Results 31 to 40 of about 424,952 (202)

Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway

open access: yesInternational Journal of Endocrinology, 2023
Purpose. This study aimed to investigate the potential mechanism underlying the therapeutic effect of sildenafil in combination with islet transplantation for diabetic peripheral neuropathy. Methods.
Xiandong Zhu   +12 more
doaj   +1 more source

The liver surface as a favorable site for islet cell sheet transplantation in type 1 diabetes model mice

open access: yesRegenerative Therapy, 2018
Introduction: Islet transplantation is one of the most promising therapeutic approaches for patients with severe type 1 diabetes mellitus (T1DM). Transplantation of engineered islet cell sheets holds great potential for treating T1DM as it enables the ...
Izumi Fujita   +4 more
doaj   +1 more source

Islet cell transplantation [PDF]

open access: yesPostgraduate Medical Journal, 2007
Abstract People with type 1 diabetes have normal exocrine pancreatic function, making islet cell rather than whole organ transplantation an attractive option. Achieving insulin independence in type 1 diabetes was the perceived goal of islet cell transplantation.
Srinivasan, P   +3 more
openaire   +3 more sources

A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant

open access: yesNano Select, 2023
β‐islet cell transplantation is a promising proposed treatment for type 1 diabetes mellitus (T1DM) which can provide more physiological glucose control when compared to exogenous insulin therapy and reverse secondary consequences of diabetes ...
Anessa Puskar   +4 more
doaj   +1 more source

Islet Transplantation in the UK.

open access: yesCellR4-- repair, replacement, regeneration, & reprogramming, 2019
This commentary outlines the development and current status of the UK Islet Transplant Programme in the UK. The author makes the case that it is now time for similar fully funded beta-cell programmes to be made available in many other countries as well.
Johnson, P. R. V.   +1 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

open access: yesXenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Pancreas and islet transplantation

open access: yesJournal of British Surgery, 1992
81624
LONDON, NJM, BELL, PRF
openaire   +3 more sources

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

open access: yesAdvanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez   +9 more
wiley   +1 more source

Comparison of the Effects of Liraglutide on Islet Graft Survival Between Local and Systemic Delivery

open access: yesCell Transplantation, 2020
Islet transplantation has emerged as a promising treatment for type 1 diabetes mellitus. Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, protects beta cells after islet transplantation by improving glycemic control through several ...
Song Mi Lee   +7 more
doaj   +1 more source

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