Results 81 to 90 of about 163,159 (308)
HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury
Advanced Science, EarlyView.Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou +7 more
wiley +1 more source
Analysis of atherosclerotic plaque distribution in the carotid artery
Clinical Cardiology, Volume 45, Issue 12, Page 1272-1276, December 2022., 2022 Abstract Background The present study was designed to investigate the hypothesis that the outer wall at the carotid bifurcation is the most common area of atherosclerotic plaque deposition due to the low shear stress. Hypothesis We hypothesized that the most common site of arteriosclerosis in carotid arteries is different in the early and late stages ...
Shin‐Seok Yang +2 more
wiley +1 more source
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]
Neuroscience Research 47(2): 245-253 (2003), 2007 Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury.
arxiv
Advanced Science, EarlyView.The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du +9 more
wiley +1 more source
Clinical Cardiology, Volume 45, Issue 12, Page 1264-1271, December 2022., 2022 Abstract Background Severe atherosclerosis of the ascending aorta (SAA) in patients undergoing surgical revascularization by coronary artery bypass grafting (CABG) is becoming an increasing problem as more elderly patients are diagnosed with coronary artery disease.
Rakan I. Nazer, Ali M. Albarrati
wiley +1 more source
The role of transient ischemic attacks in the occurrence of cognitive impairment [PDF]
Саратовский научно-медицинский журнал, 2016 The information about cognitive impairment of patient, suffered from transient ischemic attack (TIA) is summarized on the base of Russian and foreign literature.
Maleina A.U. +2 more
doaj
Therapeutics and Clinical Risk Management, 2022 Sergiu Florin Arnăutu,1,2,* Vlad Ioan Morariu,3,4,* Diana Aurora Arnăutu,3,4 Mirela Cleopatra Tomescu,3,4 Traian Flavius Dan,1,2 Cătălin Dragos Jianu1,2 1Neurology Department, Victor Babeș University of Medicine and ...
Arnăutu SF +5 more
doaj
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils [PDF]
Brain Research 927(2): 212-215 (2002), 2007 Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils.
arxiv
Circulation, 2017 Background: The association of genetic polymorphisms and clopidogrel efficacy in patients with ischemic stroke or transient ischemic attack (TIA) remains controversial.
Yuesong Pan +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li +21 more
wiley +1 more source