Results 61 to 70 of about 21,364 (194)

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source

Pancreas and islet transplantation

Journal of British Surgery, 1992
81624
LONDON, NJM, BELL, PRF
openaire   +3 more sources

β cell replacement therapy for the cure of diabetes

Journal of Diabetes Investigation, 2022
Islet transplantation is an important option in the treatment of type 1 diabetes. However, a donor shortage and immunosuppressant‐related complications are the current major hurdles of islet transplantation.
Joonyub Lee, Kun‐Ho Yoon
doaj   +1 more source

Superiority of Small Islets in Human Islet Transplantation [PDF]

Diabetes, 2007
Many factors influence the outcome of islet transplantation. As islets in the early posttransplant setting are supplied with oxygen by diffusion only and are in a hypoxic state in the portal system, we tested whether small human islets are superior to large islets both in vitro and in vivo.
Lehmann, R, Zuellig, R A, Kugelmeier, P, Baenninger, P B, Moritz, W, Perren, A, Clavien, P A, Weber, M, Spinas, G A   +8 more
openaire   +5 more sources

Day‐30 IL1RL1, CXCL9 and REG3α are prognostic for survival after mismatched unrelated donor transplantation

British Journal of Haematology, EarlyView.
Summary While plasma‐derived proteins have emerged as potential biomarkers for prognosis after haematopoietic stem cell transplantation (HSCT), there are insufficient data assessing if established proteins interleukin 1 receptor‐like 1 (IL1RL1), chemokine ligand 9 (CXCL9) and regenerating islet‐derived 3‐α (REG3α) retain their utility in the mismatched
Trent Wang, Anna C. Ferreira, Nasheed M. Hossain, Denggang Fu, Elizabeth G. Hill, Antonio M. Jimenez Jimenez, Cara Benjamin, Krishna V. Komanduri, Sophie Paczesny   +8 more
wiley   +1 more source

Islet alloautotransplantation: Allogeneic pancreas transplantation followed by transplant pancreatectomy and islet transplantation [PDF]

American Journal of Transplantation, 2018
Simultaneous pancreas-kidney (SPK) transplantation is an important treatment option for patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD). Due to complications, in up to 10% of patients, allograft pancreatectomy is necessary shortly after transplantation. Usually the donor pancreas is discarded. Here, we report on a novel procedure
Nijhoff, M.F., Dubbeld, J., Erkel, A.R. van, Boog, P.J.M. van der, Rabelink, T.J., Engelse, M.A., Koning, E.J.P. de   +6 more
openaire   +3 more sources

Islet transplantation improved penile tissue fibrosis in a rat model of type 1 diabetes

BMC Endocrine Disorders, 2018
Background Glycaemic control is one of the most effective strategies for the treatment of diabetes-related erectile dysfunction (DMED). Compared to conventional anti-diabetic drugs and insulin, islet transplantation is more effective in the treatment of ...
Zhigang Wu, Hongwei Wang, Fubiao Ni, Xuan Jiang, Ziqiang Xu, Chengyang Liu, Yong Cai, Hongxing Fu, Jiao Luo, Wenwei Chen, Bicheng Chen, Zhixian Yu   +11 more
doaj   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

The Use of Biomaterials in Islet Transplantation [PDF]

Current Diabetes Reports, 2011
Pancreatic islet transplantation is a therapeutic option to replace destroyed β cells in autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however, inflammation, the required immunosuppression, and lack of vasculature decrease early islet viability and function.
Borg, Danielle J., Bonifacio, Ezio
openaire   +5 more sources

SUITO Index for Evaluation of Efficacy of Single Donor Islet Transplantation

Cell Transplantation, 2009
Evaluation of engrafted islets mass is important for clinical care of patients after islet transplantation. Recently, we developed the secretory unit of islet transplant objects (SUITO) index, which reflected engrafted islet mass.
Shinichi Matsumoto M.D., Ph.D., Hirofumi Noguchi, Nobuyo Hatanaka, Masayuki Shimoda, Naoya Kobayashi, Andrew Jackson, Nicholas Onaca, Bashoo Naziruddin, Marlon F. Levy   +8 more
doaj   +1 more source