Results 81 to 90 of about 424,952 (202)
Key factors for human islet isolation and clinical transplantation
, 2005 Background. To further improve the outcome of clinical islet transplantation analysis of the impact of donor- and process-related factors could be of great importance. Materials and Methods.
Foss, A +16 more
core +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Islet transplantation in Korea
Journal of Diabetes InvestigationType 1 diabetes mellitus is characterized by absolute insulin deficiency, which requires life‐long insulin replacement. Exogenous multiple‐daily insulin injections are most commonly prescribed for patients with type 1 diabetes mellitus. However, exogenous insulin supply often fails to cope with real‐time changing life‐log variables, such as activity ...
Joonyub Lee, Kun‐Ho Yoon
openaire +3 more sources
Journal of Diabetes Investigation, EarlyView.ABSTRACT Over the past century, the discovery of insulin transformed type 1 diabetes from a fatal disease into a manageable chronic condition, and the subsequent recognition of its autoimmune basis laid the foundation for screening and intervention before clinical onset.
Noriko Kodani
wiley +1 more source
ATP measurement predicts porcine islet transplantation outcome in nude mice
, 2009 Current nude mice islet transplantation studies cannot be used prospectively. Therefore, to predict transplantation outcomes, reliable and rapid assays for islet quality assessment are warranted.
김형일
core +1 more source
A Model for Human Islet Transplantation to Immunodeficient Streptozotocin-Induced Diabetic Mice
Cell Transplantation, 2018 Streptozotocin (STZ) is a cytotoxic glucose analogue that causes beta cell death and is widely used to induce experimental diabetes in rodents. The sensitivity of beta cells to STZ is species-specific and human beta cells are resistant to STZ.
Elisabet Estil·les +3 more
doaj +1 more source
Genes, fish and fisheries: translating science into policy
Journal of Fish Biology, EarlyView.Abstract The 2024 Annual Symposium of the Fisheries Society of the British Isles reviewed the burgeoning impact of ‘omics’ technologies on fish ecology, management and forecasting. As with life sciences more generally, major advances in speed, cost‐effectiveness and breadth of applications in ‘omics’ has had profound societal and environmental impacts.
Gary R. Carvalho
wiley +1 more source
Experimental approaches to the prevention of islet rejection
, 2010 Chapter 21 focuses on experimental studies of allogeneic islet cell transplantation, with an emphasis on recent advances in the prevention of rejection, as exemplified by studies in rodents and nonhuman primates (NHP)
Kenyon, Norma S. +3 more
core +1 more source
Comparison of the Ovary and Kidney as Sites for Islet Transplantation in Diabetic Rats
, 2016 Background. Currently, the most commonly used site for clinical islet transplantation is the liver although it is far from being an ideal site. Low oxygen tension and the induction of an inflammatory response impair islet implantation and lead to ...
Delibasi, T. +17 more
core +2 more sources
Implication of Mitochondrial Cytoprotection in Human Islet Isolation and Transplantation
Biochemistry Research International, 2012 Islet transplantation is a promising therapy for type 1 diabetes mellitus; however, success rates in achieving both short- and long-term insulin independence are not consistent, due in part to inconsistent islet quality and quantity caused by the complex
Yong Wang +9 more
doaj +1 more source