Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils [PDF]
Neuroscience Research 41(3): 233-241 (2001), 2007 The time course of oxidative damage in different brain regions was investigated in the gerbil model of transient cerebral ischemia. Animals were subjected to both common carotid arteries occlusion for 5 min. After the end of ischemia and at different reperfusion times (2, 6, 12, 24, 48, 72, 96 h and 7 days), markers of lipid peroxidation, reduced and ...
arxiv
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]
, 2017 Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat +6 more
core +3 more sources
Advanced Biology, EarlyView.Definition of study groups, including young individuals (n = 7 mean age: 28.7 years), middle aged individuals (n = 14 mean age: 62.3 years) and elderly individuals (n = 14 mean age: 83.9 years). Condensed workflow including sample preparation (sample lysis and tryptic digestion), mass spectrometric measurements and subsequent data and statistical ...
Britta Eggers +10 more
wiley +1 more source
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils [PDF]
Brain Research 927(2): 212-215 (2002), 2007 Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils.
arxiv
Myocardial infarct-sparing effect of ischemic preconditioning abrogated in cirrhotic rat through involvement of mitochondrial permeability transition pore [PDF]
, 2012 Despite all studies undertaken mechanism of cirrhotic cardiomyopathy the role of cirrhosis on ischemia-reperfusion (I/R) injury and ischemic preconditioning (IPC) phenomenon hasn't been explored yet.
Dehpour, A.R. +4 more
core
Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study. [PDF]
, 2011 Background. Diabetes is a risk factor for delayed graft function in kidney transplantation, and hyperglycemia increases ischemia reperfusion injury in animal models. Methods.
Dang, Kim +3 more
core +5 more sources
The response of the hepatocyte to ischemia [PDF]
Liver International, 2007 Abstract:Background: Ischemia‐reperfusion (I/R) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice, in spite of several attempts to solve the problem.Aims: To evaluate the response of the hepatocyte to ischemiaMethods: Published data are thus revised.Results: The response of the ...
Peralta, C. (C.) +4 more
openaire +5 more sources
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.
Physiological Reviews, 2008 Mitochondria play an important role in cell death and cardioprotection. During ischemia, when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium (Ca(2+)), which further accelerates ATP depletion.
E. Murphy, C. Steenbergen
semanticscholar +1 more source
Case of a 96‐year‐old woman with tilt of the subjective vertical axis
Annals of Clinical and Translational Neurology, EarlyView.
Markus A. Hobert +4 more
wiley +1 more source