Results 31 to 40 of about 21,364 (194)

Fewer Islets Survive from a First Transplant than a Second Transplant: Evaluation of Repeated Intraportal Islet Transplantation in Mice

Cell Transplantation, 2019
Beta cell replacement is an exciting field where new beta cell sources and alternative sites are widely explored. The liver has been the implantation site of choice in the clinic since the advent of islet transplantation. However, in most cases, repeated
Hanna Liljebäck, My Quach, Per-Ola Carlsson, Joey Lau   +3 more
doaj   +1 more source

Amniotic Membrane Extract Protects Islets From Serum-Deprivation Induced Impairments and Improves Islet Transplantation Outcome

Frontiers in Endocrinology, 2020
Islet culture prior to transplantation is a standard practice in many transplantation centers. Nevertheless, the abundant islet mass loss and function impairment during this serum-deprivation culture period restrain the success of islet transplantation ...
Zhaoming Yang, Xiaohang Li, Chengshuo Zhang, Ning Sun, Tingwei Guo, Jianzhen Lin, Feng Li, Jialin Zhang   +7 more
doaj   +1 more source

The liver surface as a favorable site for islet cell sheet transplantation in type 1 diabetes model mice

Regenerative Therapy, 2018
Introduction: Islet transplantation is one of the most promising therapeutic approaches for patients with severe type 1 diabetes mellitus (T1DM). Transplantation of engineered islet cell sheets holds great potential for treating T1DM as it enables the ...
Izumi Fujita, Rie Utoh, Masakazu Yamamoto, Teruo Okano, Masayuki Yamato   +4 more
doaj   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Comparison of the Effects of Liraglutide on Islet Graft Survival Between Local and Systemic Delivery

Cell Transplantation, 2020
Islet transplantation has emerged as a promising treatment for type 1 diabetes mellitus. Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, protects beta cells after islet transplantation by improving glycemic control through several ...
Song Mi Lee, Donghee Kim, Kyung Min Kwak, Phyu Phyu Khin, Oh Kyung Lim, Kwang-Won Kim, Byung-Joon Kim, Hee-Sook Jun   +7 more
doaj   +1 more source

Beneficial effect of insulin treatment on islet transplantation outcomes in Akita mice. [PDF]

PLoS ONE, 2014
Islet transplantation is a promising potential therapy for patients with type 1 diabetes. The outcome of islet transplantation depends on the transplantation of a sufficient amount of β-cell mass. However, the initial loss of islets after transplantation
Kazuhide Kikawa, Daisuke Sakano, Nobuaki Shiraki, Tomonori Tsuyama, Kazuhiko Kume, Fumio Endo, Shoen Kume   +6 more
doaj   +1 more source

Probucol Pharmacological and Bio-Nanotechnological Effects on Surgically Transplanted Graft Due to Powerful Anti-Inflammatory, Anti-Fibrotic and Potential Bile Acid Modulatory Actions

Pharmaceutics, 2021
Introduction. A major obstacle in islet transplantation and graft survival pre and post transplantation is islet apoptosis due to mainly inflammatory bio molecules released during islet harvesting and post graft transplantation and hence, subsequent ...
Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov, Marcus D. Atlas, Hani Al-Salami   +11 more
doaj   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant

Nano Select, 2023
β‐islet cell transplantation is a promising proposed treatment for type 1 diabetes mellitus (T1DM) which can provide more physiological glucose control when compared to exogenous insulin therapy and reverse secondary consequences of diabetes ...
Anessa Puskar, Bara Saadah, Asad Rauf, Szymon R. Kasperek, Muhammad Umair   +4 more
doaj   +1 more source

Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets

Advanced Materials Technologies, EarlyView.
This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu, Qizheng Zhang, Tianli Hu, Juewen Liu, Hongxing Fu, Xin Zhao, Zijiang Yang, Chenjie Xu   +7 more
wiley   +1 more source