Results 1 to 10 of about 21,364 (194)

Xuebijing injection mitigates instant blood−mediated inflammatory reaction and enhances intrahepatic islet transplantation via target NF−κB pathway [PDF]

Frontiers in Immunology
IntroductionInstant blood-mediated inflammatory reaction (IBMIR) is a major obstacle in clinical islet transplantation, leading to islet apoptosis and dysfunction due to inflammatory reaction.
Yixiang Zhan, Yingbo Wang, Boya Zhang, Yijun Zhang, Rui Liang, Jiuxia Yang, Tengli Liu, Xiaoyan Hu, Tianyi You, Na Liu, Yuqi Chen, Qing Liu, Tingsheng Jiang, Zhaoce Liu, Xiangheng Cai, Runnan Yang, Yingyi Qi, Peng Sun, Jiaqi Zou, Xuejie Ding, Zhuzeng Yin, Shusen Wang   +21 more
doaj   +2 more sources

Secretory Unit of Islet in Transplantation (SUIT) and Engrafted Islet Rate (EIR) Indexes Are Useful for Evaluating Single Islet Transplantation

Cell Transplantation, 2008
The evaluation of engraftment is important to assess the success of islet transplantation, but it is complex because islet transplantation usually requires two or more donors to achieve euglycemia. Islet transplantation from NHBDs was evaluated using new
Hirofumi Noguchi, Teru Okitsu, Yasuhiro Iwanaga   +2 more
exaly   +2 more sources

Pancreatic islet transplantation: current advances and challenges [PDF]

Frontiers in Immunology
Diabetes is a prevalent chronic disease that traditionally requires severe reliance on medication for treatment. Oral medication and exogenous insulin can only temporarily maintain blood glucose levels and do not cure the disease. Most patients need life-
Qi Wang, Yu-xi Huang, Long Liu, Xiao-hong Zhao, Yi Sun, Xinli Mao, Xinli Mao, Shao-wei Li, Shao-wei Li   +8 more
doaj   +2 more sources

Cutting edge of immune response and immunosuppressants in allogeneic and xenogeneic islet transplantation [PDF]

Frontiers in Immunology
As an effective treatment for diabetes, islet transplantation has garnered significant attention and research in recent years. However, immune rejection and the toxicity of immunosuppressive drugs remain critical factors influencing the success of islet ...
Liting Yue, Jisong Li, Mingjun Yao, Siyuan Song, Xiaoqin Zhang, Yi Wang, Yi Wang   +6 more
doaj   +2 more sources

Islet Transplantation: Current Limitations and Challenges for Successful Outcomes [PDF]

Cells
Islet transplantation is a promising approach for treating patients with unstable T1DM. However, it is confronted with numerous obstacles throughout the various stages of the transplantation procedure.
Allan Langlois, Michel Pinget, Laurence Kessler, Karim Bouzakri   +3 more
doaj   +2 more sources

A microporous liraglutide-releasing silk fibroin scaffold improves islet transplantation outcomes through anti-inflammatory effect [PDF]

Cell Transplantation
Islet transplantation represents one of the most promising therapies for curing type 1 diabetes, yet it encounters significant challenges, including early islet damage due to inflammation and hypoxia, which complicate engraftment and survival within the ...
Yixiang Zhan, Xinchen Du, Yan Li, Yingbo Wang, Xiangheng Cai, Runnan Yang, Tingsheng Jiang, Zhaoce Liu, Xueer Yu, Shanshan Lin, Qing Liu, Yingyi Qi, Rui Liang, Na Liu, Tengli Liu, Xiaoyan Hu, Jiaqi Zou, Xuejie Ding, Peng Sun, Houhan Feng, Jiuxia Yang, Lianyong Wang, Shusen Wang   +22 more
doaj   +2 more sources

Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients With Severe Type 1 Diabetes Mellitus

Frontiers in Pharmacology, 2021
Pancreatic islet transplantation is a minimally invasive procedure to replace β-cells in a subset of patients with autoimmune type 1 diabetic mellitus, who are extremely sensitive to insulin and lack counter-regulatory measures, and thereby increasing ...
George J. Dugbartey, George J. Dugbartey, George J. Dugbartey, George J. Dugbartey   +3 more
doaj   +1 more source

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors

Scientific Reports, 2022
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson   +3 more
doaj   +1 more source

SUCCESSFUL REVERSAL OF HYPERGLYCAEMIA IN DOGS WITHOUT IMMUNOSUPPRESSION [PDF]

Veterinary Medical Journal - Giza, 2002
A natural macro-capsule consisted of a full-term pregnant bitch’s amniotic membrane and pre- served porcine pancreatic islets of Langerhans was implanted intra-abdominally either in the omental pouch (group 1, n=6) or freely in the peritoneum (group 2, n=
M MAHGOUB, A AMMAR, Y KHAMIS, E SHETA, H ABDEI AZIZ, A EDRIS   +5 more
doaj   +1 more source

Clinical Allogeneic and Autologous Islet Cell Transplantation: Update [PDF]

Diabetes & Metabolism Journal, 2011
Islet cell transplantation is categorized as a β-cell replacement therapy for diabetic patients who lack the ability to secrete insulin. Allogeneic islet cell transplantation is for the treatment of type 1 diabetes, and autologous islet cell ...
Shinichi Matsumoto
doaj   +1 more source