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Islet Amyloid Polypeptide [PDF]

Encyclopedia of Molecular Pharmacology, 2021

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Cysteine-Derived Chiral Carbon Quantum Dots: A Fibrinolytic Activity Regulator for Plasmin to Target the Human Islet Amyloid Polypeptide for Type 2 Diabetes Mellitus.

ACS Applied Materials and Interfaces, 2023
The fibrillization and deposition of the human islet amyloid polypeptide (hIAPP) are the pathological hallmark of type 2 diabetes mellitus (T2DM), and these insoluble fibrotic depositions of hIAPP are considered to strongly affect insulin secretion by ...
Yongzhen Yang, Qin Wang, Gongjian Li, Wenjing Guo, Zuojun Yang, Hao Liu, Xiao-chen Deng   +6 more
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Islet Amyloid Polypeptide Triggers α-synuclein Pathology in Parkinson's Disease.

Progress in neurobiology, 2023
Pathologic aggregation and prion-like propagation of α-synuclein (α-syn) are the hallmarks of Parkinson's disease (PD). Emerging evidence shows that type 2 diabetes mellitus (T2DM) is a risk factor for PD.
Lanxia Meng, Yiming Li, Congcong Liu, Guoxin Zhang, Jiehui Chen, Min Xiong, Lina Pan, Xingyu Zhang, Guiqin Chen, Jing Xiong, Chaoyang Liu, Ximing Xu, Lihong Bu, Zhaohui Zhang, Zhentao Zhang   +14 more
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Exploration of Isoquinoline Alkaloids as Potential Inhibitors against Human Islet Amyloid Polypeptide.

ACS Chemical Neuroscience, 2022
Type-2 diabetes mellitus (T2DM) is one of the most concerning public health problems because of its high incidence, multiple complications, and difficult treatment.
Yanan Wang, Ting Zheng, Y. Huo, W. Du
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Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

Physiological Reviews, 2011
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both locally in the islets, where it inhibits insulin and glucagon secretion, and at distant targets.
Per, Westermark, Arne, Andersson, Gunilla T, Westermark   +2 more
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Islet Amyloid, Islet-Amyloid Polypeptide, and Diabetes Mellitus

New England Journal of Medicine, 1989
Islet-amyloid deposits, which are a common feature of Type II diabetes mellitus, are derived from the polymerization of a putative hormone identified as IAPP. IAPP is synthesized by normal islet beta cells and probably is cosecreted with insulin. Although the physiologic function of IAPP and its role in the pathogenesis of Type II diabetes mellitus are
Franklin H. Epstein, Kenneth H. Johnson, Timothy D. O'Brien, Christer Betsholtz, Per Westermark   +4 more
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Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies

Biological chemistry, 2020
The human islet amyloid polypeptide (hIAPP) or amylin, a neuroendocrine peptide hormone, is known to misfold and form amyloidogenic aggregates that have been observed in the pancreas of 90% subjects with Type 2 Diabetes Mellitus (T2DM).
Ajit Kumar Bishoyi, Pratiksha H. Roham, Kavitha Rachineni, Shreyada Save, M. Hazari, Shilpy Sharma, Ashutosh Kumar   +6 more
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Targeting Human Islet Amyloid Polypeptide Aggregation and Toxicity in Type 2 Diabetes: An Overview of Peptide-Based Inhibitors.

Chemical Research in Toxicology, 2020
Type 2 diabetes (T2D) is a chronic metabolic disease characterized by insulin resistance and a progressive loss of pancreatic islet β-cell mass, which leads to insufficient secretion of insulin and hyperglycemia.
Rajneet Kaur Saini, Deepti Goyal, Bhupesh Goyal   +2 more
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Islet Amyloid Polypeptide and Diabetes

Current Protein & Peptide Science, 2013
Islet amyloid polypeptide (IAPP, amylin) is a 37 amino acid residue hormone expressed mainly by pancreatic islet beta cells and to less extent by some gastrointestinal endocrine cells and by certain regions in central nervous system. In experimental systems a number of different effects have been ascribed to IAPP but the in vivo importance of many of ...
Gunilla T, Westermark, Per, Westermark
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The Human Islet Amyloid Polypeptide in Protein Misfolding Disorders: Mechanisms of Aggregation and Interaction with Biomembranes.

Chemistry and Physics of Lipids, 2020
Human islet amyloid polypeptide (hIAPP), otherwise known as amylin, is a 37-residue peptide hormone which is reported to be a common factor in protein misfolding disorders such as type-2 diabetes mellitus, Alzheimer's disease and Parkinson's disease, due
Adam El Saghir, Gianluca Farrugia, N. Vassallo   +2 more
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