Results 41 to 50 of about 909,718 (306)

Benefits of Simultaneous Pacing Left Anterior/Posterior Fascicular Areas Combined with Atrioventricular Node Ablation in a Persistent Atrial Fibrillation Patient with Heart Failure: A Case Report

Clinical Medicine Insights: Cardiology
A 50-year-old male had intermittent episodes of dyspnea for 7 days with persistent atrial fibrillation (AF) for 2 years. New York Heart Association (NYHA) functional class is IV status.
Bingchen Guo, Yanzong Liu, Jian Xu, Huimin Xian, Xiaohan Lin, Guoqing Du, Bo Yu, Shufeng Li, Wenjuan Du   +8 more
doaj   +1 more source

A Concomitant Cancer Diagnosis Is Associated With Poor Cardiovascular Outcomes Among Acute Myocardial Infarction Patients

Frontiers in Cardiovascular Medicine, 2022
Background and AimsWith the increasing coexistence of cardiovascular disease and cancer in contemporary clinical practice, studies on the outcomes in acute myocardial infarction (AMI) patients with cancer has not been systematically investigated.
Xiang Peng, Xiang Peng, Zhuozhong Wang, Zhuozhong Wang, Muhua Cao, Muhua Cao, Yuqi Zheng, Yuqi Zheng, Ya'nan Tian, Ya'nan Tian, Li Yu, Li Yu, Wenjun Ni, Wenjun Ni, Shanjie Wang, Shanjie Wang, Zhifeng Qin, Zhifeng Qin, Suhong Zhao, Suhong Zhao, Jinwei Tian, Jinwei Tian, Bo Yu, Bo Yu   +23 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia

Cell Communication and Signaling
Background Small extracellular vesicles (sEVs) are critical mediators of cell communications and are influenced by cellular stress. This study investigates the role of P2X4 and P2X7 purinoreceptors in the biogenesis and release of sEVs from triple ...
Thomas Duret, Mohammed Elmallah, Audrey Heraud-Meley, Cloé Tessier, Ana Valeria Vinhais Da Silva, Stéphanie Chadet, Roxane Lemoine, Justine Gainche, Valérie Labas, Ana-Paula Teixeira-Gomes, Daniel Tomas, Vesna Cuplov, Lin-Hua Jiang, Lili Fan, Gang Yin, Christophe Baron, Sébastien Roger   +16 more
doaj   +1 more source

Glutathione treatment protects the rat liver against injury after warm ischemia and Kupffer cell activation [PDF]

, 2002
Background/Aim: The generation of reactive oxygen species by activated Kupffer cells (KC) may contribute to reperfusion injury of the liver during liver transplantation or resection.
Baron, A., Bilzer, M., Ebensberger, S., Gerbes, Alexander L., Schauer, R., Steib, C.   +5 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Focal Geometry and Characteristics of Erosion-Prone Coronary Plaques in vivo Angiography and Optical Coherence Tomography Study

Frontiers in Cardiovascular Medicine, 2021
Objective: This study compared focal geometry and characteristics of culprit plaque erosion (PE) vs. non-culprit plaques in ST-segment elevated myocardial infarction (STEMI) patients in whom optical coherence tomography (OCT) identified PE as the cause ...
Muhua Cao, Muhua Cao, Tianyu Wu, Tianyu Wu, Jiawei Zhao, Jiawei Zhao, Zhuo Du, Zhuo Du, Zhuozhong Wang, Zhuozhong Wang, Lulu Li, Lulu Li, Guo Wei, Guo Wei, Jinwei Tian, Jinwei Tian, Haibo Jia, Haibo Jia, Gary S. Mintz, Bo Yu, Bo Yu   +20 more
doaj   +1 more source

The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]

, 2015
Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B., Aydin, C., Berber, I., Birsen, O., Cevahir, N., Gumrukcu, G., Yenisey, C., Özban, Murat.   +7 more
core   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The Effect of Blood Pressure Variability on Coronary Atherosclerosis Plaques

Frontiers in Cardiovascular Medicine, 2022
Hypertension is one of the most important risk factors for coronary heart disease (CHD). The regulation of blood pressure plays a significant role in the development and prognosis of CHD.
Yue Liu, Yue Liu, Xing Luo, Xing Luo, Haibo Jia, Haibo Jia, Bo Yu, Bo Yu   +7 more
doaj   +1 more source