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Transplant Islets Into the Pinna of the Ear: A Mouse Islet Transplant Model
Transplantation Proceedings, 2021Islets transplanted under the ear skin would allow easy observation of the graft response and survival in vivo. This research was designed to establish an efficient mouse islet transplant model to probe the dynamic cellular interplay in vivo.Green fluorescent protein transgenic mice and BALB/c mice were used as donors and recipients.
Lingling Wei +8 more
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Islet Transplantation in Children
Current Gastroenterology Reports, 2019Transplantation of the islets of Langerhans or the pancreas aims to restore blood sugar control. We review both forms of transplantation in children.Allogenic islet transplantation typically in to the liver via the portal vein may be a potential alternative to pancreas transplantation in the future.
Khalid, Khan, Chirag S, Desai
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Seminars in Pediatric Surgery, 2014
Islet transplantation has become a promising treatment for selected patients with type 1 diabetes. Here we provide an overview of the procedure including its history, the process of donor selection, and the techniques and procedures involved in a successful transplant.
Michael, McCall, A M James, Shapiro
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Islet transplantation has become a promising treatment for selected patients with type 1 diabetes. Here we provide an overview of the procedure including its history, the process of donor selection, and the techniques and procedures involved in a successful transplant.
Michael, McCall, A M James, Shapiro
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Pancreas and Islet Transplantation
2001The aim of pancreas and islet transplantation is to establish the same status of glucose control that is provided by endogenous secretion of insulin from a healthy native pancreas in order to improve the quality of life and ameliorate secondary diabetic complications in patients with type I insulin-dependent diabetes mellitus (IDDM).
Nadey, Hakim, V, Papalois
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Current Opinion in Organ Transplantation, 2008
The transplantation of human islets has come a long way since the first diabetic person became insulin independent in 1989. The advent of a steroid-free immunosuppressive protocol in 2000 resulted in most recipients becoming insulin independent and remaining so for a year. However, beta-cell function declines thereafter. Strategies to enhance the islet
Vijayaganapathy, Vaithilingam +2 more
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The transplantation of human islets has come a long way since the first diabetic person became insulin independent in 1989. The advent of a steroid-free immunosuppressive protocol in 2000 resulted in most recipients becoming insulin independent and remaining so for a year. However, beta-cell function declines thereafter. Strategies to enhance the islet
Vijayaganapathy, Vaithilingam +2 more
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Allogeneic islet transplantation
Expert Opinion on Biological Therapy, 2007Significant progress has been made in the field of beta-cell replacement therapies by islet transplantation in patients with unstable Type 1 diabetes mellitus (T1DM). Recent clinical trials have shown that islet transplantation can reproducibly lead to insulin independence when adequate islet numbers are implanted.
Simona, Marzorati +2 more
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History of islet transplantation
Current Diabetes Reports, 2009Patients with a diagnosis of type 1 diabetes mellitus endure stringent life-long medical therapy through the use of insulin to prevent end organ complications and maintain normoglycemia. However, some patients still suffer from hypoglycemic unawareness, even under intensive therapy.
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Pancreatic and islet transplantation
Current Gastroenterology Reports, 2000Diabetes mellitus is the most devastating chronic disease of all time. This review discusses the current therapies for type 1 diabetes that are predicated on the restoration of insulin secretion by transplantation. Recent developments in vascularized pancreas transplantation have led to a dramatic increase in the number of these procedures performed ...
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Pancreatic islet transplantation
British Medical Bulletin, 1989Successful transplantation of the endocrine pancreas in Type I diabetes with complete correction of the glucose metabolic abnormalities may prevent progression or development of the microangiopathic complications of the disease. This could be achieved by transplantation of the whole pancreas as a vascularized graft (the only available clinical approach
P J, Morris, D W, Gray, R, Sutton
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Clinical Islet Transplantation: A Review
Annals of the New York Academy of Sciences, 1999ABSTRACT: For decades, the inability of insulin therapy to physiologically control glycemia in type I diabetic patients has motivated the search for insulin‐delivering grafts. Islet autotransplantation is such a therapeutic approach to prevent diabetes mellitus following a major pancreatectomy, whereas allo‐transplantation is generally prescribed for ...
Oberholzer, José +3 more
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