Results 21 to 30 of about 2,274 (133)

Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies

Transfusion, EarlyView.
Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson   +33 more
wiley   +1 more source

Clinical application of a modified platelet desialylation test for mechanistic characterization of platelet transfusion refractoriness

Transfusion, EarlyView.
Abstract Background Platelet transfusion refractoriness (PTR) is a major challenge in transfusion medicine and may result from both immune and non‐immune mechanisms. Although alloantibodies are well‐established contributors, Fc‐independent pathways such as platelet desialylation have emerged as alternative mechanisms of clearance.
Karen Ziza, Thamy Silva, Mateus Domentino, Marina Conrado, João Oliveira, Elyse Moritz, Akemi Chiba, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Langhi Dante, Carla Dinardo   +11 more
wiley   +1 more source

AABB survey on directed blood donation practices

Transfusion, EarlyView.
Abstract Background Standardized guidance regarding the processes for collecting directed blood donations (DBD) is lacking, leading to variable practices. This study assessed laboratory, clinical, and charging practices for DBD collection in the United States and Canada. Study Design and Methods An electronic survey was distributed to United States and
Nabiha H. Saifee, Emily Coberly, Brian D. Adkins, Louise Helander, Nancy Robitaille, Laura K. Dilly, Lani Lieberman   +6 more
wiley   +1 more source

Comparison of four different in vitro assays for prediction of potential RBC antibody clinical significance

Transfusion, EarlyView.
Abstract Background The monocyte monolayer assay (MMA) uses monocytes, but it is known that antibody‐mediated hemolysis occurs in macrophages. Whether the use of macrophages would improve the predictive capacity of the MMA is unclear. Also, it is unclear if RBC alloantibodies contribute to hemolysis via antibody‐dependent cellular cytotoxicity (ADCC ...
Yeniley Ruiz Noa, Clémence Salou, Myriam Beshai, Selena Y. Cen, Lindsay K. Hillis, Katrina Billingsley, Donald R. Branch   +6 more
wiley   +1 more source

IrregulAB: An open‐source rule‐based engine for automated red cell antibody panel interpretation

Transfusion, EarlyView.
Abstract Background Interpretation of antibody identification panels remains a manual, expertise‐intensive step in transfusion testing; interpretive errors and long turnaround times persist even in well‐equipped hospitals. Existing commercial software is closed source and often omits enzyme‐phase, cold‐phase, and dosage‐sensitive exclusion rules ...
Davide Crucitti, Violeta Vidal Ballester, Jesús Gómez Fernández, Eugenia Fernandez Mellid, Angie Lizeth Ruge Perdomo, Carlos Pérez Míguez, Adrián Mosquera Orgueira   +6 more
wiley   +1 more source

A global survey of blood transfusion practices for patients with sickle cell disease

Transfusion, EarlyView.
Abstract Background Sickle cell disease (SCD) affects over 7 million people globally, with blood transfusion remaining a cornerstone of management. However, contemporary transfusion practices across diverse settings remain poorly characterized. We evaluated global transfusion practices for patients with SCD to identify gaps and inform resource ...
Jeremy W. Jacobs, Arwa Z. Al‐Riyami, Jeannie Callum, Meghan Delaney, David Daniel, Jenny White, Christopher Bocquet, Mohammed Farouk, Claude Tayou, Chinelo P. Onyenekwu, Kristina Prus, Divjot Singh Lamba, Julie Makani, Quentin Eichbaum, Luiz Amorim, Silvano Wendel, France Pirenne, Vernon Louw, Evan M. Bloch   +18 more
wiley   +1 more source

Glomerular plasmalemma vesicle‐associated protein‐1 as an endothelial remodelling marker complementing C4d in chronic active antibody‐mediated rejection

Histopathology, Volume 89, Issue 2, Page 372-382, August 2026.
Glomerular plasmalemma vesicle‐associated protein‐1 (PV‐1/PLVAP) identifies dynamic endothelial remodelling in chronic active antibody‐mediated rejection (caABMR), complementing glomerular C4d, which reflects a static footprint of complement activation. Combined assessment of PV‐1 and C4d captures complementary dimensions of microvascular pathology and
Yuto Igarashi, Mayu Shimokawa, Kunio Kawanishi, Toshihito Hirai, Hiroshi Seino, Tomokazu Shimizu, Hideki Ishida, Toshio Takagi   +7 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Statement: Evaluation and management of cell‐free DNA screening for fetal red cell antigen genotype in alloimmunized and non‐alloimmunized pregnancies

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract A substantial portion of RhD‐negative pregnant patients carry an RhD‐negative fetus and are not at risk of RhD alloimmunization. Knowing the fetal RhD genotype allows such patients to avoid unnecessary monitoring or treatment. The use of cell‐free DNA (cfDNA) to detect the fetal RhD genotype from maternal blood has been proposed to identify ...
Society for Maternal‐Fetal Medicine (SMFM), Britton D. Rink, Jeffrey A. Kuller, Teresa N. Sparks, Malavika Prabhu, Anne H. Mardy, Lorraine Dugoff, Joseph R. Biggio, SMFM Publications Committee   +8 more
wiley   +1 more source

Systemic barriers to recruitment of blood donors from African, Caribbean, and Black communities

HemaSphere, Volume 10, Issue 7, July 2026.
Edeghonghon Olayemi
wiley   +1 more source

Case Report: Dual impact of daratumumab in early T-cell precursor acute lymphoblastic leukemia -- consolidation therapy achieves remission and eliminates donor-specific HLA antibodies. [PDF]

Front Immunol
Wong KL, Tuy T, Quek J, Linn YC.
europepmc   +1 more source