Results 31 to 40 of about 2,576 (183)
Prenatal Diagnosis, EarlyView.ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup +4 more
wiley +1 more source
The Diagnosis and Prenatal Management of Non‐RHD Alloimmunizations
Prenatal Diagnosis, EarlyView.ABSTRACT Red blood cell (RBC) alloimmunization remains a relevant cause of hemolytic disease of the fetus and newborn (HDFN). Although RhD immunization has significantly decreased since the implementation of systematic prophylaxis, it is still the main cause of alloimmunization in pregnancy.
Mar Bennasar, Antoni Borrell
wiley +1 more source
From haemostasis to immunity: The expanding frontiers of platelet biology
British Journal of Haematology, EarlyView.Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley +1 more source
British Journal of Haematology, EarlyView.A comparison between bead‐based and cell‐based assays for autoantibody detection in childhood neutropenia revealed substantial discordance between platforms. Bead‐based methods should be complemented with cell‐based methods for optimal diagnostic sensitivity. Incorporating pro‐LL‐37 and ANC measurements into the clinical workup of childhood neutropenia
Paul Ratcliffe +3 more
wiley +1 more source
Italian Patients Journey for Gene Therapy in Haemophilia A
Haemophilia, EarlyView.ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno +19 more
wiley +1 more source
Evaluation of point‐of‐care versus laboratory antiglobulin‐enhanced major crossmatch testing in cats
Journal of Small Animal Practice, EarlyView.Objectives It is recommended that all cats, regardless of transfusion history, undergo major crossmatch prior to blood product administration to decrease the likelihood of immunological transfusion reactions. A reliable and user‐friendly point‐of‐care crossmatch test would help make crossmatch testing more accessible.
S. L. Blois +3 more
wiley +1 more source
Transfusion Medicine, EarlyView.Abstract Objective This study aimed to analyse the distribution and demand patterns of antigen‐negative red blood cells (RBCs) in Shandong Province, China (2022–2024), with a focus on ABO blood groups and clinically significant antigens. The research was designed to provide rigorous data for advancing precision transfusion protocols and to establish a ...
Aiping Zhao +7 more
wiley +1 more source
Transfusion Medicine, EarlyView.Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza +14 more
wiley +1 more source
Simple image analysis for reliability control of column agglutination test in pretransfusion testing
Transfusion Medicine, EarlyView.Abstract Objectives A novel meniscus‐based analysis provides a rapid method to identify analytical errors related to unrecognised pipetting errors. Background The indirect antihuman globulin test (IAT) is part of pretransfusion testing, enabling detection of erythrocyte alloantibodies.
Martin Töffner Pedersen +5 more
wiley +1 more source
Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies
Transfusion, EarlyView.Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike +33 more
wiley +1 more source