Results 31 to 40 of about 1,179 (184)
Molecules, 2013 An efficient approach for the synthesis of 3-substituted-3-hydroxy-2-oxindoles has been achieved via an aldol reaction of α,β-unsaturated ketones and isatins using arginine as an organocatalyst.
Tingting Yan +4 more
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Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis
European Journal of Organic Chemistry, EarlyView.In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley +1 more source
4,6-Dichloro-1H-indole-2,3-dione
IUCrData, 2016 The title compound, C8H3Cl2NO2, has a single, almost planar, molecule in the asymmetric unit, with the non-H atoms having a mean deviation from planarity of 0.027 Å. In the crystal, N—H...O hydrogen bonds form infinite C(4) chains along [100].
Ronald J. Mastrolia +2 more
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Journal of Applied Toxicology, EarlyView.ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü +3 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay +4 more
wiley +1 more source
Investigation of factors affecting ozone yellowing in denim products
Coloration Technology, EarlyView.Abstract The aim of this study was to determine the source of ozone yellowing observed in denim trousers and to identify the most appropriate process flow to minimise it. For this purpose, standard pre‐washing, stone washing, and hypochlorite bleaching processes were applied to denim trousers.
Rıza Atav +4 more
wiley +1 more source
6-Bromo-1H-indole-2,3-dione hemihydrate
IUCrData, 2016 The title compound, C8H4BrNO2·0.5H2O, has a single planar molecule in the asymmetric unit with the non-H atoms having a mean deviation from planarity of 0.028 Å.
John R. Turbitt +2 more
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Reductive 1,2-Arylation of Isatins
Organic Letters, 2022 We report an intermolecular Ni-catalyzed reductive coupling of aryl iodides and isatins to form 3-hydroxyoxindoles. In contrast to common metal-mediated methods, sec-butanol is used as a mild stoichiometric reductant resulting in benign waste products.
Nasim, A. +3 more
openaire +3 more sources
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Five novel series of isatin–Schiff base derivatives are synthesized and evaluated for neuroprotective and anti‐infective potential. The compounds demonstrate exceptional, reversible, and competitive monoamine oxidase inhibition, with chloro‐substitutions dictating isoform selectivity.
Marthinus J. Jooste +4 more
wiley +1 more source
The chemistry of isatins: a review from 1975 to 1999
Journal of the Brazilian Chemical Society, 2001 Isatins (1H-indole-2,3-dione) are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds, such as indoles and quinolines, and as raw material for drug synthesis.
Silva Joaquim F. M. da +2 more
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