Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities.
Moataz A. Shaldam +11 more
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Developing Heterogeneous Porous 3D-Printed SiO2-Pd-K2SiO3 Monolithic Catalyst via Surface MOF Growth and Pyrolysis for the Synthesis of Antitumoral Isatins [PDF]
PharmaceuticsBackground/Objectives: The isatin nucleus is a privileged scaffold in drug discovery, particularly due to its proven relevance in anticancer research. Developing reusable heterogeneous 3D catalysts for drug synthesis represents a critical challenge in ...
Alexandrina Druta +9 more
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Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity [PDF]
Molecules, 2023 Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and ...
Hua Zhao, Yufen Zhao
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Base-Catalyzed Reaction of Isatins and (3-Hydroxyprop-1-yn-1-yl)phosphonates as a Tool for the Synthesis of Spiro-1,3-dioxolane Oxindoles with Anticancer and Anti-Platelet Properties [PDF]
MoleculesAn approach to the synthesis of phosphoryl substituted spiro-1,3-dioxolane oxindoles was developed from the base-catalyzed reaction of various isatins with (3-hydroxyprop-1-yn-1-yl)phosphonates.
Arina V. Murashkina +12 more
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Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryTwo series of N-alkyl isatins and N-alkyl indoles varying in size of the alkyl group were synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
Kaitlyn N. Alcorn +3 more
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Chemistry Proceedings, 2021 Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties.
Nguyen Minh Tri +11 more
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Molecules, 2023 The purpose of this work was to prepare new isatin- and monothiomalondiamide-based indole derivatives, as well as to study the properties of the new compounds.
Victor V. Dotsenko +5 more
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5-(Trifluoromethoxy)isatin [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 THE TITLE COMPOUND [SYSTEMATIC NAME: 5-(trifluoro-meth-oxy)-1H-indole-2,3-dione], C9H4F3NO3, crystallized with two mol-ecules in the asymmetric unit. Inter-molecular N-H⋯O hydrogen bonds link the mol-ecules to form layers parallel to the ab plane. In addition, π-π stacking inter-actions are observed with a centroid-centroid distance of 3.721 (1) Å. The
M. Schutte +3 more
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Synthesis of substituted isatins [PDF]
Tetrahedron Letters, 2013 Isatins are valuable intermediates for heterocyclic chemistry. Most of the common methods for their production are less than adequate when the number and lipophilicity of substituents on the targeted isatin are increased. Our group desired such molecules and identified an alternative method for their production.
Larry L, Klein, Michael D, Tufano
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Anthranilic acids from isatin: an efficient, versatile and environmentally friendly method
Anais da Academia Brasileira de Ciências, 2015 This paper describes the preparation of a series of 16 anthranilic acids in yields ranging from 51 to 97%, by treating the isatins with NaOH and H2O2. Independently of the nature of the substituent on the aromatic ring, the reactions were complete in 15 ...
GABRIEL F. RIO +3 more
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