Results 61 to 70 of about 1,179 (184)

Antidiabetic and Cytotoxicity Studies of Novel Quinazolinone–1,3,4‐Thiadiazole Molecular Hybrids

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
ABSTRACT In the treatment of diabetes mellitus (DM), inhibition of carbohydrate‐hydrolysing enzymes, such as α‐amylase, has emerged as a promising therapeutic strategy. In the present study, a series of quinazolinone‐1,3,4‐thiadiazole molecular hybrids were designed, synthesized and biologically evaluated for their antidiabetic potential.
Prishani Kisten, Pule Seboletswe, Gobind kumar, Nontobeko Gcabashe, Neha Manhas, Ankit, Almahi Idris, Md. Shahidul Islam, René Khan, Parvesh Singh   +9 more
wiley   +1 more source

Antidiabetic Evaluation of Thiosemicarbazone Analogs Through α‐Amylase Inhibition Complemented With Computational Studies

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Thiosemicarbazones were evaluated for antidiabetic activity via α‐amylase inhibition. Compound 6g showed two‐fold greater potency than acarbose. Benzaldehyde‐ and ketone‐derived analogues were most active, while isatin and furan derivatives were less effective. Several compounds displayed antioxidant activity. Docking highlighted hydrogen bonding and π–
Neha Manhas, Gobind Kumar, Ankit, Nagaraju Kerru, Pule Seboletswe, Nontobeko Gcabashe, Almahi Idris, Md. Shahidul Islam, Talent Makhanya, Parvesh Singh   +9 more
wiley   +1 more source

A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

Molecules, 2020
The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation.
Guido Gambacorta, David C. Apperley, Ian R. Baxendale   +2 more
doaj   +1 more source

Effect of Structure on Charge Distribution in the Isatin Anions in Aprotic Environment: Spectral Study

Molecules, 2017
Five isatin anions were prepared by deprotonation of initial isatins in aprotic solvents using basic fluoride and acetate anions (F− and CH3COO−). The F− basicity is sufficient to deprotonate isatin NH hydrogen from all the studied compounds.
Pavol Tisovský, Róbert Šandrik, Miroslav Horváth, Jana Donovalová, Klaudia Jakusová, Marek Cigáň, Róbert Sokolík, Anton Gáplovský, Martin Gáplovský, Juraj Filo   +9 more
doaj   +1 more source

Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization

Beilstein Journal of Organic Chemistry, 2012
A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai, Bo Liang, Corey R. J. Stephenson   +2 more
doaj   +1 more source

Enantioselective addition of diphenyl phosphonate to ketimines derived from isatins catalyzed by binaphthyl-modified organocatalysts

Beilstein Journal of Organic Chemistry, 2016
Chiral binaphthyl-modified squaramide-catalyzed enantioselective addition of diphenyl phosphonate to ketimines derived from isatins has been achieved. This method affords practical and efficient access to chiral 3-amino-3-phosphonyl-substituted oxindole ...
Hee Seung Jang, Yubin Kim, Dae Young Kim
doaj   +1 more source

Molecular Iodine: A Powerful Catalyst for the Knoevenagel Condensation of Isatins with Malononitrile

Journal of Chemistry, 2013
Molecular iodine has been used as an efficient catalyst for an improved and rapid condensation of isatins with malononitrile in excellent yields. The significant features of the iodine-catalyzed Knoevenagel condensation are operational simplicity ...
Xiao Juan Yang, Yong Sen Zhang
doaj   +1 more source

One-pot four-component reaction for convenient synthesis of functionalized 1-benzamidospiro[indoline-3,4'-pyridines]

Beilstein Journal of Organic Chemistry, 2014
The one-pot four-component reaction of benzohydrazide (2-picolinohydrazide), acetylenedicarboxylate, isatins and malononitrile (ethyl cyanoacetate) with triethylamine as base catalyst afforded functionalized 1-benzamidospiro[indoline-3,4'-pyridines] in ...
Chao Wang, Yan-Hong Jiang, Chao-Guo Yan
doaj   +1 more source

Spectroscopic studies on Isatin-3-Semicarbazone and Isatin-3-Thiosemicarbazone

Global Journal of Pure and Applied Sciences, 2004
The configurations of semi-and thiosemicarbazone derivatives of isatin are assigned by means of 1H and 13C NMR Spectroscopy including NOE difference spectra, IR and electronic spectral data of these compounds are also reported and discussed. The electron impact (EI), fast atom bombardment (FAB) and negative ion chemical ionization (NICI) mass spectra ...
openaire   +3 more sources

Organocatalytic asymmetric allylic amination of Morita–Baylis–Hillman carbonates of isatins

Beilstein Journal of Organic Chemistry, 2012
The investigation of a Lewis base catalyzed asymmetric allylic amination of Morita–Baylis–Hillman carbonates derived from isatins afforded an electrophilic pathway to access multifunctional oxindoles bearing a C3-quaternary stereocenter, provided with ...
Hang Zhang, Shan-Jun Zhang, Qing-Qing Zhou, Lin Dong, Ying-Chun Chen   +4 more
doaj   +1 more source