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Muscle and Nerve, 2015
Isaacs syndrome is a peripheral nerve hyperexcitability (PNH) syndrome that presents as continuous motor activity. Clinical findings include cramps, fasciculations, and myokymia. Electrodiagnosis plays a key role in diagnosis by demonstrating after-discharges on nerve conduction studies, and fasciculation potentials, myokymic discharges, neuromyotonic ...
Aiesha Ahmed, Zachary Simmons
exaly +4 more sources
Isaacs syndrome is a peripheral nerve hyperexcitability (PNH) syndrome that presents as continuous motor activity. Clinical findings include cramps, fasciculations, and myokymia. Electrodiagnosis plays a key role in diagnosis by demonstrating after-discharges on nerve conduction studies, and fasciculation potentials, myokymic discharges, neuromyotonic ...
Aiesha Ahmed, Zachary Simmons
exaly +4 more sources
Isaacs' syndrome as a potassium channelopathy of the nerve
Muscle and Nerve, 2002Isaacs' syndrome (acquired neuromyotonia) is an antibody-mediated potassium channel disorder (channelopathy). The target channel proteins of the antigens are voltage-gated potassium channels (VGKCs), especially dendrotoxin-sensitive fast potassium channels. The suppression of voltage-gated outward K(+) current by antibodies induces hyperexcitability of
Kimiyoshi Arimura +2 more
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Late-onset seropositive Isaacs’ syndrome after Guillain–Barré syndrome
Neuromuscular Disorders, 2009Acquired neuromyotonia, or Isaacs' syndrome, has been described in combination with a variety of other autoimmune disorders; however there has never been a report of seropositive Isaacs' syndrome in a patient with a history of Guillain-Barré syndrome (GBS).
Kenneth A Myers
exaly +3 more sources
Isaacs' syndrome: Clinical and electrophysiological response to gabapentin
Muscle and Nerve, 2006AbstractA patient with Isaacs' syndrome had generalized muscle spasms, twitching, and progressive muscle stiffness for 21 years. Electrodiagnostic study showed continuous spontaneous motor‐unit activity and the presence of M‐wave afterdischarges. He responded dramatically to treatment with carbamazepine but developed a drug rash; his treatment was ...
Upinder K Dhand
exaly +3 more sources
British Journal of Hospital Medicine, 2008
A 57-year-old retired factory worker was admitted to the accident and emergency department complaining of a 3-month history of painful stiffness of his hands and toes. In addition he complained of generalized weakness, numbness and a tingling sensation of both his upper and lower limbs as well as weight loss.
Neel, Sharma +2 more
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A 57-year-old retired factory worker was admitted to the accident and emergency department complaining of a 3-month history of painful stiffness of his hands and toes. In addition he complained of generalized weakness, numbness and a tingling sensation of both his upper and lower limbs as well as weight loss.
Neel, Sharma +2 more
openaire +3 more sources
2022
We describe a patient who presented with fatigue and pulling sensation in his lower limbs. He had continuous muscle contractions over his trunk (myokymia) which pointed towards the diagnosis of Isaacs syndrome which was confirmed by strongly positive CASPR2 antibodies in blood.
ALEX REBELLO +5 more
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We describe a patient who presented with fatigue and pulling sensation in his lower limbs. He had continuous muscle contractions over his trunk (myokymia) which pointed towards the diagnosis of Isaacs syndrome which was confirmed by strongly positive CASPR2 antibodies in blood.
ALEX REBELLO +5 more
openaire +1 more source
A case report of neuromyotonia (Isaacs syndrome)
Journal of Clinical Images and Medical Case Reports, 2022A 58-year-old man presented with numbness and muscle twitching in the lower limbs since 2.5 months and muscle twitching in the upper limbs since 2 days. In early April 2015, the patient noticed numbness and coolness in the toes of both his feet without any obvious cause, and occasional muscle twitching in the left calf. He developed pain in both calves
Xiaojia Sun +3 more
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Thymoma in the Offspring of a Patient With Isaacs Syndrome
Journal of Pediatric Hematology/Oncology, 2007Thymoma is a diagnosis most often made in adults, and is exceedingly rare in children. The diagnosis of a thymoma is often times linked to an autoimmune process, and the association of thymoma and myasthenia gravis in children has been previously reported.
Don, Coulter, Stuart, Gold
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