Results 101 to 110 of about 52,798 (213)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients

Hemodialysis International, EarlyView.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior   +8 more
wiley   +1 more source

Effectiveness of galcanezumab versus topiramate, amitriptyline, and other select traditional oral migraine preventives with evidence of efficacy: 3‐Month results from the TRIUMPH study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To compare the 3‐month effectiveness of galcanezumab with select traditional oral migraine preventive (TOMP) medications recommended by scientific societies (TOMP efficacy subset) and with the most frequently used individual TOMP medications.
Shivang Joshi, Cristina Tassorelli, Manjit Matharu, Taoufik Alsaadi, Carlos Vallarino, Lars Viktrup, Maurice Vincent, Rebecca L. Robinson   +7 more
wiley   +1 more source

Diagnosis and management of irritable bowel syndrome. [PDF]

Aust Prescr
Morrison S, Talley N.
europepmc   +1 more source

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

International Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Application of neuromodulation techniques in irritable bowel syndrome. [PDF]

Front Neurosci
Zhang Y, Gao L, Zhang X, Sun W, Wang M, Zhang T, Wang X.   +6 more
europepmc   +1 more source

Online Group Hypnotherapy for Irritable Bowel Syndrome-a Pilot Study. [PDF]

Neurogastroenterol Motil
Lövdahl J, Törnblom H, Ringström G, Palsson OS, Simrén M.   +4 more
europepmc   +1 more source

The Gut Microbiome as a Therapeutic Target in Alopecia Areata: Not Yet Part of the Patient Treatment Plan

International Journal of Dermatology, EarlyView.
ABSTRACT Interest in the gut microbiome as a therapeutic target for treating alopecia areata (AA) has grown considerably. However, existing evidence remains limited and inconsistent. Currently, there is insufficient evidence to recommend microbiome‐directed testing and therapies to patients with AA.
Eric McMullen, Deema Abdel Hafeez, Nikhil Pai, Laurence Mainville, Shireen Dumont, Narachai Julanon, Romy Shenderey, Grace Xiong, Shahnawaz Towheed, Jeffrey Donovan   +9 more
wiley   +1 more source

Guidance for Grading the Evidence in Quantitative Umbrella Reviews

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Background Umbrella reviews (URs) synthesize evidence across multiple systematic reviews and meta‐analyses to inform decision‐making. However, evaluating and integrating evidence certainty across overlapping and sometimes conflicting meta‐analyses remains a major methodological challenge of URs, limiting the reliability of conclusions ...
Hanan Khalil, Ritin Fernandez, Patraporn Bhatarasakoon, Kim Sears, Dawid Piper, Jennifer Stone, Cindy Stern, Kate Kynoch   +7 more
wiley   +1 more source

Irritable bowel syndrome with diarrhea: time to change practice? [PDF]

Curr Opin Gastroenterol
Caranfil C, Bertin L, Zingone F.
europepmc   +1 more source