HematologyObjectives: HLA Class I, HPA (Human platelet antigen), CD36 allo/isoantibodies, and platelet glycoprotein autoantibodies are the primary causes of immune-mediated platelet transfusion refractoriness (iPTR).
Bing Zhang +7 more
doaj +2 more sources
A Case of Neonatal Neutropenia Due to Anti-Fc Gamma Receptor IIIb Isoantibodies Treated with Recombinant Human Granulocyte Colony Stimulating Factor [PDF]
Case Reports in Medicine, 2009 Alloimmunization to granulocyte-specific antigens can occur during pregnancy. Maternal antibodies of IgG class can cross the placenta to result in alloimmune neonatal neutropenia.
Maja Tomicic +4 more
doaj +2 more sources
Modulation of tumor growth by crossreacting isoantibodies
Biomedicine & Pharmacotherapy, 2002 Tumor cells transfected with strong antigenic epitopes were able to stimulate humoral response against relevant wild-type tumors. Crossreacting immune sera have been obtained by immunizing C57BL/6 mice with OVA-transfected leukemia EL-4 (subclone E.G7) and OVA-transfected melanoma B16 (subclone MO.5) stimulated with interferon-gamma.
P Nguyen, Van Binh +2 more
openaire +3 more sources
Cytotoxic Isoantibodies and Immunologic Enhancement in Mice.
Experimental Biology and Medicine, 1966 Summary1. Cytotoxic isoantibodies and hemagglutinins are stimulated in response to H-2 isoantigenic differences between graft and host in mice. 2. This study offers data correlating cytotoxic isoantibody and immunological enhancement. 3. The mechanism of immunological enhancement has been shown to be associated with peripheral as well as central ...
Cruse, J M
core +4 more sources
In vitro characterization of rare anti-αIIbβ3 isoantibodies produced by patients with Glanzmann thrombasthenia that severely block fibrinogen binding and generate procoagulant platelets via complement activation. [PDF]
Res Pract Thromb HaemostGlanzmann thrombasthenia (GT) is a rare bleeding disorder caused by inherited defects of the platelet αβ integrin. Platelet transfusions can be followed by an immune response that can block integrin function by interfering with fibrinogen binding.
Lee CSM +7 more
europepmc +2 more sources
The Role of Anti-CD36 Antibodies in Immune Mediated Thrombocytopenia [PDF]
, 2022 Platelet reactive antibodies against polymorphic structures residing on platelet glycoproteins are a common cause of immune-mediated thrombocytopenias such as platelet transfusion refractoriness (PTR), post-transfusion purpura (PTP), or foetal and ...
Xu, Xiuzhang
core +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Interpreting antibody identification tests with large language models: Critical role of tabular data formatting. [PDF]
TransfusionAbstract Background Antibody identification testing is essential for preventing hemolytic transfusion reactions from unexpected red cell antibodies. Although automated interpretation is desirable to improve efficiency and consistency, conventional algorithmic approaches show limited accuracy, particularly in complex cases.
Lee J, Chung Y, Ko DH, Song EY, Kim H.
europepmc +2 more sources
Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
, 2021 Introduction: neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case report: we report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins.
Rodríguez-Sevilla, Juan José +11 more
core +1 more source
, 2022 Immunization against the platelet αIIbβ3 glycoprotein due to blood transfusion represents one of the most severe complications in Glanzmann thrombasthenia (GT) disease.
Yoann Huguenin +7 more
core +1 more source