and electron irradiation. The rate of increase of flow stress with irradiation is found to be greater (or smaller) in those samples and for those irradiation conditions for which the coloring rate is ...
W. A. Sibley, E. Sonder
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Metals, 2019 Under irradiations, mechanical performance of nuclear alloys would degrade due to irradiation induced defects. Different strengthening methods can play a different role in the evolution of the defects.
Cheng Chen +4 more
doaj +1 more source