Results 31 to 40 of about 258,774 (251)
Frontiers in Physiology, 2019 BackgroundNeonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for
Claudia Sisa +9 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A vékonybelek ischaemia-reperfusiós károsodása
, 2021 Az ischaemia-reperfusios károsodás egy multifaktoriális probléma, amelyek közül a kulcsponti eseményeket emeltem ki. Az ischaemia során a véráramlás elégtelensége, ezáltal az oxigén és egyéb nutritív faktorok hiánya dominál, míg az anyagcseretermékek ...
Szabó, Bence
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Which pathways trigger the role of complement in ischaemia/reperfusion injury?
Frontiers in Immunology, 2012 Investigations into the role of complement in ischaemia/reperfusion injury have identified common effector mechanisms that depend on the production of C5a and C5b-9 through the cleavage of C3.
Conrad Anthony Farrar +3 more
doaj +1 more source
Austral Journal of Veterinary Sciences, 2023 Owners of working equids in Morocco, as in other low and middle-income countries hobble their animals around the pastern using different materials (wire, baling twine and ropes). Resulting wounds are very common and can cause serious damage. Some hobbles
Rabiaa Azelhak +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2007 The early diagnosis of myocardial ischaemia is problematic in patients with ESRD (end-stage renal disease). The aim of the present study was to determine whether IMA (ischaemia-modified albumin) increases during dobutamine stress and detects myocardial ...
Pellerin, D. +7 more
core +1 more source
Platelet Activating Factor Synthesis and Metabolism in Intestinal Ischaemia-Reperfusion Injury
Mediators of Inflammation, 1994 The object of this study was to characterize the synthesis and metabolism of platelet activating factor (PAF) by intestinal mucosa subjected to ischaemia–reperfusion injury.
M. J. Mangino +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Antegrade coeliac axis reconstruction for Chronic Mesenteric Ischaemia : a case series [PDF]
, 2009 The management of chronic mesenteric ischaemia remains a compelling challenge for many vascular surgeons. Over the past four decades, several reports have demonstrated encouraging results following revascularisation of the splanchnic arteries.
Tait, William F. +3 more
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