Results 31 to 40 of about 550,814 (265)

Effect of Puerarin on Expression of Fas/FasL mRNA in Pulmonary Injury induced by Ischemia-Reperfusion in Rabbits

Natural Product Communications, 2015
The effect of puerarin (Pur) on expressions of Fas/FasL mRNAs in pulmonary ischemia and reperfusion injury (PIRI) in rabbit was investigated. The sole side lung ischemia and reperfusion model was used.
Mengxiao Zheng, Dong Song, Ziyin Luo, Zhongqiu Lu, Yiming Wu, Wantie Wang   +5 more
doaj   +1 more source

Persistent Cigarette Smoking Attenuates Plaque Stabilization in Response to Lipid-Lowering Therapy: A Serial Optical Coherence Tomography Study

Frontiers in Cardiovascular Medicine, 2021
Objective: This study aimed to investigate the effect of smoking on morphological changes in non-culprit plaques in acute coronary syndrome (ACS) patients at 1 year after percutaneous coronary intervention (PCI), using optical coherence tomography (OCT ...
Xiling Zhang, Xiling Zhang, Xiang Peng, Xiang Peng, Lulu Li, Lulu Li, Huai Yu, Huai Yu, Bo Yu, Bo Yu   +9 more
doaj   +1 more source

Artificial Intelligence—A Good Assistant to Multi-Modality Imaging in Managing Acute Coronary Syndrome

Frontiers in Cardiovascular Medicine, 2022
Acute coronary syndrome is the leading cause of cardiac death and has a significant impact on patient prognosis. Early identification and proper management are key to ensuring better outcomes and have improved significantly with the development of ...
Ming-hao Liu, Ming-hao Liu, Chen Zhao, Chen Zhao, Shengfang Wang, Shengfang Wang, Haibo Jia, Haibo Jia, Bo Yu, Bo Yu   +9 more
doaj   +1 more source

Predicting Diagnostic Gene Biomarkers Associated With Immune Checkpoints, N6-Methyladenosine, and Ferroptosis in Patients With Acute Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2022
This study aimed to determine early diagnosis genes of acute myocardial infarction (AMI) and then validate their association with ferroptosis, immune checkpoints, and N6-methyladenosine (m6A), which may provide a potential method for the early diagnosis ...
Xiao Tong, Xiao Tong, Xinyi Zhao, Xinyi Zhao, Xuan Dang, Xuan Dang, Yan Kou, Yan Kou, Junjie Kou, Junjie Kou   +9 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

P2X4 receptor limits adverse cardiac remodeling following ischemia–reperfusion through regulation of autophagy in cardiac fibroblasts

Cell Communication and Signaling
Background Pathological ventricular remodeling is an adverse tissue response following acute myocardial infarction (AMI), characterized by an exaggerated fibrosis leading to tissue disorganization and chronic heart failure.
Ana Valeria Vinhais da Silva, Juliette Strella, Simon Chesseron, Arthur Aupart, Audrey Heraud-Meley, Elodie Miquelestorena-Standley, Marc Ohresser, Ludovica Congiu, Eric Boué-Grabot, Thierry Bourguignon, Sébastien Roger, Stephanie Chadet, Fabrice Ivanes   +12 more
doaj   +1 more source

NOX1 promotes myocardial fibrosis and cardiac dysfunction via activating the TLR2/NF-κB pathway in diabetic cardiomyopathy

Frontiers in Pharmacology, 2022
Diabetic cardiomyopathy (DCM) is a prevalent complication in patients with diabetes, resulting in high morbidity and mortality. However, the molecular mechanisms of diabetic cardiomyopathy have yet to be fully elucidated. In this study, we investigated a
Dandan Zhang, Dandan Zhang, Yilan Li, Yilan Li, Weijie Wang, Weijie Wang, Xueyan Lang, Xueyan Lang, Yanxiu Zhang, Yanxiu Zhang, Qianqian Zhao, Qianqian Zhao, Jingru Yan, Jingru Yan, Yao Zhang, Yao Zhang   +15 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Benefits of Simultaneous Pacing Left Anterior/Posterior Fascicular Areas Combined with Atrioventricular Node Ablation in a Persistent Atrial Fibrillation Patient with Heart Failure: A Case Report

Clinical Medicine Insights: Cardiology
A 50-year-old male had intermittent episodes of dyspnea for 7 days with persistent atrial fibrillation (AF) for 2 years. New York Heart Association (NYHA) functional class is IV status.
Bingchen Guo, Yanzong Liu, Jian Xu, Huimin Xian, Xiaohan Lin, Guoqing Du, Bo Yu, Shufeng Li, Wenjuan Du   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source