Results 211 to 220 of about 20,996 (256)

Tetracycline derivatives resist the assembly behavior of human islet amyloid polypeptide.

Biochimie, 2020
The misfolding of amyloid proteins is closely correlated with the pathogenesis of protein conformation-related diseases, such as Alzheimer's disease (AD), prion disease, and type 2 diabetes mellitus (T2DM).
Jufei Xu, Cong Zhao, Xiangyi Huang, W. Du   +3 more
semanticscholar   +1 more source

Misfolding of a Human Islet Amyloid Polypeptide at the Lipid Membrane Populates through β-Sheet Conformers without Involving α-Helical Intermediates.

Journal of the American Chemical Society, 2019
Amyloid formation has been implicated in many fatal diseases, but its mechanism remains to be clarified due to a lack of effective methods that can capture the transient intermediates.
Junjun Tan, Jiahui Zhang, Yi Luo, Shuji Ye   +3 more
semanticscholar   +1 more source

Renal Elimination of Islet Amyloid Polypeptide

Biochemical and Biophysical Research Communications, 1997
Six healthy volunteers showed significantly higher plasma islet amyloid polypeptide levels following an oral glucose tolerance test compared to fasting levels. The urine IAPP concentration before and after the OGTT was comparable to that in plasma. Reverse phase HPLC and radioimmunoassay analysis of urine samples revealed a single IAPP-immunoreactive ...
A, Leckström, K, Björklund, J, Permert, R, Larsson, P, Westermark   +4 more
openaire   +2 more sources

Molecular biology of islet amyloid polypeptide

Diabetes Research and Clinical Practice, 1992
We investigated the relationship between non-insulin-dependent diabetes mellitus (NIDDM) and islet amyloid polypeptide (IAPP) gene by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-direct sequencing analysis. Endonuclease BglII and/or PvuII RFLP analysis revealed no positive correlation of IAPP gene with NIDDM.
M, Nishi, T, Sanke, S, Ohagi, K, Ekawa, H, Wakasaki, K, Nanjo, G I, Bell, D F, Steiner   +7 more
openaire   +2 more sources

Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets

Diabetes, 1993
This study investigated the effect of glucose on islet amyloid polypeptide secretion, content, and mRNA synthesis of human pancreatic islets. The release of islet amyloid polypeptide from fresh isolated islets in response to glucose was parallel to that of insulin.
A, Novials, Y, Sarri, R, Casamitjana, F, Rivera, R, Gomis   +4 more
openaire   +2 more sources

Introduction and Fundamentals of Human Islet Amyloid Polypeptide Inhibitors.

ACS Applied Bio Materials, 2020
Type 2 diabetes (T2D) is a common protein misfolding disease (PMD), and its pathogenesis is considered to be tightly associated with the aggregation of the disease-causative hIAPP (or amylin).
Yijing Tang, Dong Zhang, Yanxian Zhang, Yonglan Liu, Xiong Gong, Yung Chang, Baiping Ren, Jie Zheng   +7 more
semanticscholar   +1 more source

Islet amyloid polypeptide and type 2 diabetes

Experimental Gerontology, 2003
Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may have an important role in beta-cell ...
Lucy, Marzban, Kirily, Park, C Bruce, Verchere   +2 more
openaire   +2 more sources

Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity.

Biochemical Journal, 2019
The human islet amyloid polypeptide (hIAPP) or amylin is the major constituent of amyloidogenic aggregates found in pancreatic islets of type 2 diabetic patients that have been associated with β-cell dysfunction and/or death associated with type 2 ...
Richa Dubey, Ketaki C Patil, S. Dantu, Devika M. Sardesai, Parnika Bhatia, Nikita Malik, Jhankar Acharya, Soham Sarkar, Soumadwip Ghosh, R. Chakrabarti, Shilpy Sharma, Ashutosh Kumar   +11 more
semanticscholar   +1 more source

Reactive Conjugated Polymers for the Modulation of Islet Amyloid Polypeptide Assembly.

ACS Applied Materials and Interfaces, 2019
Misfolding and abnormal assembly of proteins cause many intractable diseases. The modulation of the assembly process of these proteins could contribute to understanding and controlling amyloid protein aggregation.
Han Sun, Fengting Lv, Libing Liu, Shu Wang   +3 more
semanticscholar   +1 more source

Islet Amyloid Polypeptide (IAPP) A short review

Acta Oncologica, 1991
The islet amyloid polypeptide (IAPP) was originally identified by chemical analysis of the amyloid component in a human pancreatic islet cell tumor. It consists of 37 amino acids and displays about 50% homology with the neuropeptide calcitonin gene-related peptide (CGRP).
M, Stridsberg, E, Wilander
openaire   +2 more sources