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Proceedings of the 2015 XSEDE Conference on Scientific Advancements Enabled by Enhanced Cyberinfrastructure - XSEDE '15, 2015
In this paper we present ISLET; the Isolated, Scalable, & Lightweight Environment for Training. ISLET overcomes many of the distribution, scaling and security challenges of providing mass training to students requiring an interactive GNU/Linux command-line environment.
Jonathan Schipp +2 more
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In this paper we present ISLET; the Isolated, Scalable, & Lightweight Environment for Training. ISLET overcomes many of the distribution, scaling and security challenges of providing mass training to students requiring an interactive GNU/Linux command-line environment.
Jonathan Schipp +2 more
openaire +1 more source
Clinical islet transplantation
Current Diabetes Reports, 2003Type 1 diabetes affects over 1 million persons in the United States, with over 30,000 new cases diagnosed annually. Transplantation of new insulin-producing b cells, in the form of the whole pancreas or isolated islets, has been shown to ameliorate the disease by eliminating the need for exogenous insulin and normalizing glycosylated hemoglobin levels.
Dixon B, Kaufman, William L, Lowe
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Ultrastructural Pathology, 1991
A case of islet cell tumor occurring in a patient with the multiple endocrine neoplasia type I syndrome is reported. Immunostaining for insulin was strongly positive in the tumor cells. Numerous dense-core granules of endocrine caliber were identified ultrastructurally.
B, Fitzpatrick, N G, Ordoñez, B, Mackay
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A case of islet cell tumor occurring in a patient with the multiple endocrine neoplasia type I syndrome is reported. Immunostaining for insulin was strongly positive in the tumor cells. Numerous dense-core granules of endocrine caliber were identified ultrastructurally.
B, Fitzpatrick, N G, Ordoñez, B, Mackay
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Current Opinion in Organ Transplantation, 2008
The transplantation of human islets has come a long way since the first diabetic person became insulin independent in 1989. The advent of a steroid-free immunosuppressive protocol in 2000 resulted in most recipients becoming insulin independent and remaining so for a year. However, beta-cell function declines thereafter. Strategies to enhance the islet
Vijayaganapathy, Vaithilingam +2 more
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The transplantation of human islets has come a long way since the first diabetic person became insulin independent in 1989. The advent of a steroid-free immunosuppressive protocol in 2000 resulted in most recipients becoming insulin independent and remaining so for a year. However, beta-cell function declines thereafter. Strategies to enhance the islet
Vijayaganapathy, Vaithilingam +2 more
openaire +2 more sources
Seminars in Pediatric Surgery, 2014
Islet transplantation has become a promising treatment for selected patients with type 1 diabetes. Here we provide an overview of the procedure including its history, the process of donor selection, and the techniques and procedures involved in a successful transplant.
Michael, McCall, A M James, Shapiro
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Islet transplantation has become a promising treatment for selected patients with type 1 diabetes. Here we provide an overview of the procedure including its history, the process of donor selection, and the techniques and procedures involved in a successful transplant.
Michael, McCall, A M James, Shapiro
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2010
Over the last years, there has been great success in driving stem cells toward insulin-expressing cells. However, the protocols developed to date have some limitations, such as low reliability and low insulin production. The most successful protocols used for generation of insulin-producing cells from stem cells mimic in vitro pancreatic organogenesis ...
Anabel, Rojas +5 more
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Over the last years, there has been great success in driving stem cells toward insulin-expressing cells. However, the protocols developed to date have some limitations, such as low reliability and low insulin production. The most successful protocols used for generation of insulin-producing cells from stem cells mimic in vitro pancreatic organogenesis ...
Anabel, Rojas +5 more
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Islet Cryopreservation Protocols
Annals of the New York Academy of Sciences, 1999ABSTRACT: Low temperature banking of islets has facilitated ongoing clinical trials, allowing for the collection and long‐term storage of islets during which viability and sterility assessment can be carried out. Islets from most species of animals have been cryopreserved using various freeze‐thaw protocols; however, the best to date is slow cooling ...
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2016
The overarching success of islet transplantation relies on the success in the laboratory to isolate the islets. This chapter focuses on the processes of human islet cell isolation and the ways to optimally provide islet cells for transplantation. The major improvements in regards to the choice of enzyme type, way the digested pancreas tissue is handled
Wayne J, Hawthorne +2 more
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The overarching success of islet transplantation relies on the success in the laboratory to isolate the islets. This chapter focuses on the processes of human islet cell isolation and the ways to optimally provide islet cells for transplantation. The major improvements in regards to the choice of enzyme type, way the digested pancreas tissue is handled
Wayne J, Hawthorne +2 more
openaire +2 more sources
La Presse Médicale, 2012
Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies on the detection of insulitis, of islet cell antibodies, of activated β-cell-specific T lymphocytes and on the association of T1D with a restricted set of class II major ...
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Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies on the detection of insulitis, of islet cell antibodies, of activated β-cell-specific T lymphocytes and on the association of T1D with a restricted set of class II major ...
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Pflügers Archiv, 2000
Pancreatic islets are neuroendocrine organs that control blood glucose homeostasis. The precise interplay of a heterogeneous group of cell populations (beta, alpha, delta and PP cells) results in the fine-tuned release of counterbalanced hormones (insulin, glucagon, somatostatin and pancreatic polypeptide respectively).
B, Soria +13 more
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Pancreatic islets are neuroendocrine organs that control blood glucose homeostasis. The precise interplay of a heterogeneous group of cell populations (beta, alpha, delta and PP cells) results in the fine-tuned release of counterbalanced hormones (insulin, glucagon, somatostatin and pancreatic polypeptide respectively).
B, Soria +13 more
openaire +2 more sources