Results 11 to 20 of about 21,364 (194)
Pancreatic islet transplantation [PDF]
World Journal of Gastrointestinal Surgery, 2009 Type 1 diabetes mellitus is an autoimmune disease, which results in the permanent destruction of β-cells of the pancreatic islets of Langerhans. While exogenous insulin therapy has dramatically improved the quality of life, chronic diabetic complications develop in a substantial proportion of subjects and these complications generally progress and ...
Corrêa-Giannella Maria +1 more
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Islet assessment for transplantation [PDF]
Current Opinion in Organ Transplantation, 2009 There is a critical need for meaningful viability and potency assays that characterize islet preparations for release prior to clinical islet cell transplantation. Development, testing, and validation of such assays have been the subject of intense investigation for the last decade. These efforts are reviewed, highlighting the most recent results while
Papas, Klearchos K. +2 more
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Islet Cell Transplantation [PDF]
Current Molecular Medicine, 2006 Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The islets, that are only 1% of the total
Bertuzzi F +2 more
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Anti-Oxidative Therapy in Islet Cell Transplantation
Antioxidants, 2022 Islet cell transplantation has become a favorable therapeutic approach in the treatment of Type 1 Diabetes due to the lower surgical risks and potential complications compared to conventional pancreas transplantation.
Natsuki Eguchi +5 more
doaj +1 more source
Islet cell transplantation [PDF]
Postgraduate Medical Journal, 2007 Abstract People with type 1 diabetes have normal exocrine pancreatic function, making islet cell rather than whole organ transplantation an attractive option. Achieving insulin independence in type 1 diabetes was the perceived goal of islet cell transplantation.
Srinivasan, P +3 more
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Current state of pancreas transplantation in Japan based on the nationwide registry
Annals of Gastroenterological Surgery, 2021 In Japan, 437 pancreas transplantations (PTx) were carried out between 2000 and 2019. Clinical data for all PTx cases are registered in the Japan Pancreas Transplant Registry of the Japan Society for Pancreas and Islet Transplantation.
Yoshito Tomimaru +4 more
doaj +1 more source
Subcutaneous device-free islet transplantation
Frontiers in Immunology, 2023 Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is results from insufficient insulin secretion by islets; its treatment ...
Xudong Zhou +8 more
doaj +1 more source
Immunosuppression in islet transplantation [PDF]
Journal of Clinical Investigation, 2008 Islet transplantation can temporarily cure type 1 diabetes mellitus (T1DM) but requires simultaneous immunosuppression to avoid allograft rejection. In this issue of the JCI, Monti et al. report that immune conditioning via use of the Edmonton protocol - a treatment approach in which T1DM patients infused with pancreatic islets from multiple cadaveric ...
Tom, Van Belle, Matthias, von Herrath
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Inflammatory response and its impact on outcome of islet transplantation [PDF]
CellR4, 2019 Inflammation plays a detrimental role in islet transplantation leading to poor clinical outcomes. One of the major contributors of islet loss is IBMIR leading to 50% decrease in transplanted islet mass immediately post-transplantation.
M. Kanak, P. Saravanan, M. Levy
doaj +1 more source
Journal of Hepato-Biliary-Pancreatic Surgery, 2000 Recently, significant advances have been made in the number and purity of islets that can be retrieved from the human pancreas, thus enabling several centers to initiate or resume clinical trials of islet transplantation in type I diabetic patients. Although the success rate of islet transplantation is lower than that of pancreas transplantation in ...
Piemonti L.
europepmc +3 more sources