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Culture of the islets of Langerhans for transplantation
The Japanese Journal of Surgery, 1982The isolated islets of Langerhans are the most available donors for transplantation. As the preservation of the isolated islets is difficult, we attempted to keep these tissues viable by use of an organ culture. Islets of Langerhans from adult Wistar rats were isolated by a collagenase technique and cultured in air-CO2 (95-5%) incubator at 37 degrees C.
Itsuo Miyazaki +2 more
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Synthesis of glycosaminoglycans by islets of Langerhans
Life Sciences, 1988Incorporation of (35S)-sulfate into glycosaminoglycans (GAG) of toadfish islets of Langerhans in vitro was examined. (35S)-sulfated GAG were synthesized by a component of the microsomal fraction, and subsequently transferred to the secretion granules, mitochondria and nuclei.
Dudley T. Watkins, S.J. Cooperstein
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Neuropeptides in the Control of the Islets of Langerhans
1983Publisher Summary This chapter discusses the functions of neuropeptides in the control of the islets of Langerhans. The pancreatic islets of Langerhans are the major regulatory centers involved in blood glucose homeostasis. Each consists of a complex of intimately linked endocrine cells capable of responding to a wide variety of metabolic, neural ...
Julia M. Polak, S.M. Wood, S.R. Bloom
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Glucoreceptor Mechanisms in Islets of Langerhans
Diabetes, 1972A widely accepted concept has been that metabolites of glucose or factors associated with glucose metabolism, rather than glucose itself, trigger insulin release from the β cells. If this concept is correct, levels of metabolites or cofactors or of both should change within seconds of the glucose pulse.
J.E. Ellerman +3 more
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Multiple Transplantations of Islets of Langerhans
European Surgical Research, 1977In 6 diabetic rats about 1,000 isolated islets of Langerhans were transplanted into the liver with little effect on the uninsulinism and hyperglycemia. Subsequently, a second transplantation resulted in a decrease of blood sugar to normal and in a reversal of the loss in body weight. Finally, in animals who had reversed to diabetes again, a third islet
Pichlmayr, Löhlein D, Rumpf Kd
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Transplantation of islets of Langerhans
Journal of Hepato-Biliary-Pancreatic Surgery, 1994The present study attempts to evaluate the possibility of using cryopreserved pancreatic islets in rats. Insulin-releasing activity was studied for the purpose of clarifying the function of cryopreserved islets. Cryopreserved pancreatic islets were also transplanted into the portal veins of recipient rats.
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CARCINOMA OF THE ISLETS OF LANGERHANS
The Lancet, 1955SCOPUS: ar.j ; info:eu-repo/semantics ...
Cleempoel, H. +2 more
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The Function of the Islets of Langerhans
1983The islets of Langerhans play an essential role in regulating nutrient homeostasis in man. They function to ensure that despite wide fluctuations in the supply of certain nutrients in the diet, the concentration of these nutrients in the blood is maintained at a level appropriate to the varying and competing needs of the tissues of the body.
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Effects of epicatechin on rat islets of Langerhans
Diabetes, 1984Plants containing epicatechin (a flavonoid) have been used to treat diabetes mellitus in Indian medicine. The present study reports effects of this compound on isolated islets of Langerhans. The flavonoid (1 mM) was found to increase insulin secretion from isolated rat islets of Langerhans in the presence of either 2 or 20 mM glucose, in static ...
Charles S.T. Hii, Simon L Howell
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Microtubule interactions in islets of Langerhans.
Hormone and metabolic research. Supplement series, 1980Morphologic and functional studies have implicated islet microtubules in the transport of the B-cell secretory product form the endoplasmic reticulum to the peripheral pool of secretory vesicles. The participation of the microtubular apparatus in the insulin release mechanism appears to be mediated through an increased rate of tubulin synthesis and of ...
Pipeleers, D G +3 more
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