Results 41 to 50 of about 550,814 (265)

Loss of sirtuin SIRT1 promotes aggressiveness of colon adenocarcinoma by modulating voltage-gated sodium channel activity

Scientific Reports
Sirtuin 1 (SIRT1), a NAD⁺-dependent epigenetic regulator, has been reported as both tumour-promoting and tumour-suppressive in colorectal cancer, leaving its role unclear.
Hasna Aitouche-Djermouni, Oumnia Benouna, Adrien Pétereau, Lucile Poisson, Rémy Sindayigaya, Othman Iskander, Alizée Zadoroznyj, Charles Mureau, Thierry Lecomte, Ephrem Salamé, Driffa Moussata, Nicolas Michot, Nicolas Lamassiaude, Serge Guyetant, Urs Giger-Pabst, Osbaldo Lopez-Charcas, Sébastien Roger, Mehdi Ouaissi   +17 more
doaj   +1 more source

Focal Geometry and Characteristics of Erosion-Prone Coronary Plaques in vivo Angiography and Optical Coherence Tomography Study

Frontiers in Cardiovascular Medicine, 2021
Objective: This study compared focal geometry and characteristics of culprit plaque erosion (PE) vs. non-culprit plaques in ST-segment elevated myocardial infarction (STEMI) patients in whom optical coherence tomography (OCT) identified PE as the cause ...
Muhua Cao, Muhua Cao, Tianyu Wu, Tianyu Wu, Jiawei Zhao, Jiawei Zhao, Zhuo Du, Zhuo Du, Zhuozhong Wang, Zhuozhong Wang, Lulu Li, Lulu Li, Guo Wei, Guo Wei, Jinwei Tian, Jinwei Tian, Haibo Jia, Haibo Jia, Gary S. Mintz, Bo Yu, Bo Yu   +20 more
doaj   +1 more source

The wisdom in ISCHEMIA

Indian Heart Journal, 2020
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) study was published recently demonstrating that over a period of 3.3 years a routine invasive approach along with optimised medical therapy (OMT) was not superior to OMT alone in patients with stable coronary artery disease and at least moderate ...
Thomas, Boban, Hassan, Imad
openaire   +3 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia

Cell Communication and Signaling
Background Small extracellular vesicles (sEVs) are critical mediators of cell communications and are influenced by cellular stress. This study investigates the role of P2X4 and P2X7 purinoreceptors in the biogenesis and release of sEVs from triple ...
Thomas Duret, Mohammed Elmallah, Audrey Heraud-Meley, Cloé Tessier, Ana Valeria Vinhais Da Silva, Stéphanie Chadet, Roxane Lemoine, Justine Gainche, Valérie Labas, Ana-Paula Teixeira-Gomes, Daniel Tomas, Vesna Cuplov, Lin-Hua Jiang, Lili Fan, Gang Yin, Christophe Baron, Sébastien Roger   +16 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Higher serum phosphorus and calcium levels provide prognostic value in patients with acute myocardial infarction

Frontiers in Cardiovascular Medicine, 2022
BackgroundAlthough traditional cardiovascular risk factors are closely related to the poor prognosis of acute myocardial infarction (AMI) patients, there are few studies on the relationship of serum phosphorus and calcium with prognosis in AMI patients ...
Wei Cao, Wei Cao, Yilan Li, Yilan Li, Yao Wen, Shaohong Fang, Shaohong Fang, Bing Zhao, Bing Zhao, Xiaoyuan Zhang, Xiaoyuan Zhang, Yanxiu Zhang, Yanxiu Zhang, Xueyan Lang, Xueyan Lang, Bo Yu, Bo Yu, Yao Zhang, Yao Zhang   +18 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Inhibition of microRNA-183 expression resists human umbilical vascular endothelial cells injury by upregulating expression of IRS1

Drug Delivery, 2019
Our study aims to investigate the effect of microRNA-183 (miR-183) on human umbilical vascular endothelial cells (HUVECs) injury by targeting IRS1. HUVECs injury was induced by oxidized low-density lipoprotein (ox-LDL).
Yingying Zhang, Yefei Zhan, Dandan Liu, Bo Yu   +3 more
doaj   +1 more source