Lipid peroxidation is a nonparenchymal cell event with reperfusion after prolonged liver ischemia [PDF]
, 1990 A proposed mechanism for irreversible ischemic liver damage has been peroxidation of membrane phospholipids by free radicals. However, the hepatocyte is laden with enzymes which are antioxidants and, therefore, ought to be relatively resistant to ...
Makowka, L +3 more
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Lipids in Health and Disease, 2017 Background The mechanism of cholesteryl ester transfer protein (CETP) in lipid metabolism is still unclear. Furthermore, the relationship of CETP and atherosclerosis (AS) has been controversial. As pigs are a good model for both lipid and AS research, we
Tao Chen +5 more
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Ferroptosis: A Potential Target in Cardiovascular Disease
Frontiers in Cell and Developmental Biology, 2022 Ferroptosis is a new form of regulatory cell death characterized by iron-dependent and intracellular lipid peroxidation. Ferroptosis can be divided into two stages.
Yanlong Leng +9 more
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Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia [PDF]
, 2002 Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage.
Alvarez, Dalia +7 more
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Omentin-1 effects on mesenchymal stem cells: proliferation, apoptosis, and angiogenesis in vitro
Stem Cell Research & Therapy, 2017 Background Mesenchymal stem cells (MSCs) are emerging as an extremely promising therapeutic agent for tissue repair. However, limitations exist such as the low numbers of MSCs obtained from donors, and the poor survival and function of donor cells ...
Li Yin +6 more
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Plaque Erosion: A Distinctive Pathological Mechanism of Acute Coronary Syndrome
Frontiers in Cardiovascular Medicine, 2021 Plaque erosion (PE) is one of the most important pathological mechanisms underlying acute coronary syndrome (ACS). The incidence of PE is being increasingly recognized owing to the development and popularization of intracavitary imaging.
Xing Luo +17 more
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β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia [PDF]
, 2017 β-adrenergic receptor (β-AR) blockers may be administered during acute myocardial infarction (MI), as they reduce energy demand through negative chronotropic and inotropic effects and prevent ischemia-induced arrhythmogenesis. However, the direct effects
Domondon, Philip +7 more
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Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts [PDF]
, 2014 Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease.
A Beenken +54 more
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Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]
, 2004 Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo +4 more
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Frontiers in Cardiovascular Medicine, 2023 BackgroundAs a novel lipoprotein ratio, baseline low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LHR) is closely related to the clinical outcomes of acute coronary syndromes (ACS) after percutaneous coronary ...
Luping He +21 more
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