Results 211 to 220 of about 25,118 (249)

Clinical Relevance of Ischemic Preconditioning

Scandinavian Cardiovascular Journal, 2001
The mechanisms of ischemic cell death and reperfusion injury in the myocardium and the ways to limit these have been under extensive research for decades. The discovery of the phenomenon of ischemic preconditioning, i.e. endogenous protection against ischemia-reperfusion injury obtained by one or more brief preceding episodes of ischemia, really ...
K, Ylitalo, K, Peuhkurinen
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Ischemic preconditioning—an unfulfilled promise

Cardiovascular Revascularization Medicine, 2015
Myocardial reperfusion injury has been identified as a key determinant of myocardial infarct size in patients undergoing percutaneous or surgical interventions. Although the molecular mechanisms underpinning reperfusion injury have been elucidated, attempts at translating this understanding into clinical benefit for patients undergoing cardiac ...
Williams, Timothy M., Waksman, Ron, De Silva, Kalpa, Jacques, Adam, Mahmoudi, Michael   +4 more
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Ischemic preconditioning: Exploring the paradox

Progress in Cardiovascular Diseases, 1998
Brief transient episodes of nonlethal myocardial ischemia protect or "precondition" the heart and render the myocardium resistant to a subsequent more sustained ischemic insult. The hallmark of this phenomenon--documented in virtually all species and experimental models evaluated to date in countless laboratories worldwide--is the profound reduction in
K, Przyklenk, R A, Kloner
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Role of STAT3 in Ischemic Preconditioning

Journal of Molecular and Cellular Cardiology, 2001
We recently demonstrated that ischemic preconditioning (IPC) induced by cyclic episodes of short durations of ischemia and reperfusion potentiates a signal transduction cascade involving protein tyrosine kinases and MAP kinases. A rapid activation of janus kinase (JAK) and several signal transducers and activators of the transcription (STATs) including
R, Hattori, N, Maulik, H, Otani, L, Zhu, G, Cordis, R M, Engelman, M A, Siddiqui, D K, Das   +7 more
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Signaling pathways in ischemic preconditioning

Heart Failure Reviews, 2007
Ischemic preconditioning renders the heart resistant to infarction from ischemia/reperfusion. Over the past two decades a great deal has been learned about preconditioning's mechanism. Adenosine, bradykinin, and opioids act in parallel to trigger the preconditioned state and do so by activating PKC.
James M, Downey, Amanda M, Davis, Michael V, Cohen   +2 more
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SAPKs regulation of ischemic preconditioning

American Journal of Physiology-Heart and Circulatory Physiology, 2000
The role of stress-activated protein kinases (SAPKs), c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase, in preconditioning (PC) was examined with the use of isolated rat hearts subjected to four cyclic episodes of 5-min ischemia and 10-min reperfusion followed by 30-min ischemia and 2-h reperfusion (I/R). A group of hearts
M, Sato, G A, Cordis, N, Maulik, D K, Das   +3 more
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Ischemic Preconditioning

Journal of Thrombosis and Thrombolysis, 2000
Atsushi Nakano, Michael V Cohen, James M Downey   +2 more
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On the relevance of ischemic preconditioning in humans

Basic Research in Cardiology, 1997
In conclusion, existing data in animals and in man give us no reason to doubt that ischemic preconditioning can and will occur in patients. The clinical implication of endogenous protection will be difficult to determine because of large variability in the preceding pathological conditions and our inability to determine infarct size and its major ...
P D, Verdouw, M A, van den Doel, S, de Zeeuw, D J, Duncker   +3 more
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Ischemic Preconditioning, Cardioplegia or Both?

Journal of Molecular and Cellular Cardiology, 1994
With the continuing search for superior methods of myocardial protection, we compared the protective efficacy of ischemic preconditioning with that of St Thomas' cardioplegia, alone and in combination, against vascular and myocyte injury during ischemia and reperfusion.
K G, Kolocassides, M, Galiñanes, D J, Hearse   +2 more
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Signal Transduction in Ischemic Preconditioning

1997
Ischemic preconditioning is a phenomenon in which exposure of the heart to a brief period of ischemia causes it to quickly adapt itself to become resistant to infarction from a subsequent ischemic insult. The mechanism is not fully understood but, at least in the rabbit, it is known to be triggered by occupation of adenosine receptors, opioid receptors,
J M, Downey, M V, Cohen
openaire   +3 more sources