Results 41 to 50 of about 21,364 (194)

Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes

Frontiers in Endocrinology, 2021
Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the ...
Fritz Cayabyab, Lina R. Nih, Lina R. Nih, Eiji Yoshihara, Eiji Yoshihara   +4 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Amyloid and Transplanted Islets [PDF]

New England Journal of Medicine, 2008
TO THE EDITOR: In their letter to the editor, Westermark and colleagues (Aug. 28 issue)1 report on their identification of amyloid in 43% of intrahepatically transplanted islets on postmortem examination of a recipient with type 1 diabetes. Amyloid is composed of amylin (islet amyloid polypeptide [IAPP]) that is cosecreted from the beta cell with ...
Michael R, Rickels, Heather W, Collins, Ali, Naji   +2 more
openaire   +2 more sources

Perfusion Techniques in Kidney Allograft Preservation to Reduce Ischemic Reperfusion Injury: A Systematic Review and Meta-Analysis

Antioxidants
The limited supply and rising demand for kidney transplantation has led to the use of allografts more susceptible to ischemic reperfusion injury (IRI) and oxidative stress to expand the donor pool.
Bima J. Hasjim, Jes M. Sanders, Michael Alexander, Robert R. Redfield, Hirohito Ichii   +4 more
doaj   +1 more source

Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation

Journal of Diabetes Research, 2014
Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future ...
Haitao Zhu, Liang Yu, Yayi He, Bo Wang
doaj   +1 more source

Bioenergetics of Islet Preparations in a Pilot Clinical Trial of Peri-Transplant Hydroxychloroquine for Autologous Islet Transplantation

Cell Transplantation, 2021
The inflammatory response is an obstacle to success in both allogeneic and autologous islet transplantation. In autologous islet transplantation (AIT), however, the recipient is also the donor, permitting pretreatment of donor/recipient for a controlled ...
Ruth E. McDowell PhD, Khawla F. Ali MD, Saloni Lad MA, Vicente T. San Martin MD, Rita Bottino PhD, Matthew Walsh MD, Tyler Stevens MD, William Wilke MD, John P. Kirwan PhD, Betul Hatipoglu MD   +9 more
doaj   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Xenogeneic islet transplantation

Xenotransplantation, 1999
Simeonivic C J. Xenogeneic islet transplantation. Xenotransplantation 1999; 6: 00‐00. ©Munksgaard, Copenhagen.
openaire   +3 more sources

A case of abdominal abscess after simultaneous omentum intraomental bio-scaffold islet-kidney transplantation

Journal of Pancreatology, 2023
Compared with patients who undergo renal and islet transplantation sequentially, simultaneous omentum intraomental bio-scaffold islet-kidney transplantation in patients with type 1 diabetes complicated by renal failure has the advantages of donor ...
Zewen Liu, Guanghui Pei, Xiangheng Cai, Jiaqi Zou, Xuejie Ding, Peng Sun, Rui Liang, Boya Zhang, Shusen Wang   +8 more
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source