Results 71 to 80 of about 1,179 (184)

Review On Isatin and its Antidiabetic Isatin Scaffolds

Isatin (1H-indole-2,3-dione) is a well-known heterocyclic compound that has gained considerable attention in medicinal chemistry due to its broad range of biological activities. The molecule possesses a bicyclic structure consisting of a benzene ring fused with a five-membered heterocyclic ring containing two carbonyl groups at the C-2 and C-3 ...
openaire   +2 more sources

An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines

Beilstein Journal of Organic Chemistry, 2012
Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines.
Zhiyuan Ma, Feng Ni, Grace H. C. Woo, Sie-Mun Lo, Philip M. Roveto, Scott E. Schaus, John K. Snyder   +6 more
doaj   +1 more source

Efficient one-pot catalyst-free synthesis of novel coumarin- spiro[indoline-3,4'-pyran] conjugates via three-component domino reaction in aqueous medium

Green Chemistry Letters and Reviews, 2019
A simple, efficient, eco-friendly and catalyst-free procedure was developed for the construction of novel coumarin-spiro[indoline-3,4'-pyran] conjugates via three-component reactions of various synthetic beta-ketoesters with isatins and malononitrile in ...
Adil Omar, Keyume Ablajan
doaj   +1 more source

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

Beilstein Journal of Organic Chemistry, 2014
The regioselective three-component condensation of azomethine ylides derived from isatins and α-amino acids with acrylamides or aroylacrylic acids as dipolarophiles has been realized through a one-pot 1,3-dipolar cycloaddition protocol.
Tatyana L. Pavlovskaya, Fedor G. Yaremenko, Victoria V. Lipson, Svetlana V. Shishkina, Oleg V. Shishkin, Vladimir I. Musatov, Alexander S. Karpenko   +6 more
doaj   +1 more source

A Survey of Isatin Hybrids and their Biological Properties

Molecular Diversity
The emergence of diverse infections worldwide, which is a serious global threat to human existence, necessitate the urgent development of novel therapeutic candidates that can combat these diseases with efficacy. Isatin, a secondary metabolite from tryptophan is considered a privileged scaffold and favorable pharmacophore with a unique structural ...
Vanessa Asoh Shu, Donatus Bekindaka Eni, Fidele Ntie-Kang   +2 more
openaire   +2 more sources

Synthesis of heterocycles based on azomethine ylides from α-amino acids (or amines) and carbonyl compounds. [PDF]

Beilstein J Org Chem
Berezhnaya EV, Ponyaev AI, Boitsov VM, Stepakov AV.   +3 more
europepmc   +1 more source

Catalytic enantioselective synthesis of azahelicenes via cascade Pictet-Spengler reaction and dehydrogenative aromatization. [PDF]

Nat Commun
Qin T, Xie W, Yang X.
europepmc   +1 more source

Bifunctional Monothiosquaramide-Catalyzed Enantioselective Addition of Masked Acyl Cyanide to Isatins: Umpolung Strategy for the Total Synthesis of (<i>S</i>)-(-)-Dioxibrassinin and (<i>R</i>)-(+)-Spirobrassinin. [PDF]

Org Lett
Reis FAA, Sathish M, Silva BV, Marra RKF, Magalhães LO, Rawal VH, Nachtigall FM, Santos LS.   +7 more
europepmc   +1 more source

Solvent controlled synthesis of spiro and nonspiro indolinones with aminonaphthoquinone and pyrazolone moieties. [PDF]

Sci Rep
Pezhman H, Mohammadizadeh MR, Saberi D, Janczak J.   +3 more
europepmc   +1 more source

Recent advances of azomethine ylides for the synthesis of natural and synthetic bioactive pyrrolidines and spiropyrrolidines. [PDF]

RSC Adv
Paira P, Chakrabarty R, Deb Barman P, Singh B, Paira R.   +4 more
europepmc   +1 more source