Results 71 to 80 of about 424,952 (202)

Isolating Human Islets of Langerhans Causes Loss of Decay Accelerating Factor (CD55) on β-Cells

Cell Transplantation, 2008
It has previously been reported that human decay accelerating factor (DAF; CD55) is not expressed on cells isolated from human islets. We have investigated if this absence is caused by the islet isolation procedure and/or the single cell isolation ...
Joo Ho Tai, Hongtao Sun, Weihua Liu, C. W. James Melling, Craig Hasilo, David J. G. White   +5 more
doaj   +1 more source

Islet alloautotransplantation: Allogeneic pancreas transplantation followed by transplant pancreatectomy and islet transplantation [PDF]

American Journal of Transplantation, 2018
Simultaneous pancreas-kidney (SPK) transplantation is an important treatment option for patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD). Due to complications, in up to 10% of patients, allograft pancreatectomy is necessary shortly after transplantation. Usually the donor pancreas is discarded. Here, we report on a novel procedure
Nijhoff, M.F., Dubbeld, J., Erkel, A.R. van, Boog, P.J.M. van der, Rabelink, T.J., Engelse, M.A., Koning, E.J.P. de   +6 more
openaire   +3 more sources

Evaluating EndoC βH5 pseudoislets as a model for human islet transplantation

Diabetic Medicine, EarlyView.
Abstract Aims The EndoC βH5 cell line represents a promising human β‐cell model for preclinical diabetes research. Indeed, EndoC βH5 cells aggregate into islet‐like organoids, secrete insulin in a glucose‐dependent manner, and express a variety of β‐cell functional markers.
Lydia F. Daniels Gatward, William T. Blackstone Whines, Tzu‐Wen Hong, Rosie Sullivan, Jessica Starikova, Adya Lonsane, Ryea Arora, Victoria Salem, Min Zhao, Peter M. Jones, Aileen F. J. King, Shanta J. Persaud   +11 more
wiley   +1 more source

Extended pancreas donor program - the EXPAND study rationale and study protocol [PDF]

, 2013
BACKGROUND: Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenile) diabetes mellitus with or ...
Bechstein, Wolf Otto, Carsten Dietz, Falk Rauchfuss, Holub, Ines, Peter Schenker, Heise, Michael, Volker Müller, Rauchfuss, Falk, Proneth, Andrea, Florian Zeman, Björn Nashan, Markus Guba, Banas, Bernhard, Stefan Thorban, Schemmer, Peter, Edward K Geissler, Stephan Kersting, Ströhlein, Michael A., Andreas A Schnitzbauer, Nashan, Björn, Jonas, Sven, Thomas Becker, Ines Holub, Johanna R Foerster, Andreas Pascher, Manekeller, Steffen, Viebahn, Richard, Müller, Volker, Thomas Vogel, Peter Schemmer, Bernhard Banas, Farkas, Stefan A., Andrea Proneth, Arbogast, Helmut, Schenker, Peter, Richard Viebahn, Thorban, Stefan, Jürgen Klempnauer, Silvio Nadalin, Axel O Rahmel, Vogel, Thomas, Becker, Thomas, Guba, Markus, Zeman, Florian, Kersting, Stephan, Michael Heise, Rahmel, Axel, Klempnauer, Jürgen, Schlitt, Hans J., Schnitzbauer, Andreas, Stefan A Farkas, Nadalin, Silvio, Sven Jonas, Steffen Manekeller, Helmut Arbogast, Hans J Schlitt, Dietz, Carsten, Michael A Ströhlein, Geissler, Edward K., Wolf O Bechstein, Foerster, Johanna R., Pascher, Andreas, Andrea Proneth   +62 more
core   +1 more source

The Use of Biomaterials in Islet Transplantation [PDF]

Current Diabetes Reports, 2011
Pancreatic islet transplantation is a therapeutic option to replace destroyed β cells in autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however, inflammation, the required immunosuppression, and lack of vasculature decrease early islet viability and function.
Borg, Danielle J., Bonifacio, Ezio
openaire   +5 more sources

PPI and researcher perspectives of islet transplantation therapy for type 1 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Islet transplantation offers the potential of a cure for type 1 diabetes (T1D), but the limited availability of human donor islets means that this therapy is currently only available to a small group of people with T1D who have intractable hypoglycaemia.
Peter M. Jones, Sarah Gatward, Lesley Beadle, Amanda Panizza, Clare Blaydon‐Ellis, Sara Caxaria, Aidan Cruddace, Christine Deal, Ranna Patel, Alexander Silverstein, Lydia F. Daniels Gatward, Tzu‐Wen Hong, Rosie Sullivan, William T. Blackstone Whines, Aileen J. F. King, Shanta J. Persaud   +15 more
wiley   +1 more source

Islet Cell Transplantation Procedure and Surgical Technique

, 2014
Compared with solid organ transplantation of liver, pancreas, kidney, heart, or lungs, percutaneous clinical islet transplantation may be considered one of the safest of all the transplant procedures, at least in expert hands.
Camillo Ricordi, Shapiro, A.M. James, Ricordi, Camillo, A.M. James Shapiro   +3 more
core   +1 more source

Cutting edge of immune response and immunosuppressants in allogeneic and xenogeneic islet transplantation

Frontiers in Immunology
As an effective treatment for diabetes, islet transplantation has garnered significant attention and research in recent years. However, immune rejection and the toxicity of immunosuppressive drugs remain critical factors influencing the success of islet ...
Liting Yue, Jisong Li, Mingjun Yao, Siyuan Song, Xiaoqin Zhang, Yi Wang, Yi Wang   +6 more
doaj   +1 more source

SUITO Index for Evaluation of Efficacy of Single Donor Islet Transplantation

Cell Transplantation, 2009
Evaluation of engrafted islets mass is important for clinical care of patients after islet transplantation. Recently, we developed the secretory unit of islet transplant objects (SUITO) index, which reflected engrafted islet mass.
Shinichi Matsumoto M.D., Ph.D., Hirofumi Noguchi, Nobuyo Hatanaka, Masayuki Shimoda, Naoya Kobayashi, Andrew Jackson, Nicholas Onaca, Bashoo Naziruddin, Marlon F. Levy   +8 more
doaj   +1 more source

A DPP6‐Targeted PET Tracer for Non‐Invasive Imaging of Transplanted Human Islets

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation of [68Ga]Ga‐NOTA‐4hD29 for Positron Emission Tomography (PET) imaging of ...
Amina Khalil, Arturo Roca‐Rivada, Svitlana Vasylovska, Lorenzo J. I. Balestri, Irina Velikyan, Sayro Jawurek, Alexandra C. Title, Burcak Yesildag, Luke R. Odell, Joey Lau, Decio L. Eizirik, Olof Eriksson   +11 more
wiley   +1 more source