Results 61 to 70 of about 424,952 (202)

Xenogeneic islet transplantation

Xenotransplantation, 1999
Simeonivic C J. Xenogeneic islet transplantation. Xenotransplantation 1999; 6: 00‐00. ©Munksgaard, Copenhagen.
openaire   +3 more sources

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Globally widespread weeds show preadaptation to non‐analogue climates: a common garden approach

Oikos, EarlyView.
Climatic niche shifts have been documented for plant species introduced into new regions, however the underlying mechanisms are poorly understood. Niche shifts into novel climates are particularly difficult to predict as previous occurrence data cannot reveal whether these novel climates are within species' fundamental niche limits.
Thomas Frank Carlin, Jennifer L. Bufford, Philip E. Hulme, William K. Godsoe   +3 more
wiley   +1 more source

Seven Consecutive Successful Clinical Islet Isolations with Pancreatic Ductal Injection

Cell Transplantation, 2010
Inconsistent islet isolation is one of the issues of clinical islet transplantation. In the current study, we applied ductal injection to improve the consistency of islet isolation.
Shinichi Matsumoto M.D., Ph.D., Hirofumi Noguichi, Masayuki Shimoda, Tetsuya Ikemoto, Bashoo Naziruddin, Andrew Jackson, Yoshiko Tamura, Greg Olson, Yasutaka Fujita, Daisuke Chujo, Morihito Takita, Naoya Kobayashi, Nicholas Onaca, Marlon Levy   +13 more
doaj   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

β cell replacement therapy for the cure of diabetes

Journal of Diabetes Investigation, 2022
Islet transplantation is an important option in the treatment of type 1 diabetes. However, a donor shortage and immunosuppressant‐related complications are the current major hurdles of islet transplantation.
Joonyub Lee, Kun‐Ho Yoon
doaj   +1 more source

Transplantation and Islet Topics [PDF]

Diabetes Care, 2005
This is the fourth in a series of articles on presentations at the American Diabetes Association Annual Meeting, Orlando, Florida, 4–8 June 2004. The American Society of Transplantation (www.a-s-t.org) held a symposium at the June ADA meeting addressing the importance of diabetes following transplantation (1).
openaire   +2 more sources

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Islet transplantation improved penile tissue fibrosis in a rat model of type 1 diabetes

BMC Endocrine Disorders, 2018
Background Glycaemic control is one of the most effective strategies for the treatment of diabetes-related erectile dysfunction (DMED). Compared to conventional anti-diabetic drugs and insulin, islet transplantation is more effective in the treatment of ...
Zhigang Wu, Hongwei Wang, Fubiao Ni, Xuan Jiang, Ziqiang Xu, Chengyang Liu, Yong Cai, Hongxing Fu, Jiao Luo, Wenwei Chen, Bicheng Chen, Zhixian Yu   +11 more
doaj   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source