Results 101 to 110 of about 1,151,873 (316)

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

Advanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
wiley   +1 more source

RANOLAZINE IN ISCHEMIC HEART DISEASE

Рациональная фармакотерапия в кардиологии, 2015
Study results of a new anti-anginal drug (an inhibitor of sodium channels — ranolazine) are presented. Indications, contraindications, major clinical trials of the drug in patients with ischemic heart disease are considered.
V. P. Lupanov
doaj   +1 more source

Ischemic Heart Disease Mortality and Long-Term Exposure to Source-Related Components of U.S. Fine Particle Air Pollution

Environmental Health Perspectives, 2015
Background: Fine particulate matter (PM2.5) air pollution exposure has been identified as a global health threat. However, the types and sources of particles most responsible are not yet known. Objectives: We sought to identify the causal characteristics
D. Thurston, G. Thurston, R. Burnett, M. Turner, Yuanli Shi, D. Krewski, R. Lall, Kazuhiko Ito, M. Jerrett, S. Gapstur, W. Ryan Diver, C. Arden, Pope Iii, Thurston Gd, Burnett Rt, Turner Mc, Shi Y, Krewski D, Lall R, Ito K, Jerrett M, Gapstur Sm   +21 more
semanticscholar   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, EarlyView.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

ASSESSMENT OF CONCOMITANT PATHOLOGY AND OUTCOMES OF CHRONIC HEART FAILURE OF VARIOUS ETIOLOGIES IN PATIENTS OF THE SOUTHERN REGION OF INDIA

Байкальский медицинский журнал
Relevance. Сhronic heart failure is a widespread pathology due to the high incidence of hypertension and coronary artery disease. Several million new cases of heart failure are reported in India every year.
Andrey S. Ankudinov, Oman Soman Suman, Konstantin S. Tolkachev   +2 more
doaj   +1 more source

Ischemic Stroke in Children and Young Adults With Congenital Heart Disease

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Patients with congenital heart disease (CHD) may be at increased risk of ischemic stroke due to residual shunts, arrhythmias, and other cardiovascular abnormalities.
Z. Mandalenakis, A. Rosengren, G. Lappas, P. Eriksson, P. Hansson, M. Dellborg   +5 more
semanticscholar   +1 more source

Habitual coffee consumption and risk of type 2 diabetes, ischemic heart disease, depression and Alzheimer’s disease: a Mendelian randomization study [PDF]

, 2016
Man Ki Kwok, GM Leung, C. Mary Schooling
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Stored iron and ischemic heart disease. Empirical support for a new paradigm. [PDF]

, 1992
J. L. Sullivan
openalex   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source