Results 41 to 50 of about 886,706 (266)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz +14 morewiley +1 more sourceGenome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke [PDF]
, 2012 Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of ...Furie, K., Seedorf, Udo, Cathie L M Sudlow, Spencer, C.C.A., Woo, D., Müller-Myhsok, B., Jackson, C. A., Sawcer, SJ, Markus, Hugh S, Lindgren, Arne,, Segal, H, Viswanathan, Ananth C., Syme, P. D., Valerie Valant, Rautanen, A, Matthew Traylor, Gray, E, Sarah Edkins, Attia, J., Palmer, C., Rothwell, Peter M., Juan P Casas, Levi, Chris, Worrall, Bradford B, Levi, C., Jankowski, J., Peltonen, L, Palmer, Colin N. A., Sawcer, S., Edkins, Sarah, Delavaran, Hossein,, Kissela, Brett, Pankaj Sharma, WTCCC2, Sharma, P, Goel, A, Gray, E., Joanna Pera, Palmer, CN, Boonen, S., Worrall, BB, Dorota Wloch-Kopec, Cordelia Langford, Helgadottir, A, Steve Bevan, Su, Zhan, Rothwell, Peter M, Sudlow, Cathie LM, Wellcome Trust Case Control Consortium 2 (WTCCC2) (), Bradford B Worrall, Viswanathan, A.C., Hossein Delavaran, Valant, V., Nalls, Michael A., Stefansson, K, Donnelly, P, Palmer, Colin NA, Worrall, B., Wloch-Kopec, D., Martin Farrall, Elvira Bramon, Lindgren, Arne, Valant, V, Kittner, Steven J., Corvin, A., Syme, PD, Meisinger, Christa, Schanz, R., Delavaran, H, Goel, Anuj, Audrey Duncanson, Unnur Thorsteinsdottir, Syme, P.D., Bramon, E, Stephen J Sawcer, Pirinen, Matti, Burgess, A., Kissela, B., Cheng, Y., Helen Segal, Cheng, YC, Meschia, JF, Edkins, S., Levi, C, Parati, E. A., Rainer Malik, Meschia, J., Trembath, R., Cortellini, L., Burgess, AI, Trembath, RC, ?, ?, Langford, C, Boncoraglio, G. B., Bevan, S, Poole, D, International Store Genetics Consortium, Burgess, A.I., Spencer, Chris CA, Spencer, Chris, Nalls, M.A., Bellenguez, C., Matthew Walters, Traylor, M, Boncoraglio, G.B., Attia, John, Freeman, Colin, Jackson, Caroline; id_orcid, Lemmens, Robin, Spencer, Chris C. A., Sudlow, Cathie L M, Ross-Adams, H., Thijs, V, Gray, Emma, Hugh S Markus, Dichgans, M, Nicholas W Wood, Wellcome Trust Case Control Consortium 2 (WTCCC2), Brown, MA, Norrving, Bo,, Wood, N.W., Brown, M., Burgess, Annette I, International Stroke Genetics Consortium (Meisinger, C.), Emma Gray, Mitchell, BD, Colin Freeman, Giorgio B Boncoraglio, Norrving, B., Franzosi, MG, James, T., Slark, Julia, Mitchell, B., Murphy, Lee, Wood, N. W., Goel, A., Julia Slark, Seedorf, U, Boonen, S, Udo Seedorf, Boonen, Steven, Sharma, Pankaj, Deborah Poole, Rothwell, PM, Casas, J., Su, Z., Edkins, S, Cheng, Yu-Ching, Colin N A Palmer, Franzosi, M., Lund University., Lee Murphy, Elizabeth Holliday, Wood, Nicholas W, Rothwell, P., Viswanathan, Ananth C, Norrving, Bo, Anuj Goel, Tom James, Casas, J. P., Gretarsdottir, S., Sarah Hunt, Sudlow, C.L.M., Gschwendtner, A., Bevan, Steve, Deloukas, P., Müller-Myhsok, Bertram, Janusz Jankowski, Yu-Ching Cheng, Macleod, M.J., Dronov, S, Slowik, A, Walters, Matthew, Meschia, James F, Pera, J, Plomin, R, Spencer, CCA, Casas, JP, Brown, Matthew A, Mathew, Christopher G., Peltonen L, Holliday, E., Slowik, A., Bramon, Elvira, Plomin, Robert, Cheng, Y. C., Band, G., Thorsteinsdottir, U, Helen Ross-Adams, Sudlow, C., Strange, A, Band, Gavin, Markus, H.S., Wellcome Trust Control Consortium, Rautanen, A., Nalls, Michael A, Worrall, B. B., Blackwell, J. M., Casas, Juan P., Deloukas, Panos, Macleod, MJ, Thijs, Vincent, Spencer, C., Ananth C Viswanathan, Traylor, M., Duncanson, A., Poole, Deborah, Bramon, E., Wloch-Kopec, D, Spencer, CC, Holliday, E, Macleod, Mary Joan, Band, G, Palmer, CNA, Bevan, S., Viswanathan, AC, Poole, D., Schanz, R, Macleod, M., Palmer, C. N. A., Meisinger, C., Furie, Karen, Viswanathan, A., Woo, Daniel, Delavaran, H., Dronov, S., International Stroke Genetics Consortium (ISGC), Anna Helgadottir, Kissela, B, Corvin, Aiden, Sudlow, CL, Casas, J.P., Annette I Burgess, Markus, H. S., Helgadottir, Anna, Panos Deloukas, Jackson, C., Jackson, Caroline A., Mitchell, Braxton D., Walters, M., Bertram Müller-Myhsok, Franzosi, M-G, Bo, N, Donnelly, P., Burgess, A. I., Andreas Gschwendtner, Deloukas, P, Rosand, Jonathan, Gavin Band, Langford, C., Vincent Thijs, Sawcer, Stephen J, Cortellini, L, Delavaran, Hossein, Solveig Gretarsdottir, Peltonen, L., Burgess, Annette I., Wood, N., Lemmens, R, Mueller-Myhsok, Bertram, Parati, E.A., Franzosi, M. G., Farrall, M, Segal, H., Corvin, A, Kittner, Steven J, Mathew, Christopher G.; id_orcid, Sudlow, Catherine; id_orcid, Valant, Valerie, Hunt, S., Leena Peltonen, Palmer, C.N.A., Franzosi, Maria-Grazia, Mary Joan Macleod, Segal, Helen, Wood, Nicholas W., Arne Lindgren, Hunt, S, Bellenguez, Céline, Daniel Woo, Kari Stefansson, Rothwell, P.M., Furie, K, Matti Pirinen, Murphy, L, Céline Bellenguez, Dichgans, M., Boncoraglio, Giorgio B, Peter M Rothwell, Blackwell, Jenefer M., Christopher G Mathew, Duncanson, A, Jonathan Rosand, Trembath, Richard C, Sudlow, CLM, Chris C A Spencer, Pera, Joanna, Nalls, M. A., Meisinger, C, Rosand, J., James F Meschia, Palmer, Colin N A, Gudmar Thorleifsson, Wloch-Kopec, Dorota, Robin Lemmens, Agnieszka Slowik, Markus, H., Lemmens, R., Slark, J., Kittner, S. J., Boncoraglio, Giorgio B., Viswanathan, A. C., Cortellini, Lynelle, Peltonen, Leena, Sawcer, Stephen J., Seedorf, U., Parati, E., Peter Donnelly, Serge Dronov, Worrall, Bradford B., Mitchell, Braxton D, Malik, R., Boncoraglio, GB, Strange, Amy, Lindgren, A, Caroline A Jackson, Freeman, C., Thorsteinsdottir, Unnur, Brown, M. A., Jenefer M Blackwell, Bo, N., Wood, NW, Langford, Cordelia, Ross-Adams, Helen, Parati, Eugenio A, Hunt, Sarah, Stefansson, K., Blackwell, Jenefer M, Boncoraglio, G., Markus, HS, Rosand, J, Jackson, Caroline A, Norrving, B, Dronov, Serge, Anna Rautanen, Farrall, M., Jackson, CA, Sudlow, C. L. M., Thorleifsson, G, Malik, R, Slowik, Agnieszka, Lindgren, A., Amy Strange, Mathew, C., Renata Schanz, James, Tom, Ross-Adams, H, Matthew A Brown, Farrall, Martin, Syme, Paul D, Schanz, Renata, Mathew, CG, Helgadottir, A., Donnelly, Peter, Brett Kissela, Stefansson, Kari, Pirinen, M., Sharma, P., Mathew, Christopher G, Martin Dichgans, Nalls, M., Zhan Su, Parati, EA, Attia, J, Gretarsdottir, Solveig, Trembath, Richard C., Kittner, S., Pirinen, M, Nalls, MA, Cheng, Y-C, Müller-Myhsok, B, Strange, A., Blackwell, JM, Slark, J, Sudlow, Cathie L. M., Thorsteinsdottir, U., Kittner, S.J., Mathew, C. G., Su, Z, Plomin, R., Kittner, SJ, Spencer, Chris C A, Jackson, C.A., Worrall, B.B., Casas, Juan P, Gschwendtner, Andreas, Dichgans, Martin, Blackwell, J., Thorleifsson, G., Michael A Nalls, Gschwendtner, A, Macleod, M. J., Aiden Corvin, Eugenio A Parati, Murphy, L., Rautanen, Anna, Thorleifsson, Gudmar, Jankowski, Janusz, Freeman, C, Syme, P., Sawcer, S.J., Meschia, J. F., Steven J Kittner, John Attia, Brown, Matthew A., Rothwell, P. M., Syme, Paul D., ISGC, Parati, Eugenio A., Markus HS, Robert Plomin, James, T, Walters, M, Mitchell, B. D., Bo Norrving, Trembath, R. C., Meschia, J.F., Pera, J., Duncanson, Audrey, Mitchell, B.D., Woo, D, Spencer, C. C. A., Markus, Hugh S., Jankowski, J, Blackwell, J.M., Chris Levi, Thijs, V., Gretarsdottir, S, Christa Meisinger, Richard C Trembath, Holliday, Elizabeth, Steven Boonen, Mathew, C.G., Murphy, Lee; id_orcid, Bellenguez, C, Meschia, James F., Malik, Rainer, Braxton D Mitchell, Sawcer, S. J., Traylor, Matthew, Karen Furie, Trembath, R.C., Lynelle Cortellini, Maria-Grazia Franzosi, Paul D Syme, Palmer, Colin N. A.; id_orcid +455 morecore +2 more sourcesBambi/Akt/Tlr4 axis protects against atherosclerosis by maintaining lipid metabolism homeostasis in macrophages
Lipids in Health and DiseaseBackground and aims Atherosclerosis is a chronic inflammatory disease driven by dysregulated lipid metabolism and macrophage dysfunction. However, the role of Bmp and activin membrane-binding inhibitor (Bambi), a pseudoreceptor that antagonizes Tgfβ ...Xiaochang Chen, Siyu Tan, Siting Li, Peihong Su, Hua Guan, Aoqi Xiang, Lusha Zhang, Haoping Wang, Qi Yu +8 moredoaj +1 more sourceDeterminants of Outcome Variability in Ischemic Stroke: A Focus on Routinely Collected Biomarkers
AntioxidantsIschemic stroke remains a leading cause of mortality and disability, with proinflammatory, metabolic, and oxidative stress-related factors contributing to outcome variability. We conducted a retrospective cross-sectional study of 124 consecutive patients Alexandru Gerdanovics, Sorana D. Bolboacă, Ioana Cristina Stănescu, Camelia Manuela Mîrza, Gabriela Bombonica Dogaru, Cristina Ariadna Nicula, Paul Mihai Boarescu, Cezara-Andreea Gerdanovics, Adriana-Elena Bulboacă +8 moredoaj +1 more sourceChronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...Anu Singh, Aroonima Misra, Sufian Zaheerwiley +1 more sourceAdditional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial [PDF]
, 2006 <p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant demonstrated to reduce disability from ischemic stroke. We conducted analyses on additional end points and sensitivity analyses to confirm our findings.Lees, K.R., Diener, H.-C., Shuaib, A., Zivin, J.A., Davis, S.M., Wasiewski, W., Lyden, P., Emeribe, U., Ashwood, T., Hardemark, H.G., Davalos, A., Grotta, J. +11 morecore +1 more source
