Results 171 to 180 of about 424,952 (202)
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Current Opinion in Organ Transplantation, 2008
The transplantation of human islets has come a long way since the first diabetic person became insulin independent in 1989. The advent of a steroid-free immunosuppressive protocol in 2000 resulted in most recipients becoming insulin independent and remaining so for a year. However, beta-cell function declines thereafter. Strategies to enhance the islet
Vijayaganapathy, Vaithilingam +2 more
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The transplantation of human islets has come a long way since the first diabetic person became insulin independent in 1989. The advent of a steroid-free immunosuppressive protocol in 2000 resulted in most recipients becoming insulin independent and remaining so for a year. However, beta-cell function declines thereafter. Strategies to enhance the islet
Vijayaganapathy, Vaithilingam +2 more
openaire +2 more sources
Transplantation of Pancreatic Islets
Annual Review of Immunology, 1984The complications in diabetes mellitus develop over many years. They involve the eye, kidney, and cardiovascular system and may lead to blindness, renal failure, and early development of arteriosclerosis. Apparently these compli cations are secondary to the diabetic state and are due to the inability of our present forms of therapy to maintain the ...
P E, Lacy, J M, Davie
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Transplant Islets Into the Pinna of the Ear: A Mouse Islet Transplant Model
Transplantation Proceedings, 2021Islets transplanted under the ear skin would allow easy observation of the graft response and survival in vivo. This research was designed to establish an efficient mouse islet transplant model to probe the dynamic cellular interplay in vivo.Green fluorescent protein transgenic mice and BALB/c mice were used as donors and recipients.
Lingling Wei +8 more
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Pancreas and Islet Transplantation
2001The aim of pancreas and islet transplantation is to establish the same status of glucose control that is provided by endogenous secretion of insulin from a healthy native pancreas in order to improve the quality of life and ameliorate secondary diabetic complications in patients with type I insulin-dependent diabetes mellitus (IDDM).
Nadey, Hakim, V, Papalois
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Pancreas and islet transplantation
The Japanese Journal of Surgery, 1977AbstractConsiderable evidence supports the hypothesis that the microangiopathic lesions of diabetes are secondary to disordered metabolism. This hypothesis underlies the rationale for whole pancreas and islet transplantation. Whole pancreas transplantation has had limited clinical success—only 1 of 47 recipients reported to the ACS/NIH Transplant ...
J S, Najarian +2 more
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Islet Transplantation in Children
Current Gastroenterology Reports, 2019Transplantation of the islets of Langerhans or the pancreas aims to restore blood sugar control. We review both forms of transplantation in children.Allogenic islet transplantation typically in to the liver via the portal vein may be a potential alternative to pancreas transplantation in the future.
Khalid, Khan, Chirag S, Desai
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Sirolimus and islet transplants
Transplantation Proceedings, 2003IMMUNOSUPPRESSION is a critical determinant of the success of islet transplants. Tailoring immunosuppression to the specific setting of marginal mass islet cell transplants in autoimmune type 1 diabetic recipients would likely increase the safety, success rate, and applicability of such transplants.
B J, Hering, M, Wijkstrom
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Pancreatic islet transplantation
British Medical Bulletin, 1989Successful transplantation of the endocrine pancreas in Type I diabetes with complete correction of the glucose metabolic abnormalities may prevent progression or development of the microangiopathic complications of the disease. This could be achieved by transplantation of the whole pancreas as a vascularized graft (the only available clinical approach
P J, Morris, D W, Gray, R, Sutton
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History of islet transplantation
Current Diabetes Reports, 2009Patients with a diagnosis of type 1 diabetes mellitus endure stringent life-long medical therapy through the use of insulin to prevent end organ complications and maintain normoglycemia. However, some patients still suffer from hypoglycemic unawareness, even under intensive therapy.
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Advances in Encapsulation and Delivery Strategies for Islet Transplantation
Advanced Healthcare Materials, 2021Jun Wu, Hai Huang, Jun Wu
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