Results 51 to 60 of about 655,132 (312)

Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation [PDF]

, 2013
The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during ...
Haitham Mutlak, Paulus, Patrick, Mutlak, Haitham, Johannes Holfeld, Haitham Mutlak (452006), Sabine Tacke (318720), David Stay (452009), Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Christin Reissig, Pia Alexandra Ockelmann, Reissig, Christin, Zacharowski, Kai, Tacke, Sabine, Bertram Scheller (318724), Stay, David, Bertram Scheller, Ockelmann, Pia Alexandra, Scheller, Bertram, Kai Zacharowski (77285), Sabine Tacke, Johannes Holfeld (318725), Patrick Paulus (318716), Anja Urbschat, Kai Zacharowski, Christin Reissig (452008), Anja Urbschat (318726), David Stay, Pia Alexandra Ockelmann (452007)   +29 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) dampens hepatic ischemia-reperfusion injury [PDF]

, 2011
Recent work has demonstrated that the formation of platelet neutrophil complexes (PNCs) affects inflammatory tissue injury. Vasodilator-stimulated phosphoprotein (VASP) is crucially involved into the control of PNC formation and myocardial reperfusion ...
Birk, Philipp, Morote-Garcia, Julio C., Rosenberger, Peter, Peter Rosenberger, Eldh, Therese, Andreas Straub, Klemens König, Philipp Birk, Therese Eldh, König, Klemens, Julio C Morote-Garcia, Straub, Andreas, Köhler, David, David Köhler   +13 more
core   +1 more source

Focal Geometry and Characteristics of Erosion-Prone Coronary Plaques in vivo Angiography and Optical Coherence Tomography Study

Frontiers in Cardiovascular Medicine, 2021
Objective: This study compared focal geometry and characteristics of culprit plaque erosion (PE) vs. non-culprit plaques in ST-segment elevated myocardial infarction (STEMI) patients in whom optical coherence tomography (OCT) identified PE as the cause ...
Muhua Cao, Muhua Cao, Tianyu Wu, Tianyu Wu, Jiawei Zhao, Jiawei Zhao, Zhuo Du, Zhuo Du, Zhuozhong Wang, Zhuozhong Wang, Lulu Li, Lulu Li, Guo Wei, Guo Wei, Jinwei Tian, Jinwei Tian, Haibo Jia, Haibo Jia, Gary S. Mintz, Bo Yu, Bo Yu   +20 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Effect of propranolol on regional myocardial function in anesthetized open-chest dogs with myocardial ischemia [PDF]

, 1978
Effects of propranolol on ischemic segmental function were studied in anesthetized open-chest dogs. Two segment-length gauges were used for measuring the regional myocardial function: one was sutured on to the left ventricular surface perfused by the ...
Yoshida, Hidenori, Ikenaga, Toyotake, Ueda, Minoru, Ogino, Yasuhiro, Haraoka, Shoichi, Tawara, Ritsuya, Yoshioka, Nobuhiko, Saito, Daiji   +7 more
core   +1 more source

Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension

Journal of Translational Medicine
Background Abnormal glycolytic metabolism plays a significant role in pulmonary vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH), yet the specific mechanisms remain unclear.
Xuan Gao, Youli Fan, Guijia Wang, Jiangjiang Xu, Runwei Deng, Jiangwei Song, Binfeng Sun, Yongbing Wang, Zixuan Wu, Ruyi Jia, Jing Huang, Huiyu He, Lei Gao, Yihao Zhang, Na Sun, Bingxiang Wu   +15 more
doaj   +1 more source

Inhibition of microRNA-183 expression resists human umbilical vascular endothelial cells injury by upregulating expression of IRS1

Drug Delivery, 2019
Our study aims to investigate the effect of microRNA-183 (miR-183) on human umbilical vascular endothelial cells (HUVECs) injury by targeting IRS1. HUVECs injury was induced by oxidized low-density lipoprotein (ox-LDL).
Yingying Zhang, Yefei Zhan, Dandan Liu, Bo Yu   +3 more
doaj   +1 more source

The Effect of Blood Pressure Variability on Coronary Atherosclerosis Plaques

Frontiers in Cardiovascular Medicine, 2022
Hypertension is one of the most important risk factors for coronary heart disease (CHD). The regulation of blood pressure plays a significant role in the development and prognosis of CHD.
Yue Liu, Yue Liu, Xing Luo, Xing Luo, Haibo Jia, Haibo Jia, Bo Yu, Bo Yu   +7 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source