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Transplantation Proceedings, 2006
One of the main barriers to widespread application of islet transplantation is the limited availability of human pancreatic islets. The reduction of graft islet mass for transplantation to a recipient is one of the strategies in islet transplantation. However, transplantation of only a small number of islets may result in primary nonfunction.
K. Nakada +5 more
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One of the main barriers to widespread application of islet transplantation is the limited availability of human pancreatic islets. The reduction of graft islet mass for transplantation to a recipient is one of the strategies in islet transplantation. However, transplantation of only a small number of islets may result in primary nonfunction.
K. Nakada +5 more
openaire +3 more sources
Electrophysiology of Islet Cells
2010Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical activity. Changes of the membrane potential (V(m)) are regulated by metabolism-dependent alterations in ion channel activity. This coupling is best explored in beta-cells. The effect of glucose is directly linked to mitochondrial metabolism as the ATP/ADP ratio determines ...
Peter Krippeit-Drews +2 more
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Current Molecular Medicine, 2006
Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The islets, that are only 1% of the total
Bertuzzi F +2 more
openaire +4 more sources
Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The islets, that are only 1% of the total
Bertuzzi F +2 more
openaire +4 more sources
Diabetes & Metabolism, 2006
The Edmonton trials have brought about a marked improvement in the short-term rate of success of islet transplantation with rates of insulin-independence of 80% at 1-year being reported by several institutions worldwide. Unfortunately, this rate consistently decreases to 10-15% by 5 years post-transplantation.
Berney, Thierry, Toso, Christian
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The Edmonton trials have brought about a marked improvement in the short-term rate of success of islet transplantation with rates of insulin-independence of 80% at 1-year being reported by several institutions worldwide. Unfortunately, this rate consistently decreases to 10-15% by 5 years post-transplantation.
Berney, Thierry, Toso, Christian
openaire +4 more sources
Pancreas and islet transplantation
The Japanese Journal of Surgery, 1977AbstractConsiderable evidence supports the hypothesis that the microangiopathic lesions of diabetes are secondary to disordered metabolism. This hypothesis underlies the rationale for whole pancreas and islet transplantation. Whole pancreas transplantation has had limited clinical success—only 1 of 47 recipients reported to the ACS/NIH Transplant ...
David E.R. Sutherland +2 more
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Calcium Signaling in the Islets
2010Easy access to rodent islets and insulinoma cells and the ease of measuring Ca(2+) by fluorescent indicators have resulted in an overflow of data that have clarified minute details of Ca(2+) signaling in the rodent islets. Our understanding of the mechanisms and the roles of Ca(2+) signaling in the human islets, under physiological conditions, has been
M. Shahidul. Islam, M. Shahidul. Islam
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Connecting islet development and developing useful islets
Trends in Endocrinology & Metabolism, 2002The growth of pancreatic endocrine cells occurs early in the developing embryo. The signals that initiate the development are not defined, but several secreted proteins participate directly or indirectly in the differentiation of epithelial cells into hormone-producing cells.
Diane M. Simeone, Charles F. Burant
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Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets
Trends in Molecular Medicine, 2002The aim of encapsulation of pancreatic islets is to transplant in the absence of immunosuppression. It is based on the principle that transplanted tissue is protected from the host immune system by an artificial membrane. Encapsulation allows for application of insulin-secreting cells of animal or other surrogate sources, to overcome human islet ...
DE VOS P, MARCHETTI, PIERO
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The Comparative Anatomy of Islets
2010In the past 20 years, numerous publications on a variety of mammalian and non-mammalian species have appeared in the literature to supplement the excellent comparative work performed in the 70s and 80s by the Falkmer, Epple, and Youson groups. What emerges is that islets are much more complex than once thought and show a lot of similarities in rodents ...
openaire +3 more sources