Results 11 to 20 of about 1,179 (184)

1-[(1-{[(1S,2R,6R,8R,9S)-4,4,11,11-Tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methyl}-1H-1,2,3-triazol-4-yl)methyl]-2,3-dihydro-1H-indole-2,3-dione

IUCrData, 2017
The title compound,C23H26N4O7, adopts a Z-shaped conformation, with a dihedral angle between the mean planes of the dihydroindole and triazole rings of 70.36 (7)°.
Fatima-Zahrae Qachchachi, Joel T. Mague, Youssef Kandri Rodi, Amal Haoudi, Abdeslem Ben-Tama, El Mokhtar Essassi   +5 more
doaj   +1 more source

Antinociceptive effect and mechanism of action of isatin, N-methyl isatin and oxopropyl isatin in mice

Life Sciences, 2016
There has been growing interest in the synthesis of new derivatives from isatin, found in Isatis genus. Our objectives were to characterize the antinociceptive mechanism of action of isatin, N-methyl-isatin (MI) and N-methyl-3-(2-oxopropyl)-3-hydroxy-2-oxindole (MOI).Substances (0.1-10mg/kg, p.o.) were studied in chemical (paw licking induced by ...
Thais Biondino Sardella Giorno, Bárbara Vasconcellos da Silva, Angelo da Cunha Pinto, Patricia Dias Fernandes   +3 more
openaire   +2 more sources

Design, Synthesis, and Biological Evaluation of 2-Mercaptobenzoxazole Derivatives as Potential Multi-Kinase Inhibitors

Pharmaceuticals, 2023
A series of 12 compounds was designed and synthesized, based on 2-mercaptobenzoxazole derivatives containing either the substituted benzenes 4a–d, substituted isatins 5a–f, or heterocycles 6a–b.
Mohammed M. Alanazi, Saleh Aldawas, Nawaf A. Alsaif   +2 more
doaj   +1 more source

Spiro[benzo[е]pyrano[3,2-c][1,2]oxathiin-4,3’-indolil]-3-carbonitrile 5,5-dioxides: synthesis and the biological activity study

Журнал органічної та фармацевтичної хімії, 2019
The development of medicines with several pharmacological activities, including the analgesic, anti-inflammatory and antimicrobial properties, is one of the challenging tasks of modern medicinal chemistry. Aim.
Galyna V. Grygoriv, Dmitry A. Lega, Igor A. Zupanets, Sergii K. Shebeko, S. M. Zimin, Iryna L. Starchikova, L. A. Shemchuk   +6 more
doaj   +1 more source

4-Chloro-1H-indole-2,3-dione

IUCrData, 2016
The title compound, C8H4ClNO2, has two planar molecules in the asymmetric unit, with the non-H atoms showing a mean deviation from planarity of 0.015 and 0.022 Å, respectively.
Rashid M. Juma, James A. Golen, David R. Manke   +2 more
doaj   +1 more source

4-Iodo-1H-indole-2,3-dione

IUCrData, 2016
The title compound, C8H4INO2, is an almost planar molecule having an r.m.s. deviation of 0.03 Å for all non-H atoms. In the crystal, molecules dimerize through pairs of N—H...O hydrogen bonds. These inversion dimers are linked through pairs of weak I...O
James A. Golen, David R. Manke
doaj   +1 more source

3D-Printing of Capsule Devices as Compartmentalization Tools for Supported Reagents in the Search of Antiproliferative Isatins

Pharmaceuticals, 2023
The application of high throughput synthesis methodologies in the generation of active pharmaceutical ingredients (APIs) currently requires the use of automated and easily scalable systems, easy dispensing of supported reagents in solution phase organic ...
Camilla Malatini, Carlos Carbajales, Mariángel Luna, Osvaldo Beltrán, Manuel Amorín, Christian F. Masaguer, José M. Blanco, Silvia Barbosa, Pablo Taboada, Alberto Coelho   +9 more
doaj   +1 more source

Synthesis, characterization, and biological activity of a new class of dialkylphosphorylhydrazone derivatives of isatin

Química Nova, 2014
Sixteen dialkylphosphorylhydrazones were synthesized by condensation of phosphorylhydrazines with substituted isatins. Products were characterized by FTIR, ¹H-NMR, 13C-NMR, and 31P-NMR.
Letícia Silotti Zampirolli, Marcela Jacques de Lemos, Vinícius Tomaz Gonçalves, Marco Andre Alves de Souza, Sonia Regina de Souza, Victor Marcos Rumjanek, João Batista Neves DaCosta   +6 more
doaj   +1 more source

Six-component synthesis and biological activity of novel spiropyridoindolepyrrolidine derivatives: A combined experimental and theoretical investigation

Frontiers in Chemistry, 2022
Petasites hybridus rhizome water extract was used as green media for the preparation of Ag/Fe3O4/CdO@multi-walled carbon nanotubes magnetic nanocomposites (Ag/Fe3O4/CdO@MWCNTs MNCs), and its activity was evaluated by using in the one-pot multicomponent ...
Zinatossadat Hossaini, Marziyeh Mohammadi, Fatemeh Sheikholeslami-Farahani   +2 more
doaj   +1 more source

6-Fluoro-1H-indole-2,3-dione

IUCrData, 2016
The title compound, C8H4FNO2, has a single, almost planar, molecule in the asymmetric unit, with the non-H atoms having a mean deviation from planarity of 0.042 Å. Intermolecular N—H...O hydrogen bonds result in infinite chains along [100]. The molecules
James A. Golen, David R. Manke
doaj   +1 more source