Results 61 to 70 of about 655,132 (312)

miR-127 protects proximal tubule cells against ischemia/reperfusion : identification of Kinesin family member 3B as miR-127 target [PDF]

, 2012
Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.
Cuppen, E., Bernhard Brüne, David Sáenz-Morales (139779), Konstantinos Stamatakis (139787), Stamatakis, K., Ramos, Edurne, Elisa Conde, Edurne Ramos (139777), Ramos, E., García Bermejo, María Laura, Blanco-Sanchez, I., Edwin Cuppen, Sáenz-Morales, David, Brune, B., Conde, E., Ignacio Blanco-Sánchez (139784), Bermejo, M.L., Luis del Peso (133134), Edwin Cuppen (9902), Stamatakis Andriani, Konstantinos, Stamatakis, Konstantinos, Peso, Luis del, del Peso, Luis, María Laura García Bermejo (139790), Saenz-Morales, D., Conde, Elisa, Konstantinos Stamatakis, María Laura García Bermejo, Edurne Ramos, Aguado-Fraile, Elia, Aguado-Fraile, E., del Peso, L., Ignacio Blanco-Sánchez, Blanco-Sánchez, Ignacio, Brüne, Bernhard, Bernhard Brüne (131193), Cuppen, Edwin, Elia Aguado-Fraile (139775), Elisa Conde (139781), Elia Aguado-Fraile, Luis del Peso, David Sáenz-Morales   +41 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E, Eridan Rocha-Ferreira, Eridan eRocha-Ferreira, Mariya eHristova, Hristova, M, Mariya Hristova   +5 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm [PDF]

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
MacAllister, R.J., Loukogeorgakis, S.P., Panagiotido, A.T., Yellon, D.M., Deanfield, J.E.   +4 more
core  

Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2021
Background: High sensitivity CRP (hs-CRP) has attracted intense interest in risk assessment. We aimed to explore its prognostic value in patients with acute myocardial infarction (AMI).Methods and Results: We enrolled 4,504 consecutive AMI patients in ...
Xiaoyuan Zhang, Xiaoyuan Zhang, Shanjie Wang, Shanjie Wang, Shaohong Fang, Shaohong Fang, Bo Yu, Bo Yu   +7 more
doaj   +1 more source

Myocarcial ischemia.

Japanese Circulation Journal, 1985
As one of the cause of acute myocardial ischemia, coronary vasospasm has attracted attention increasingly in clinical cardiology. We developed animal model of coronary vasospasm associated with transient myocardial ischemia by administration of histamine or serotonin in atherosclerotic miniature swine.
openaire   +3 more sources

The wisdom in ISCHEMIA

Indian Heart Journal, 2020
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) study was published recently demonstrating that over a period of 3.3 years a routine invasive approach along with optimised medical therapy (OMT) was not superior to OMT alone in patients with stable coronary artery disease and at least moderate ...
Thomas, Boban, Hassan, Imad
openaire   +3 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source