Results 241 to 250 of about 23,803 (294)
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Isatin Conjugates as Antibacterial Agents: A Brief Review.
Medicinal chemistry, 2022Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human health and well-being and put a persistent strain on the health care system.
F. Hassan +7 more
semanticscholar +1 more source
Archiv der Pharmazie, 2022
A novel series of triazole‐linked isatin‐indole‐3‐carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally designed and synthesized as potential xanthine oxidase inhibitors.
Atamjit Singh +12 more
semanticscholar +1 more source
A novel series of triazole‐linked isatin‐indole‐3‐carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally designed and synthesized as potential xanthine oxidase inhibitors.
Atamjit Singh +12 more
semanticscholar +1 more source
Alkylation of isatins with trichloroacetimidates
Organic & Biomolecular Chemistry, 2022N-Alkylation or O-alkylation of isatins can be achieved utilizing trichloroacetimidate electrophiles with the major product being controlled by solvent effects. These reactions provide access to N-alkyl isatins, versatile scaffolds which are often employed in synthesis.
Nilamber A. Mate +3 more
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Reaction of -Vinyloxyalkylamines with Isatin [PDF]
Russian Journal of Organic Chemistry, 2003 3-(ω-Vinyloxyalkylimino)-2,3-dihydroindol-2-ones and 3-(vinyloxyphenylimino)-2,3-dihydroindol-2-ones were synthesized in 34-93% yield by reactions of ω-aminoalkyl and aminophenyl vinyl ethers with isatin.
N. A. Lobanova +3 more
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Journal of Photochemistry, 1987
Abstract Isatin does not show fluorescence or phosphorescence under any conditions. After excitation it undergoes rapid intersystem crossing to the triplet state (τ = 340 ns in deaerated benzene). This triplet state is capable of hydrogen abstraction, yielding a product analogous to pinacol, isatide.
A. Graness, B. Seidel, G. Haucke
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Abstract Isatin does not show fluorescence or phosphorescence under any conditions. After excitation it undergoes rapid intersystem crossing to the triplet state (τ = 340 ns in deaerated benzene). This triplet state is capable of hydrogen abstraction, yielding a product analogous to pinacol, isatide.
A. Graness, B. Seidel, G. Haucke
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Recent advances in isatin hybrids as potential anticancer agents
Archiv der Pharmazie, 2020The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin‐based anticancer agents, such as semaxanib, sunitinib, nintedanib, and hesperadin, are already in use or under ...
Zhen Ding, Minfeng Zhou, Cheng Zeng
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Synthesis of Isatin Derivatives.
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
E. G. Mesropyan +3 more
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Chemistry – An Asian Journal, 2020
AbstractA general method for the construction of trifluoromethylated 2‐quinolinones has been established herein by using a trifluoromethylative ring expansion of isatin with trifluorodiazoethane. The strategy provides a platform for the rapid synthesis of a wide range of substituted 3‐hydroxy‐4‐trifluoromethyl‐2‐quinolinones.
Ekta Gupta +6 more
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AbstractA general method for the construction of trifluoromethylated 2‐quinolinones has been established herein by using a trifluoromethylative ring expansion of isatin with trifluorodiazoethane. The strategy provides a platform for the rapid synthesis of a wide range of substituted 3‐hydroxy‐4‐trifluoromethyl‐2‐quinolinones.
Ekta Gupta +6 more
openaire +2 more sources
Isatin–azole hybrids and their anticancer activities
Archiv der Pharmazie, 2020Isatin and azole moieties, which have the ability to form various noncovalent interactions with different therapeutic targets, are common pharmacophores in drug development.
Yani Hou +3 more
semanticscholar +1 more source
A REVIEW ON ISATIN AND ITS DERIVATIVES: SYNTHESIS, REACTIONS AND APPLICATIONS
Journal of advanced scientific research, 2021Isatin, also known as 1H-Indole-2, 3-Dione, is an eight-carbon containing endogenous compound found in nature. Erdmann and Laurent synthesized isatin in 1840, before it was discovered in nature. It is versatile and distributed in tissues and body fluids.
Priyanka V. Gandhi +3 more
semanticscholar +1 more source