Results 21 to 30 of about 424,952 (202)

Noradrenergic and Cholinergic Reinnervation of Islet Grafts in Diabetic Rats [PDF]

, 1996
Grafted islets become denervated due to the islet transplantation procedure. The aim of the present study was 1) to examine whether islet grafts in the liver, the spleen, and under the kidney capsule in rats become reinnervated following the ...
Oestreicher, AB, Strubbe, JH, van der Zee, E A, Suylichem, Paul T.R. van,, Oestreicher, A B, Asperen, Roelie M. van,, Strubbe, Jan H.,, VanAsperen, RM, Steffens, Anton B.,, Houwing, H, van Suylichem, P T R, Eddy A. Van Der Zee, Steffens, AB, Zee, Eddy A. van der,, Harmina Houwing, VanderZee, EA, Strubbe, J H, Houwing, Harmina,, van Asperen, R M, Oestreicher, A. Beate,, Jan H. Strubbe, Van Suylichem, PTR, Paul T.R. Van Suylichem, Steffens, A B, Roelie M. Van Asperen, Asperen, Roelie M. van, A. Beate Oestreicher, Anton B. Steffens   +27 more
core   +1 more source

Pancreatic islet transplantation [PDF]

World Journal of Gastrointestinal Surgery, 2009
Type 1 diabetes mellitus is an autoimmune disease, which results in the permanent destruction of β-cells of the pancreatic islets of Langerhans. While exogenous insulin therapy has dramatically improved the quality of life, chronic diabetic complications develop in a substantial proportion of subjects and these complications generally progress and ...
Corrêa-Giannella Maria, Raposo do Amaral Alexandre S   +1 more
openaire   +5 more sources

Effect of Manufacturing Procedures on Human Islet Isolation from Donor Pancreata Standardized by the North American Islet Donor Score

Cell Transplantation, 2017
This study investigates manufacturing procedures that affect islet isolation outcomes from donor pancreata standardized by the North American Islet Donor Score (NAIDS).
Chun-Chieh Yeh, Ling-Jia Wang, James J. Mcgarrigle, Yong Wang, Chien-Chang Liao, Mustafa Omami, Arshad Khan, Mohammad Nourmohammadzadeh, Joshua Mendoza-Elias, Benjamin Mccracken, Enza Marchese, Barbara Barbaro, Jose Oberholzer   +12 more
doaj   +1 more source

Improved Vascularization of Planar Membrane Diffusion Devices following Continuous Infusion of Vascular Endothelial Growth Factor

Cell Transplantation, 2000
Improving blood vessel formation around an immunobarrier device should improve the survival of the encapsulated tissue. In the present study we investigated the formation of new blood vessels around a planar membrane diffusion device (the Baxter ...
N. Trivedi, G. M. Steil, C. K. Colton, S. Bonner-Weir, G. C. Weir M.D.   +4 more
doaj   +1 more source

Graft failure after allogeneic islet transplantation in a patient with type 1 diabetes and a high anti‐glutamic acid decarboxylase antibody titer

Journal of Diabetes Investigation, 2023
Pancreatic islet transplantation is a β‐cell replacement therapy for people with insulin‐deficient diabetes who have difficulty in glycemic control and suffer from frequent severe hypoglycemia. However, the number of islet transplantations carried out is
Noriko Kodani, Daisuke Chujo, Aiko Terakawa, Kyoji Ito, Fuyuki Inagaki, Nobuyuki Takemura, Shinichi Matsumoto, Tsuyoshi Tajima, Norio Ohmagari, Kumiko Ajima, Tadashi Takaki, Yzumi Yamashita, Koya Shinohara, Hiroshi Kajio, Takuya Awata, Masayuki Shimoda   +15 more
doaj   +1 more source

Pancreatic islet basement membrane loss and remodeling after mouse islet isolation and transplantation: impact for allograft rejection [PDF]

, 2014
The isolation of islets by collagenase digestion can cause damage and impact the efficiency of islet engraftment and function. In this study, we assessed the basement membranes (BMs) of mouse pancreatic islets as a molecular biomarker for islet integrity,
Irving-Rodgers, H. F, F. J. Choong, Rodgers, RJ, Choong, F., Irving-Rodgers, HF, Rodgers, R. J., R. J. Rodgers, K. Hummitzsch, Simeonovic, C., Choong, F.J., Irving-Rodgers, H.F., Parish, CR, Rodgers, R., Choong, F. J, Hummitzsch, K, Irving-Rodgers, H., Simeonovic, C.J., Choong, FJ, Rodgers, R.J., Hummitzsch, K., H. F. Irving-Rodgers, C. J. Simeonovic, Parish, C.R., Simeonovic, CJ, Parish, Christopher, C. R. Parish, Simeonovic, Charmaine, Parish, C.   +27 more
core   +2 more sources

Long-term Effect of Islet Transplantation on Glycemic Variability

Cell Transplantation, 2018
Islet transplantation has been reported to restore normoglycemia and the overall metabolic control in type 1 diabetes mellitus (DM). In the most experienced centers, islet transplantation clinical outcome is similar to that of the whole pancreas ...
Federico Bertuzzi, Luciano De Carlis, Mario Marazzi, Antonio Gaetano Rampoldi, Matteo Bonomo, Barbara Antonioli, Marta Cecilia Tosca, Marta Galuzzi, Andrea Lauterio, Danila Fava, Patrizia Dorighet, Andrea De Gasperi, Giacomo Colussi   +12 more
doaj   +1 more source

The Role of Interleukin-1β in Destruction of Transplanted Islets

Cell Transplantation, 2020
Islet transplantation is a promising β-cell replacement therapy for type 1 diabetes, which can reduce glucose lability and hypoglycemic episodes compared with standard insulin therapy. Despite the tremendous progress made in this field, challenges remain
Cheng Chen, Pengfei Rong, Min Yang, Xiaoqian Ma, Zhichao Feng, Wei Wang   +5 more
doaj   +1 more source

Mesenteric lymph nodes as alternative site for pancreatic islet transplantation in a diabetic rat model

BMC Surgery, 2019
Background Islet transplantation has progressively become a safe alternative to pancreas transplantation for the treatment of type 1 diabetes. However, the long-term results of islet transplantation could be significantly increased by improving the ...
Massimiliano Veroux, Rita Bottino, Roberta Santini, Suzanne Bertera, Daniela Corona, Domenico Zerbo, Giovanni Li Volti, Burcin Ekser, Lidia Puzzo, Marco Raffaele, Salvatore Lo Bianco, Alessia Giaquinta, Pierfrancesco Veroux, Luca Vanella   +13 more
doaj   +1 more source

Amniotic Membrane Extract Protects Islets From Serum-Deprivation Induced Impairments and Improves Islet Transplantation Outcome

Frontiers in Endocrinology, 2020
Islet culture prior to transplantation is a standard practice in many transplantation centers. Nevertheless, the abundant islet mass loss and function impairment during this serum-deprivation culture period restrain the success of islet transplantation ...
Zhaoming Yang, Xiaohang Li, Chengshuo Zhang, Ning Sun, Tingwei Guo, Jianzhen Lin, Feng Li, Jialin Zhang   +7 more
doaj   +1 more source