Results 271 to 280 of about 121,748 (297)
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Pig islets for clinical islet xenotransplantation
Current Opinion in Nephrology and Hypertension, 2009Allogeneic islet transplantation faces difficulties because organ shortage is recurrent; several pancreas donors are often needed to treat one diabetic recipient; and the intrahepatic site of islet implantation may not be the most appropriate one. Another source of insulin-producing cells, therefore, would be of major interest, and pigs represent a ...
Pierre Gianello, Denis Dufrane
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Journal of Hepato-Biliary-Pancreatic Surgery, 2000
Recently, significant advances have been made in the number and purity of islets that can be retrieved from the human pancreas, thus enabling several centers to initiate or resume clinical trials of islet transplantation in type I diabetic patients. Although the success rate of islet transplantation is lower than that of pancreas transplantation in ...
Kazutomo Inoue, Masaaki Miyamoto
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Recently, significant advances have been made in the number and purity of islets that can be retrieved from the human pancreas, thus enabling several centers to initiate or resume clinical trials of islet transplantation in type I diabetic patients. Although the success rate of islet transplantation is lower than that of pancreas transplantation in ...
Kazutomo Inoue, Masaaki Miyamoto
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Current Diabetes Reports, 2016
Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells.
Daniela Liberati, Vito Lampasona
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Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells.
Daniela Liberati, Vito Lampasona
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Islet Yield Remains a Problem in Islet Autotransplantation
Archives of Surgery, 2002For patients with chronic pancreatitis whose pain is inadequately controlled with opiate analgesia, surgical resection offers a good chance of symptomatic relief. However, the inevitable sequela is type 1 diabetes mellitus and its attendant long-term complications.
Morrison, C. +3 more
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Porcine Islets as an Alternative to Human Islets for Transplantation [PDF]
Journal of Investigative Medicine, 2001 My discussion will focus on the use of porcine islets as an alternative to human islets for transplantation. In my opinion, allotransplantation (human-to-human) will remain the gold standard. I hope to convince you by the end of this talk, however, that in the future, there may be a need to consider alternative sources of organs.
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Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets [PDF]
Diabetes, 1993 This study investigated the effect of glucose on islet amyloid polypeptide secretion, content, and mRNA synthesis of human pancreatic islets. The release of islet amyloid polypeptide from fresh isolated islets in response to glucose was parallel to that of insulin.
Y Sarri +4 more
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Cyclosporine and Islet Mass—Implications for Islet Transplantation
Journal of Surgical Research, 1993Cyclosporine (CsA) is an inhibitor of ornithine decarboxylase (ODC), a key enzymatic step in cell proliferation. The purpose of this study was to determine the effect of CsA on islet cell mass. Partial obstruction (PDO) of the hamster pancreas is an established model of islet cell differentiation and proliferation in which regeneration is mediated by ...
L. Hornby +2 more
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Superiority of Fresh Islets Compared With Cultured Islets
Transplantation Proceedings, 2009It has recently been reported that the outcomes of islet transplantation with short periods of culture are comparable with those of freshly isolated islets. To clarify the influence of culture, fresh islets were compared with cultured islets in terms of quality.The quality of freshly isolated islets was compared with that of cultured islets with CMRL ...
Masafumi Goto +7 more
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Journal of Materials Chemistry B, 2018
Review of emerging advances and persisting challenges in the engineering and translation of islet encapsulation technologies.
Alexander Ulrich Ernst +2 more
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Review of emerging advances and persisting challenges in the engineering and translation of islet encapsulation technologies.
Alexander Ulrich Ernst +2 more
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