Results 1 to 10 of about 1,464 (114)
Cell Transplantation, 2008 The evaluation of engraftment is important to assess the success of islet transplantation, but it is complex because islet transplantation usually requires two or more donors to achieve euglycemia. Islet transplantation from NHBDs was evaluated using new
Shinichi Matsumoto +2 more
exaly +2 more sources
Pancreatic islet transplantation: current advances and challenges
Frontiers in ImmunologyDiabetes is a prevalent chronic disease that traditionally requires severe reliance on medication for treatment. Oral medication and exogenous insulin can only temporarily maintain blood glucose levels and do not cure the disease. Most patients need life-
Qi Wang +8 more
exaly +3 more sources
Pancreatic Islet Transplantation
PLoS Medicine, 2004 Islet transplantation offers hope to many patients with diabetes, who envision a life free of glucose checks and insulin injections. What are the barriers to its widespread implementation?
David Harlan
exaly +5 more sources
Frontiers in Pharmacology, 2021 Pancreatic islet transplantation is a minimally invasive procedure to replace β-cells in a subset of patients with autoimmune type 1 diabetic mellitus, who are extremely sensitive to insulin and lack counter-regulatory measures, and thereby increasing ...
George J. Dugbartey +3 more
doaj +1 more source
Scientific Reports, 2022 The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst +3 more
doaj +1 more source
SUCCESSFUL REVERSAL OF HYPERGLYCAEMIA IN DOGS WITHOUT IMMUNOSUPPRESSION [PDF]
Veterinary Medical Journal - Giza, 2002 A natural macro-capsule consisted of a full-term pregnant bitch’s amniotic membrane and pre- served porcine pancreatic islets of Langerhans was implanted intra-abdominally either in the omental pouch (group 1, n=6) or freely in the peritoneum (group 2, n=
M MAHGOUB +5 more
doaj +1 more source
Islet Cell Transplantation [PDF]
Current Molecular Medicine, 2006 Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from whole pancreas. The islets, that are only 1% of the total
Bertuzzi F +2 more
openaire +5 more sources
Clinical Allogeneic and Autologous Islet Cell Transplantation: Update [PDF]
Diabetes & Metabolism Journal, 2011 Islet cell transplantation is categorized as a β-cell replacement therapy for diabetic patients who lack the ability to secrete insulin. Allogeneic islet cell transplantation is for the treatment of type 1 diabetes, and autologous islet cell ...
Shinichi Matsumoto
doaj +1 more source
Islet assessment for transplantation [PDF]
Current Opinion in Organ Transplantation, 2009 There is a critical need for meaningful viability and potency assays that characterize islet preparations for release prior to clinical islet cell transplantation. Development, testing, and validation of such assays have been the subject of intense investigation for the last decade. These efforts are reviewed, highlighting the most recent results while
Papas, Klearchos K. +2 more
openaire +4 more sources
Current state of pancreas transplantation in Japan based on the nationwide registry
Annals of Gastroenterological Surgery, 2021 In Japan, 437 pancreas transplantations (PTx) were carried out between 2000 and 2019. Clinical data for all PTx cases are registered in the Japan Pancreas Transplant Registry of the Japan Society for Pancreas and Islet Transplantation.
Yoshito Tomimaru +4 more
doaj +1 more source